scholarly journals Nigrosome 1 Detection at 3T MRI for the Diagnosis of Early-Stage Idiopathic Parkinson Disease: Assessment of Diagnostic Accuracy and Agreement on Imaging Asymmetry and Clinical Laterality

2015 ◽  
Vol 36 (11) ◽  
pp. 2010-2016 ◽  
Author(s):  
Y. Noh ◽  
Y.H. Sung ◽  
J. Lee ◽  
E.Y. Kim
Keyword(s):  
Diagnostic Accuracy ◽  
Parkinson Disease ◽  
Early Stage ◽  
Disease Assessment ◽  
3T Mri ◽  
Idiopathic Parkinson Disease

Patterns of striatal dopamine depletion in early Parkinson disease

Neurology ◽  
2020 ◽  
Vol 95 (3) ◽  
pp. e280-e290 ◽  
Author(s):  
Seok Jong Chung ◽  
Hye Sun Lee ◽  
Han Soo Yoo ◽  
Yang Hyun Lee ◽  
Phil Hyu Lee ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Parkinson Disease ◽  
Cox Regression ◽  
Early Stage ◽  
Freezing Of Gait ◽  
Striatal Dopamine ◽  
Dopamine Depletion ◽  
Wearing Off ◽  
Striatal Dopamine Depletion ◽  
Selective Dopamine

ObjectiveTo investigate whether the patterns of striatal dopamine depletion on dopamine transporter (DAT) scans could provide information on the long-term prognosis in Parkinson disease (PD).MethodsWe enrolled 205 drug-naive patients with early-stage PD, who underwent 18F-FP-CIT PET scans at initial assessment and received PD medications for 3 or more years. After quantifying the DAT availability in each striatal subregion, factor analysis was conducted to simplify the identification of striatal dopamine depletion patterns and to yield 4 striatal subregion factors. We assessed the effect of these factors on the development of levodopa-induced dyskinesia (LID), wearing-off, freezing of gait (FOG), and dementia during the follow-up period (6.84 ± 1.80 years).ResultsThe 4 factors indicated which striatal subregions were relatively preserved: factor 1 (caudate), factor 2 (more-affected sensorimotor striatum), factor 3 (less-affected sensorimotor striatum), and factor 4 (anterior putamen). Cox regression analyses using the composite scores of these striatal subregion factors as covariates demonstrated that selective dopamine depletion in the sensorimotor striatum was associated with a higher risk for developing LID. Selective dopamine loss in the putamen, particularly in the anterior putamen, was associated with early development of wearing-off. Selective involvement of the anterior putamen was associated with a higher risk for dementia conversion. However, the patterns of striatal dopamine depletion did not affect the risk of FOG.ConclusionsThese findings suggested that the patterns of striatal dopaminergic denervation, which were estimated by the equation derived from the factor analysis, have a prognostic implication in patients with early-stage PD.

scholarly journals Lifestyle, Family History, and Risk of Idiopathic Parkinson Disease: A Large Danish Case-Control Study

2015 ◽  
Vol 181 (10) ◽  
pp. 808-816 ◽  
Author(s):  
Line Kenborg ◽  
Christina F. Lassen ◽  
Beate Ritz ◽  
Klaus K. Andersen ◽  
Jane Christensen ◽  
...  
Keyword(s):  
Family History ◽  
Parkinson Disease ◽  
Case Control Study ◽  
Case Control ◽  
Idiopathic Parkinson Disease ◽  
Control Study

Plasma Metabolome Signature in Patients with Early-stage Parkinson Disease

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Elena E. Balashova ◽  
Petr G. Lokhov ◽  
Dmitry L. Maslov ◽  
Oxana P. Trifonova ◽  
Diana M. Khasanova ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Early Stage ◽  
Plasma Metabolome

Diagnostic Accuracy of Axillary Ultrasound in Early–Stage Breast Cancer

2018 ◽  
Vol 81 (5) ◽  
pp. 421-425
Author(s):  
Tugba Han Yilmaz ◽  
Hasan Yerli ◽  
Baha Arslan ◽  
Varlık Erol ◽  
Huseyin Gulay
Keyword(s):  
Breast Cancer ◽  
Diagnostic Accuracy ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
Axillary Ultrasound

scholarly journals The Diagnostic Role of Sputum miRNA in Non-Small Cell Lung Cancer

2020 ◽  
Author(s):  
Zaoxiu Hu ◽  
Yonghe Zhao ◽  
Yanlong Yang ◽  
Zhenghai Shen ◽  
Yunchao Huang
Keyword(s):  
Lung Cancer ◽  
Diagnostic Accuracy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Stage I ◽  
Small Cell Lung ◽  
Diagnostic Role

Abstract Objective: Recent studies indicated sputum miRNAs may provide a promising approach for non-small cell lung cancer (NSCLC) diagnosis. But some results were still inconsistent. So, we performed meta-analysis to evaluate the diagnostic role of sputum miRNAs for the detection of NSCLC.Methods: Eligible studies that estimated the diagnostic accuracy of sputum miRNAs in NSCLC were searched in Pubmed, Embase and Web of Science and Chinese National Knowledge Infrastructure (CNKI). Data from the eligible studies were collected and pooled; sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratios, weighted symmetric summary ROC curve and the area under the curve (AUC) were calculated by bi-variate random effects model. The between-study heterogeneity was evaluated by Q test and I2 statistics.Results: 30 studies from 16 articles were included for analysis. The overall analysis yielded the sensitivity of 0.77 (95% CI: 0.73–0.81) and specificity of 0.87 (95% CI: 0.83–0.90), with an area under the SROC curve (AUC) of 0.89 (95% CI: 0.86–0.91). Subgroup analysis revealed the diagnostic accuracy in multiple miRNAs studies was higher than single miRNA (the sensitivity, specifcity and an AUC of multiple miRNAs were 0.76, 0.88 and 0.90; and for single miRNA, it was 0.74, 0.74, and 0.80). The diagnostic performance in early stage NSCLC was also very high (the sensitivity, specifcity and an AUC of stage I/II was 0.76, 0.88 and 0.91; and for stage I, it was 0.79, 0.85, and 0.87). We also found miR-210, miR-21, miR-31 and miR-126-3p might serve as potential biomarkers for lung cancer.Conclusion: Sputum miRNAs was useful noninvasive biomarkers for NSCLC diagnosis.

Skin nerve  -synuclein deposits: A biomarker for idiopathic Parkinson disease

Neurology ◽  
2014 ◽  
Vol 82 (15) ◽  
pp. 1362-1369 ◽  
Author(s):  
V. Donadio ◽  
A. Incensi ◽  
V. Leta ◽  
M. P. Giannoccaro ◽  
C. Scaglione ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Idiopathic Parkinson Disease

Psychometric properties of the Berg balance scale in idiopathic Parkinson’ disease in the drug off-phase

2018 ◽  
Vol 39 (12) ◽  
pp. 2175-2181 ◽  
Author(s):  
Ghorban Taghizadeh ◽  
Pablo Martinez-Martin ◽  
Seyed-Mohammad Fereshtehnejad ◽  
Seyed Amirhasan Habibi ◽  
Negar Nikbakht ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Psychometric Properties ◽  
Berg Balance Scale ◽  
Balance Scale ◽  
Idiopathic Parkinson Disease

Voice Quality and Orofacial Strength as Outcome of Levodopa Effectiveness in Patients with Early Idiopathic Parkinson Disease: A Preliminary Report

2019 ◽  
Vol 33 (5) ◽  
pp. 716-720 ◽  
Author(s):  
Jérôme R. Lechien ◽  
Serge Blecic ◽  
Yves Ghosez ◽  
Kathy Huet ◽  
Bernard Harmegnies ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Preliminary Report ◽  
Voice Quality ◽  
Idiopathic Parkinson Disease
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