scholarly journals Associations between Cerebral Embolism and Carotid Intraplaque Hemorrhage during Protected Carotid Artery Stenting

2015 ◽  
Vol 37 (4) ◽  
pp. 686-691 ◽  
Author(s):  
G.H. Chung ◽  
J.Y. Jeong ◽  
H.S. Kwak ◽  
S.B. Hwang
2020 ◽  
Vol 137 ◽  
pp. e298-e307 ◽  
Author(s):  
Gefei Zhao ◽  
Xiao Tang ◽  
Hanfei Tang ◽  
Jiang Lin ◽  
Wei Sun ◽  
...  

2021 ◽  
Vol 17 (7) ◽  
pp. 599-606
Author(s):  
Ichiro Nakagawa ◽  
Masashi Kotsugi ◽  
Hun Soo Park ◽  
Takanori Furuta ◽  
Fumiya Sato ◽  
...  

Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Kota Maekawa ◽  
Masunari Shibata ◽  
Hidetaka Nakajima ◽  
Yotaro Kitano ◽  
Masaru Seguchi ◽  
...  

2018 ◽  
Vol 46 (5-6) ◽  
pp. 242-248 ◽  
Author(s):  
Kota Maekawa ◽  
Masunari Shibata ◽  
Hideki Nakajima ◽  
Yotaro Kitano ◽  
Masaru Seguchi ◽  
...  

Object: We investigated possible associations among the presence of cholesterol crystals in embolic debris, the proportions of debris components, and postoperative cerebral embolism in patients undergoing carotid artery stenting (CAS). Methods: Sixty-seven consecutive procedures were performed for internal carotid artery stenosis with CAS at our hospital between November 2015 and February 2018. Procedures for emergency CAS for stroke in evolution or crescendo transient ischemic attack were excluded (n = 12). The embolic debris from remaining procedures (n = 55) was stained with hematoxylin-eosin and the red blood cells, white blood cells, and fibrin were quantified by color-based segmentation. Cholesterol crystals and calcification were examined histopathologically. Diffusion-weighted imaging (DWI) was performed 1–3 days after CAS, and the images were used to classify procedures according to the presence of new lesions. Results: Of the 55 CAS procedures, new DWI lesions were identified after 32. One patient had symptomatic cerebral embolism. Higher proportions of patients with cholesterol crystals in embolic debris (17 vs. 78%, p < 0.001) and higher proportion of white blood cells (mean 2.3 [0–9.9] vs. 4.2% [0–29.9%], p < 0.01) were observed in the embolic debris of procedures with and without new DWI lesions. Conclusions: Cholesterol crystals were common in the embolic debris from patients with postoperative ischemic lesions after CAS. These results suggest that inflammatory destabilization of the intraplaque lipid component is related to postprocedural DWI lesions.


2011 ◽  
Vol 32 (2) ◽  
pp. 164-170 ◽  
Author(s):  
Michael Rosenkranz ◽  
Arkadiusz Russjan ◽  
Einar Goebell ◽  
Stefanie Havemeister ◽  
Götz Thomalla ◽  
...  

2009 ◽  
Vol 27 (5) ◽  
pp. 443-449 ◽  
Author(s):  
Michael Rosenkranz ◽  
Oliver Wittkugel ◽  
Christian Waiblinger ◽  
Götz Thomalla ◽  
Anna Krützelmann ◽  
...  

2021 ◽  
pp. 1-6
Author(s):  
Keisuke Tokunaga ◽  
So Tokunaga ◽  
Kenta Hara ◽  
Masahiro Yasaka ◽  
Yasushi Okada ◽  
...  

OBJECTIVE To test the hypothesis that intraplaque hemorrhage is a predictor of restenosis after carotid artery stenting (CAS), the association between intraplaque high-intensity signal (HIS) on time-of-flight MR angiography (TOF-MRA), as a marker of intraplaque hemorrhage, and restenosis after CAS was assessed in the present observational study. METHODS Consecutive patients who underwent initial CAS for atherosclerotic stenosis in the cervical internal carotid artery in the authors’ department were enrolled. Of these, patients without preprocedural cervical TOF-MRA were excluded. Outcome measures were ≥ 50% restenosis, defined as a peak systolic velocity of > 1.3 m/sec; or occlusion and ≥ 70% restenosis, defined as a peak systolic velocity of > 2.1 m/sec; or occlusion on carotid duplex ultrasound. RESULTS Of 230 consecutive patients who underwent initial CAS, 22 without preprocedural cervical TOF-MRA were excluded. Of the remaining 208 patients (mean age 73 years; 33 women), 46 had intraplaque HIS. Ultrasound follow-up was not performed in 4 patients. The median follow-up duration was 3.2 years (interquartile range 1.7–5.1 years). During the follow-up period, 102 patients had ≥ 50% restenosis and 36 had ≥ 70% restenosis. Intraplaque HIS was significantly associated with increased risk of ≥ 50% restenosis (adjusted hazard ratio 2.18; 95% CI 1.28–3.68) and ≥ 70% restenosis (adjusted hazard ratio 3.12; 95% CI 1.32–7.52). CONCLUSIONS Intraplaque HIS on TOF-MRA was associated with increased risk of restenosis after CAS. The present results indicate that intraplaque hemorrhage is a predictor of restenosis after CAS.


2017 ◽  
Vol 26 (10) ◽  
pp. 2329-2335 ◽  
Author(s):  
Tomoaki Murakami ◽  
Hajime Nakamura ◽  
Takeo Nishida ◽  
Tomohiko Ozaki ◽  
Katsunori Asai ◽  
...  

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