scholarly journals MRI Abnormalities Predominate in the Bottom Part of the Sulcus with Type II Focal Cortical Dysplasia: A Quantitative Study

2018 ◽  
Vol 40 (1) ◽  
pp. 184-190 ◽  
Author(s):  
Z. Liu ◽  
W. Hu ◽  
Z. Sun ◽  
X. Wang ◽  
L. Liu ◽  
...  
Keyword(s):  
Quantitative Study ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Type Ii ◽  
Bottom Part

scholarly journals A quantitative study of white matter hypomyelination and oligodendroglial maturation in focal cortical dysplasia type II

Epilepsia ◽  
2013 ◽  
Vol 54 (5) ◽  
pp. 898-908 ◽  
Author(s):  
Caterina Shepherd ◽  
Joan Liu ◽  
Joanna Goc ◽  
Lillian Martinian ◽  
Thomas S. Jacques ◽  
...  
Keyword(s):  
White Matter ◽  
Quantitative Study ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Type Ii

scholarly journals Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Arpna Srivastava ◽  
Krishan Kumar ◽  
Jyotirmoy Banerjee ◽  
Manjari Tripathi ◽  
Vivek Dubey ◽  
...  
Keyword(s):  
Rna Sequencing ◽  
Focal Cortical Dysplasia ◽  
Phospholipid Metabolism ◽  
Cortical Dysplasia ◽  
Type Ii ◽  
Tissue Samples ◽  
Significant Enrichment ◽  
Gene Expression Studies ◽  
Oligodendrocyte Development ◽  
High Throughput Gene Expression

AbstractFocal cortical dysplasia (FCD) is a malformation of the cerebral cortex with poorly-defined epileptogenic zones (EZs), and poor surgical outcome in FCD is associated with inaccurate localization of the EZ. Hence, identifying novel epileptogenic markers to aid in the localization of EZ in patients with FCD is very much needed. High-throughput gene expression studies of FCD samples have the potential to uncover molecular changes underlying the epileptogenic process and identify novel markers for delineating the EZ. For this purpose, we, for the first time performed RNA sequencing of surgically resected paired tissue samples obtained from electrocorticographically graded high (MAX) and low spiking (MIN) regions of FCD type II patients and autopsy controls. We identified significant changes in the MAX samples of the FCD type II patients when compared to non-epileptic controls, but not in the case of MIN samples. We found significant enrichment for myelination, oligodendrocyte development and differentiation, neuronal and axon ensheathment, phospholipid metabolism, cell adhesion and cytoskeleton, semaphorins, and ion channels in the MAX region. Through the integration of both MAX vs non-epileptic control and MAX vs MIN RNA sequencing (RNA Seq) data, PLP1, PLLP, UGT8, KLK6, SOX10, MOG, MAG, MOBP, ANLN, ERMN, SPP1, CLDN11, TNC, GPR37, SLC12A2, ABCA2, ABCA8, ASPA, P2RX7, CERS2, MAP4K4, TF, CTGF, Semaphorins, Opalin, FGFs, CALB2, and TNC were identified as potential key regulators of multiple pathways related to FCD type II pathology. We have identified novel epileptogenic marker elements that may contribute to epileptogenicity in patients with FCD and could be possible markers for the localization of EZ.

scholarly journals Genome-wide DNA Methylation and RNAseq Analyses Identify Aberrant Signalling Pathways in Focal Cortical Dysplasia (FCD) Type II

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Aparna Banerjee Dixit ◽  
Devina Sharma ◽  
Manjari Tripathi ◽  
Arpna Srivastava ◽  
Debasmita Paul ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Signalling Pathways ◽  
Type Ii ◽  
Genome Wide

Scalp High Frequency Oscillations Associated with Rhythmic Spikes Activity in Focal Cortical Dysplasia Type II

2016 ◽  
Vol 33 (3) ◽  
pp. 672-682
Author(s):  
Azusa Tabata ◽  
Keiko Hara ◽  
Motoki Inaji ◽  
Natsumi Tamada ◽  
Reina Kawanami ◽  
...  
Keyword(s):  
High Frequency ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Type Ii ◽  
High Frequency Oscillations

scholarly journals Superior Frontal Sulcus Focal Cortical Dysplasia Type II: An MRI, PET, and Quantified SEEG Study

2019 ◽  
Vol 10 ◽  
Author(s):  
Chao Zhang ◽  
Bao-tian Zhao ◽  
Aileen McGonigal ◽  
Wen-han Hu ◽  
Xiu Wang ◽  
...  
Keyword(s):  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Type Ii ◽  
Superior Frontal Sulcus

Somatic variants in new candidate genes identified in focal cortical dysplasia type II

Epilepsia ◽  
2020 ◽  
Vol 61 (4) ◽  
pp. 667-678
Author(s):  
Zhongbin Zhang ◽  
Kai Gao ◽  
Qingzhu Liu ◽  
Jiapeng Zhou ◽  
Xiyuan Li ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Type Ii

scholarly journals Type II focal cortical dysplasia: Electroclinical phenotype and surgical outcome related to imaging

Epilepsia ◽  
2012 ◽  
Vol 53 (2) ◽  
pp. 349-358 ◽  
Author(s):  
Francine Chassoux ◽  
Elisabeth Landré ◽  
Charles Mellerio ◽  
Baris Turak ◽  
Michael W. Mann ◽  
...  
Keyword(s):  
Surgical Outcome ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Type Ii
Sign in / Sign up

Export Citation Format

Share Document