scholarly journals Glioma: Application of Histogram Analysis of Pharmacokinetic Parameters from T1-Weighted Dynamic Contrast-Enhanced MR Imaging to Tumor Grading

2014 ◽  
Vol 35 (6) ◽  
pp. 1103-1110 ◽  
Author(s):  
S. C. Jung ◽  
J. A. Yeom ◽  
J.- H. Kim ◽  
I. Ryoo ◽  
S. C. Kim ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Histogram Analysis ◽  
Pharmacokinetic Parameters ◽  
Tumor Grading ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

New intravascular contrast agent applied to dynamic contrast enhanced MR imaging of human breast cancer

2003 ◽  
Vol 44 (3) ◽  
pp. 275-283 ◽  
Author(s):  
J. Rydland ◽  
A. Bjørnerud ◽  
O. Haugen ◽  
G. Torheim ◽  
C. Torres ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Human Breast Cancer ◽  
Hot Spot ◽  
Human Breast ◽  
Tumor Grading ◽  
Dynamic Contrast Enhanced ◽  
Intravascular Contrast Agent ◽  
Contrast Enhanced ◽  
Dynamic Mr

Purpose: To evaluate the feasibility of using dynamic contrast-enhanced MR imaging with a new intravascular contrast agent in grading human breast cancer. Material and Methods: 23 patients with 27 breast tumors (21 carcinomas and 6 fibroadenomas) were examined with dynamic MR imaging after administration of Clariscan, an iron oxide nanoparticle with large T1 relaxivity and a long plasma half life. A 3D T1-weighted gradient echo sequence with an acquisition time of 60 s was repeated at regular intervals of 3–5 min before and up to 1 h after injection of 2 mg/kg b.w. of Clariscan. The endothelial transfer constant, Kps, which reflects overall vascular permeability, and the fractional plasma volume, fPV, were estimated from time-intensity curves acquired from three separate regions of interest (ROIs): whole tumor, a permeability hot spot, and a blood volume hot spot. Kps and fPV were compared to the results of histologic tumor grading (Scarff-Bloom-Richardson, SBR) and microvascular density, MVD. Results: A statistically significant correlation between the MR-derived Kps parameters and the SBR score was obtained for the whole tumor ROI ( R = 0.70), and for the permeability hot spot ROIs ( R = 0.67). A correlation between fPV and SBR was detected for the blood volume hot spot ROIs ( R = 0.48). There was no statistically significant correlation between Kps or fPV with MVD. Conclusion: The results support the hypothesis that dynamic MR with the intravascular contrast agent Clariscan may be used for non-invasive tumor grading.

Dynamic contrast-enhanced MR imaging pharmacokinetic parameters as predictors of treatment response of brain metastases in patients with lung cancer

2017 ◽  
Vol 27 (9) ◽  
pp. 3733-3743 ◽  
Author(s):  
Grégory Kuchcinski ◽  
Emilie Le Rhun ◽  
Alexis B. Cortot ◽  
Elodie Drumez ◽  
Romain Duhal ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mr Imaging ◽  
Brain Metastases ◽  
Treatment Response ◽  
Pharmacokinetic Parameters ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

Dynamic contrast – enhanced MR imaging of the stimulated pituitary gland

2004 ◽  
Vol 112 (S 1) ◽  
Author(s):  
C Maier ◽  
M Riedl ◽  
M Clodi ◽  
C Bieglmayer ◽  
V Mlynarik ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Pituitary Gland ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

Dynamic contrast-enhanced MR imaging of musculoskeletal tumors: Basic principles and clinical applications

1996 ◽  
Vol 6 (2) ◽  
pp. 311-321 ◽  
Author(s):  
Koenraad L. Verstraete ◽  
Henk-Jan Van der Woude ◽  
Pancras C. W. Hogendoorn ◽  
Yves De Deene ◽  
Marc Kunnen ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Clinical Applications ◽  
Basic Principles ◽  
Musculoskeletal Tumors ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced
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