scholarly journals Effects of MRI Protocol Parameters, Preload Injection Dose, Fractionation Strategies, and Leakage Correction Algorithms on the Fidelity of Dynamic-Susceptibility Contrast MRI Estimates of Relative Cerebral Blood Volume in Gliomas

2016 ◽  
Vol 38 (3) ◽  
pp. 478-484 ◽  
Author(s):  
K. Leu ◽  
J.L. Boxerman ◽  
B.M. Ellingson
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Dose Fractionation ◽  
Dynamic Susceptibility ◽  
Dynamic Susceptibility Contrast ◽  
Relative Cerebral Blood Volume ◽  
Dynamic Susceptibility Contrast Mri ◽  
Injection Dose ◽  
Mri Protocol ◽  
Susceptibility Contrast

scholarly journals Integrative Analysis of mRNA, microRNA, and Protein Correlates of Relative Cerebral Blood Volume Values in GBM Reveals the Role for Modulators of Angiogenesis and Tumor Proliferation

2016 ◽  
Vol 15 ◽  
pp. CIN.S33014 ◽  
Author(s):  
Arvind Rao ◽  
Ganiraju Manyam ◽  
Ganesh Rao ◽  
Rajan Jain
Keyword(s):  
Blood Volume ◽  
Messenger Rna ◽  
Cerebral Blood Volume ◽  
The Cancer Genome Atlas ◽  
Dynamic Susceptibility ◽  
Tumor Proliferation ◽  
Dynamic Susceptibility Contrast ◽  
Relative Cerebral Blood Volume ◽  
Hemodynamic Assessment ◽  
Susceptibility Contrast

Dynamic susceptibility contrast-enhanced magnetic resonance imaging is routinely used to provide hemodynamic assessment of brain tumors as a diagnostic as well as a prognostic tool. Recently, it was shown that the relative cerebral blood volume (rCBV), obtained from the contrast-enhancing as well as -nonenhancing portion of glioblastoma (GBM), is strongly associated with overall survival. In this study, we aim to characterize the genomic correlates (microRNA, messenger RNA, and protein) of this vascular parameter. This study aims to provide a comprehensive radiogenomic and radioproteomic characterization of the hemodynamic phenotype of GBM using publicly available imaging and genomic data from the Cancer Genome Atlas GBM cohort. Based on this analysis, we identified pathways associated with angiogenesis and tumor proliferation underlying this hemodynamic parameter in GBM.

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