scholarly journals Subcortical Deep Gray Matter Pathology in Patients with Multiple Sclerosis Is Associated with White Matter Lesion Burden and Atrophy but Not with Cortical Atrophy: A Diffusion Tensor MRI Study

2013 ◽  
Vol 35 (5) ◽  
pp. 912-919 ◽  
Author(s):  
R. Cappellani ◽  
N. Bergsland ◽  
B. Weinstock-Guttman ◽  
C. Kennedy ◽  
E. Carl ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
White Matter Lesion ◽  
Cortical Atrophy ◽  
Diffusion Tensor Mri ◽  
Deep Gray Matter ◽  
Mri Study

scholarly journals Thalamic Injury and Cognition in Multiple Sclerosis

2021 ◽  
Vol 11 ◽  
Author(s):  
Moein Amin ◽  
Daniel Ontaneda
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Clinical Manifestations ◽  
White Matter Injury ◽  
Volume Loss ◽  
Thalamic Nuclei ◽  
Dorsomedial Nucleus ◽  
Deep Gray Matter

Multiple sclerosis (MS) produces demyelination and degeneration in both gray and white matter. Both cortical and deep gray matter injury is observed during the course of MS. Among deep gray matter structures, the thalamus has received special attention, as it undergoes volume loss in different MS subtypes and is involved in the earliest form of the disease, radiologically isolated syndrome. The thalamus plays an important role as an information relay center, and involvement of the thalamus in MS has been associated with a variety of clinical manifestations in MS, including fatigue, movement disorders, pain, and cognitive impairment (CI). Similar to thalamic volume loss, CI is seen from the earliest stages of MS and is potentially one of the most debilitating manifestations of the disease. The thalamus, particularly the dorsomedial nucleus as part of the basolateral limbic circuit and anterior thalamic nuclei through connections with the prefrontal cortex, has been shown to be involved in CI. Specifically, several cognitive performance measures such as processing speed and memory correlate with thalamic volume. Thalamic atrophy is one of the most important predictors of CI in MS, and both thalamic volume, diffusion tensor imaging measures, and functional activation correlate with the degree of CI in MS. Although the exact mechanism of thalamic atrophy is not well-understood, it is hypothesized to be secondary to degeneration following white matter injury resulting in secondary neurodegeneration and neuronal loss. The thalamus may represent an ideal biomarker for studies aiming to test neuroprotective or restorative therapies aimed at cognition.

scholarly journals Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study

2018 ◽  
Vol 40 (1) ◽  
pp. 99-106 ◽  
Author(s):  
G. Pontillo ◽  
S. Cocozza ◽  
R. Lanzillo ◽  
C. Russo ◽  
M.D. Stasi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Atrophy ◽  
Multimodal Mri ◽  
Deep Gray Matter ◽  
Mri Study

Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study

Neurology ◽  
2001 ◽  
Vol 57 (12) ◽  
pp. 2307-2310 ◽  
Author(s):  
M. O'Sullivan ◽  
P. E. Summers ◽  
D. K. Jones ◽  
J. M. Jarosz ◽  
S. C.R. Williams ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Diffusion Tensor Mri ◽  
Normal Appearing White Matter ◽  
Mri Study

6. Diffusion tensor MRI study of the spinal cord in patients with multiple sclerosis

2011 ◽  
Vol 122 (4) ◽  
pp. e3
Author(s):  
J. von Meyenburg ◽  
B. Wilm ◽  
A. Weck ◽  
J. Petersen ◽  
E. Gallus ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Diffusion Tensor ◽  
Diffusion Tensor Mri ◽  
Mri Study

White matter structure and clinical characteristics of stroke patients: A diffusion tensor MRI study

2016 ◽  
Vol 1635 ◽  
pp. 61-70 ◽  
Author(s):  
Ryo Ueda ◽  
Naoki Yamada ◽  
Wataru Kakuda ◽  
Masahiro Abo ◽  
Atsushi Senoo
Keyword(s):  
White Matter ◽  
Clinical Characteristics ◽  
Diffusion Tensor ◽  
Diffusion Tensor Mri ◽  
Stroke Patients ◽  
Mri Study

Segmenting brain white matter, gray matter and cerebro-spinal fluid using diffusion tensor-MRI derived indices

2001 ◽  
Vol 19 (9) ◽  
pp. 1167-1172 ◽  
Author(s):  
Mara Cercignani ◽  
Matilde Inglese ◽  
Malgorzata Siger-Zajdel ◽  
Massimo Filippi
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Spinal Fluid ◽  
Diffusion Tensor Mri ◽  
Brain White Matter

scholarly journals Short-term evolution of spinal cord damage in multiple sclerosis: a diffusion tensor MRI study

2012 ◽  
Vol 54 (10) ◽  
pp. 1171-1178 ◽  
Author(s):  
M. Théaudin ◽  
G. Saliou ◽  
B. Ducot ◽  
K. Deiva ◽  
C. Denier ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Diffusion Tensor ◽  
Diffusion Tensor Mri ◽  
Short Term ◽  
Spinal Cord Damage ◽  
Term Evolution ◽  
Mri Study
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