scholarly journals Impact of Focal White Matter Damage on Localized Subcortical Gray Matter Atrophy in Multiple Sclerosis: A 5-Year Study

2018 ◽  
Author(s):  
T.A. Fuchs ◽  
K. Carolus ◽  
R.H.B. Benedict ◽  
N. Bergsland ◽  
D. Ramasamy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
White Matter Damage ◽  
Gray Matter Atrophy

Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study

2008 ◽  
Vol 15 (2) ◽  
pp. 204-211 ◽  
Author(s):  
G Tedeschi ◽  
D Dinacci ◽  
M Comerci ◽  
L Lavorgna ◽  
G Savettieri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Disease Progression ◽  
Gray Matter ◽  
Brain Atrophy ◽  
Disease Duration ◽  
Lesion Load ◽  
Whole Brain ◽  
Gray Matter Atrophy

Background To investigate in a large cohort of patients with multiple sclerosis (MS), lesion load and atrophy evolution, and the relationship between clinical and magnetic resonance imaging (MRI) correlates of disease progression. Methods Two hundred and sixty-seven patients with MS were studied at baseline and two years later using the same MRI protocol. Abnormal white matter fraction, normal appearing white matter fraction, global white matter fraction, gray matter fraction and whole brain fraction, T2-hyperintense, and T1-hypointense lesions were measured at both time points. Results The majority of patients were clinically stable, whereas MRI-derived brain tissue fractions were significantly different after 2 years. The correlation between MRI data at baseline and their variation during the follow-up showed that lower basal gray matter atrophy was significantly related with higher progression of gray matter atrophy during follow-up. The correlation between MRI parameters and disease duration showed that gray matter atrophy rate decreased with increasing disease duration, whereas the rate of white matter atrophy had a constant pattern. Lower basal gray matter atrophy was associated with increased probability of developing gray matter atrophy at follow-up, whereas gray matter atrophy progression over 2 years and new T2 lesion load were risk factors for whole brain atrophy progression. Conclusions In MS, brain atrophy occurs even after a relatively short period of time and in patients with limited progression of disability. Short-term brain atrophy progression rates differ across tissue compartments, as gray matter atrophy results more pronounced than white matter atrophy and appears to be a early phenomenon in the MS-related disease progression.

T1- and T2-Based MRI Measures of Diffuse Gray Matter and White Matter Damage in Patients with Multiple Sclerosis

2007 ◽  
Vol 17 ◽  
pp. 16S-21S ◽  
Author(s):  
Mohit Neema ◽  
James Stankiewicz ◽  
Ashish Arora ◽  
Venkata S.R. Dandamudi ◽  
Courtney E. Batt ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
White Matter Damage ◽  
T1 And T2

scholarly journals Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact

2016 ◽  
Vol 74 (3) ◽  
pp. 235-243 ◽  
Author(s):  
Juan Ignacio Rojas ◽  
Liliana Patrucco ◽  
Jimena Miguez ◽  
Edgardo Cristiano
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
Inflammatory Disease ◽  
Brain Atrophy ◽  
Clinical Impact ◽  
Cognitive Disability ◽  
Permanent Damage ◽  
Gray Matter Atrophy

ABSTRACT Multiple sclerosis (MS) was always considered as a white matter inflammatory disease. Today, there is an important body of evidence that supports the hypothesis that gray matter involvement and the neurodegenerative mechanism are at least partially independent from inflammation. Gray matter atrophy develops faster than white matter atrophy, and predominates in the initial stages of the disease. The neurodegenerative mechanism creates permanent damage and correlates with physical and cognitive disability. In this review we describe the current available evidence regarding brain atrophy and its consequence in MS patients.

scholarly journals Correlation between white matter damage and gray matter lesions in multiple sclerosis patients

2017 ◽  
Vol 12 (5) ◽  
pp. 787 ◽  
Author(s):  
Xia Cao ◽  
Xue-mei Han ◽  
Hong-ji Tian ◽  
Zheng Han ◽  
Ce Zhang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
White Matter Damage ◽  
Multiple Sclerosis Patients

scholarly journals Unraveling the relationship between regional gray matter atrophy and pathology in connected white matter tracts in long-standing multiple sclerosis

2015 ◽  
Vol 36 (5) ◽  
pp. 1796-1807 ◽  
Author(s):  
Martijn D. Steenwijk ◽  
Marita Daams ◽  
Petra J.W. Pouwels ◽  
Lisanne J. Balk ◽  
Prejaas K. Tewarie ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
White Matter Tracts ◽  
Gray Matter Atrophy ◽  
The Relationship

White Matter Damage in Alzheimer Disease and Its Relationship to Gray Matter Atrophy

Radiology ◽  
2011 ◽  
Vol 258 (3) ◽  
pp. 853-863 ◽  
Author(s):  
Federica Agosta ◽  
Michela Pievani ◽  
Stefania Sala ◽  
Cristina Geroldi ◽  
Samantha Galluzzi ◽  
...  
Keyword(s):  
White Matter ◽  
Alzheimer Disease ◽  
Gray Matter ◽  
White Matter Damage ◽  
Gray Matter Atrophy
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