scholarly journals Quantitative Susceptibility Mapping and R2* Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation

2016 ◽  
Vol 37 (9) ◽  
pp. 1629-1635 ◽  
Author(s):  
Y. Zhang ◽  
S.A. Gauthier ◽  
A. Gupta ◽  
W. Chen ◽  
J. Comunale ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
White Matter Lesion ◽  
Susceptibility Mapping ◽  
Iron Accumulation ◽  
Quantitative Susceptibility Mapping ◽  
Lesion Development ◽  
Myelin Breakdown ◽  
Myelin Debris

scholarly journals Quantitative susceptibility mapping (QSM) of white matter multiple sclerosis lesions: Interpreting positive susceptibility and the presence of iron

2014 ◽  
Vol 74 (2) ◽  
pp. 564-570 ◽  
Author(s):  
Cynthia Wisnieff ◽  
Sriram Ramanan ◽  
John Olesik ◽  
Susan Gauthier ◽  
Yi Wang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping

scholarly journals Thalamic white matter in multiple sclerosis: A combined diffusion-tensor imaging and quantitative susceptibility mapping study

2018 ◽  
Vol 39 (10) ◽  
pp. 4007-4017 ◽  
Author(s):  
Niels Bergsland ◽  
Ferdinand Schweser ◽  
Michael G. Dwyer ◽  
Bianca Weinstock-Guttman ◽  
Ralph H. B. Benedict ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Susceptibility Mapping ◽  
Mapping Study ◽  
Quantitative Susceptibility Mapping

White matter lesion characteristics on MRI can differentiate multiple sclerosis from patent foramen ovale

2021 ◽  
Vol 429 ◽  
pp. 118301
Author(s):  
Gianmarco Severa ◽  
Rosa Cortese ◽  
Antonio Covelli ◽  
Marco Battaglini ◽  
Jian Zhang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Patent Foramen Ovale ◽  
White Matter Lesion ◽  
Foramen Ovale

Microstructural fronto-striatal and temporo-insular alterations are associated with fatigue in patients with multiple sclerosis independent of white matter lesion load and depression

2019 ◽  
Vol 26 (13) ◽  
pp. 1708-1718 ◽  
Author(s):  
Miklos Palotai ◽  
Michele Cavallari ◽  
Ismail Koubiyr ◽  
Alfredo Morales Pinzon ◽  
Aria Nazeri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Physical Disability ◽  
Disease Duration ◽  
White Matter Lesion ◽  
Brain Magnetic Resonance Imaging ◽  
Brain Regions ◽  
Specific Substrate ◽  
Patient Stratification ◽  
Lesion Load

Background: Fatigue in multiple sclerosis (MS) has been inconsistently associated with disruption of specific brain circuitries. Temporal fluctuations of fatigue have not been considered. Objective: The aim of this study was to investigate the association of fatigue with brain diffusion abnormalities, using robust criteria for patient stratification based on longitudinal patterns of fatigue. Methods: Patient stratification: (1) sustained fatigue (SF, n = 26): latest two Modified Fatigue Impact Scale (MFIS) ⩾ 38; (2) reversible fatigue (RF, n = 25): latest MFIS < 38 and minimum one previous MFIS ⩾ 38; and (3) never fatigued (NF, n = 42): MFIS always < 38 (five assessments minimum). 3T brain magnetic resonance imaging (MRI) was used to perform voxel-wise comparison of fractional anisotropy (FA) between the groups controlling for age, sex, disease duration, physical disability, white matter lesion load (T2LV), and depression. Results: SF and, to a lesser extent, RF patients showed lower FA in multiple brain regions compared to NF patients, independent of age, sex, disease duration, and physical disability. In cingulo-postcommissural-striato-thalamic regions, the differences in FA between SF and NF (but not between RF and NF or SF) patients were independent of T2LV, and in ventromedial prefronto-precommissuro-striatal and temporo-insular areas, independent of T2LV and depression. Conclusion: Damage to ventromedial prefronto-precommissuro-striatal and temporo-insular pathways appears to be a specific substrate of SF in MS.

Quantitative susceptibility mapping as a biomarker for evaluating white matter alterations in Parkinson’s disease

2018 ◽  
Vol 13 (1) ◽  
pp. 220-231 ◽  
Author(s):  
Xiaojun Guan ◽  
Peiyu Huang ◽  
Qiaoling Zeng ◽  
Chunlei Liu ◽  
Hongjiang Wei ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping
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