scholarly journals Medial Occipital Lobe Hyperperfusion Identified by Arterial Spin-Labeling: A Poor Prognostic Sign in Patients with Hypoxic-Ischemic Encephalopathy

2015 ◽  
Vol 36 (12) ◽  
pp. 2292-2295 ◽  
Author(s):  
A. de Havenon ◽  
A. Sultan-Qurraie ◽  
D. Tirschwell ◽  
W. Cohen ◽  
J. Majersik ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Occipital Lobe ◽  
Spin Labeling ◽  
Hypoxic Ischemic Encephalopathy ◽  
Prognostic Sign ◽  
Ischemic Encephalopathy

scholarly journals Changes in brain perfusion in successive arterial spin labeling MRI scans in neonates with hypoxic-ischemic encephalopathy

2019 ◽  
Vol 24 ◽  
pp. 101939 ◽  
Author(s):  
Maïa Proisy ◽  
Isabelle Corouge ◽  
Antoine Legouhy ◽  
Amélie Nicolas ◽  
Valérie Charon ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Brain Perfusion ◽  
Spin Labeling ◽  
Hypoxic Ischemic Encephalopathy ◽  
Mri Scans ◽  
Ischemic Encephalopathy

The value of arterial spin labeling imaging in the classification and prognostic evaluation of neonatal hypoxic-ischemic encephalopathy

2021 ◽  
Vol 18 ◽  
Author(s):  
Jianing Wang ◽  
Jia Li ◽  
Xiaoping Yin ◽  
Huan Zhou ◽  
Yating Zheng ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Arterial Spin Labeling ◽  
Poor Prognosis ◽  
Spin Labeling ◽  
Good Prognosis ◽  
Hypoxic Ischemic Encephalopathy ◽  
Clinical Prognosis ◽  
Prognosis Group ◽  
Ischemic Encephalopathy ◽  
Clinical Grading

Objective: This study aims to investigate the correlation between cerebral blood flow (CBF) values and neonatal behavioral neurological assessment (NBNA) in hypoxic-ischemic encephalopathy (HIE), the relationship between early CBF value changes and the prognosis of neonatal HIE, and the consistency between the clinical grading and magnetic resonance (MR) grading of HIE. Methods: Forty neonates with HIE were scanned using the three-dimensional arterial spin labeling (ASL) sequencing of the cranial magnetic resonance imaging (MRI). These newborns were classified as having mild, moderate and severe HIE, according to the clinical grading, and as being normal or having mild, moderate, or severe HIE, according to the MRI grading. Then, the consistency of these two grading systems were compared. Afterwards, the differences in the CBF values of neonates in groups with mild, moderate and severe HIE were compared. In addition, these neonates were grouped according to their NBNA scores. A score of ≥35 was considered a good prognosis, while a score of ≤35 was considered a poor prognosis. The differences in CBF values between these two groups were compared, and the correlation between the CBF values and NBNA scores was determined. Results: There was a strong consistency between the evaluation results for the clinical grading and MR grading (kappa value = 0.672, P<0.001). The differences in CBF values for the basal ganglia (BG) area and thalamus, and the differences in NBNA scores for groups with mild, moderate, or severe HIE were statistically significant (P<0.05). The differences between the poor prognosis group and good prognosis group, in terms of the CBF values for the BG area and thalamus, and the NBNA scores, were statistically significant (P<0.05). The CBF values in the BG region and thalamus were closely and negatively correlated with the NBNA scores. Conclusion: Early CBF values in the BG area and thalamus can objectively and visually reflect the severity of the HIE, and be used to predict the outcome of functional brain damage, allowing early neuroprotective treatment to be initiated. The higher the perfusion in the BG region and thalamus, the lower the NBNA score, and the worse the prognosis would likely be. ASL combined with the NBNA score provides a more comprehensive classification for HIE and a more accurate assessment of the clinical prognosis, providing more medical imaging information for early clinical treatment.

scholarly journals Cerebaral Hyperperfusion in  General Paralysis Patients

2020 ◽  
Author(s):  
Yali Wu ◽  
jingjing li ◽  
wenqing wu
Keyword(s):  
Blood Flow ◽  
Healthy Subjects ◽  
Arterial Spin Labeling ◽  
Parietal Lobe ◽  
Three Dimensional ◽  
Occipital Lobe ◽  
Spin Labeling ◽  
General Paralysis ◽  
Limbic Lobe ◽  
Continuous Arterial Spin Labeling

Abstract Objective This study aimed to identify the cerebral blood flow (CBF) in patients with general paralysis (GP). Methods Three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) imaging was performed to measure the CBF in twenty patients with GP and twenty healthy subjects(NC). CBF was normalized to reduce variations among subjects. CBF was compared between the groups. Results Compared with the healthy subjects, the patients with GP exhibited increased CBF in the frontal lobe, temporal lobe, insular lobe, limbic lobe, and parietal lobe(all P<0.05). There was no difference in CBF of the occipital lobe between the GP group and the NC group(all P>0.05). Conclusions Our results suggest that the patients with GP may exhibit regional increased CBF, which may be one of the pathogenesis of general paralysis.

scholarly journals Reduction of BOLD interference in pseudo-continuous arterial spin labeling: towards quantitative fMRI

2017 ◽  
Vol 38 (5) ◽  
pp. 847-856 ◽  
Author(s):  
Geoffrey Warnock ◽  
Pinar S Özbay ◽  
Felix P Kuhn ◽  
Daniel Nanz ◽  
Alfred Buck ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Time Lag ◽  
Occipital Lobe ◽  
Spin Labeling ◽  
Blood Oxygenation ◽  
Background Suppression ◽  
Oxygenation Level ◽  
Neuronal Stimulation ◽  
Continuous Arterial Spin Labeling ◽  
Stimulation Paradigm

Fluctuations in blood-oxygenation level dependent (BOLD) signal and perfusion affect the quantification of changes in cerebral blood flow (CBF), coupled to neuronal activity, in arterial spin labeling (ASL). Subtraction methods for control and labeled MR images (i.e. pair-wise, surround subtraction, and subtraction of sinc-interpolated images), postulated to mitigate this interference in pseudo-continuous ASL (pCASL), were evaluated by comparison with quantitative 15O-water PET. At rest, a good agreement in the CBF values was found between PET and MRI for each of the subtraction methods. Stimulation of the visual system resulted in a regional CBF increase in the occipital lobe, which was detectable in both modalities. Bland–Altman analysis showed a systematic underestimation of the CBF values during activation in MRI. Evaluation of the relative CBF change induced by neuronal stimulation showed good inter-modality agreement for the three subtraction methods. Perfusion data obtained with each subtraction method followed the stimulation paradigm without significant differences in the correlation patterns or in the time lag between stimulation and perfusion response. Comparison to the gold standard confirmed the detectability of a neuronal stimulation pattern by pCASL. The results indicate that the combined use of background suppression and short TE reduces the BOLD-weighting in the pCASL signal.

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