scholarly journals Intraplaque High-Intensity Signal on 3D Time-of-Flight MR Angiography Is Strongly Associated with Symptomatic Carotid Artery Stenosis

2013 ◽  
Vol 35 (3) ◽  
pp. 557-561 ◽  
Author(s):  
A. Gupta ◽  
H. Baradaran ◽  
H. Kamel ◽  
A. Mangla ◽  
A. Pandya ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
High Intensity ◽  
Mr Angiography ◽  
Time Of Flight ◽  
Artery Stenosis ◽  
Symptomatic Carotid ◽  
High Intensity Signal

Abstract TMP33: High Intensity Signal in the Plaque on 3DTOF MRA is Associated With Ischemic Stroke in the Patients With Low Grade Carotid Artery Stenosis

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Kiyofumi Yamada ◽  
Masanori Kawasaki ◽  
Shigehiro Nakahara ◽  
Yoshikazu Sato ◽  
Kazutaka Uchida ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
High Intensity ◽  
Odds Ratio ◽  
Artery Stenosis ◽  
Low Grade ◽  
Carotid Plaques ◽  
Tof Mra ◽  
High Intensity Signal

Background: Carotid artery stenosis is one of the major causes of ischemic strokes. However, degree of stenosis is not always correlated with frequency of ischemic strokes. Recently, it was reported that carotid intraplaque hemorrhage (IPH) was associated with accelerated plaque growth, luminal narrowing and development of symptomatic events. Maximum intensity projection (MIP) images are easily reformatted within from 5 minute, routine time-of-flight (TOF) sequences. The aim of this study was to evaluate the relationships between high intensity signal (HIS) in the carotid plaques on MIP images detected by routine three-dimensional TOF magnetic resonance angiography (3D-TOF MRA) and ischemic strokes. Materials and Methods: One hundred fifty two patients with low-grade carotid artery stenosis (North American Symptomatic Carotid Endarterectomy Trial criteria: 30% - 49%) were included. IPH was defined as the presence of HIS in the carotid plaques on MIP images of 3D-TOF MRA using the previously reported criteria. We analyzed the relationship between the presence of HIS in the plaques and prior ischemic strokes defined as ischemic lesions on diffusion weighed images of the brain. Results: HIS in the carotid plaque was present in 56 (37%) of 152 carotid arteries. Prior ipsilateral ischemic strokes were observed more frequently in HIS-positive group (12 of 56, 21.4%) than HIS-negative group (1 of 34: 2.9%) [p<0.001]. In multivariate logistic regression analysis, HIS (Odds ratio: 77.7, 95%CI: 6.4 - 944.0, p<0.001) and diabetes mellitus type 2 (odds ratio: 10.45, 95%CI: 1.6 - 67.9, p=0.014) were independent determinants of prior ischemic strokes after adjustment for age. Conclusions: HIS in the carotid plaques on MIP images of 3D-TOF MRA was an independent determinant of prior ischemic stroke in patients with low-grade carotid artery stenosis, and this finding may provide a reliable risk stratification of future stroke in patients with low-grade carotid artery stenosis.

scholarly journals Carotid Artery Stenosis: Comparison of 3D Time-of-Flight MR Angiography and Contrast-Enhanced MR Angiography at 3T

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Ivan Platzek ◽  
Dominik Sieron ◽  
Philipp Wiggermann ◽  
Michael Laniado
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Mr Angiography ◽  
Carotid Arteries ◽  
Time Of Flight ◽  
Internal Carotid Artery Stenosis ◽  
Artery Stenosis ◽  
Wilcoxon Test ◽  
Tof Mra ◽  
Contrast Enhanced

Purpose. The aim of this study was to assess the correlation of 3D time-of-flight MR angiography (TOF MRA) and contrast-enhanced MR angiography (CEMRA) for carotid artery stenosis evaluation at 3T.Material and Methods. Twenty-three patients (5 f, 18 m; mean age 61 y, age range 45–78 y) with internal carotid artery stenosis detected with ultrasonography were examined on a 3.0T MR system. The MR examination included both 3D TOF MRA and CEMRA of the carotid arteries. MR images were evaluated independently by two board-certified radiologists. Stenosis evaluation was based on a five-point scale. Stenosis grades determined by TOF and CEMRA were compared using Spearman’s rank correlation coefficient and the Wilcoxon test. Cohen’s Kappa was used to evaluate interrater reliability.Results. CEMRA detected stenosis in 24 (52%) of 46 carotids evaluated, while TOF detected stenosis in 27 (59%) of 46 carotids. TOF MRA yielded significantly higher results for stenosis grade in comparison to CEMRA (P=0.014). Interrater agreement was very good for both TOF MRA (κ=0.93) and CEMRA (κ=0.93).Conclusion. At 3T, 3D TOF MRA should not be used as replacement for contrast-enhanced MRA of the carotid arteries, as it results in significantly higher stenosis grades.

Carotid artery stenosis: clinical efficacy of two-dimensional time-of-flight MR angiography.

Radiology ◽  
1992 ◽  
Vol 182 (3) ◽  
pp. 761-768 ◽  
Author(s):  
J E Heiserman ◽  
B P Drayer ◽  
E K Fram ◽  
P J Keller ◽  
C R Bird ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Clinical Efficacy ◽  
Carotid Artery Stenosis ◽  
Mr Angiography ◽  
Time Of Flight ◽  
Artery Stenosis ◽  
Two Dimensional

Mycophenolate mofetil attenuates plaque inflammation in patients with symptomatic carotid artery stenosis

2010 ◽  
Vol 211 (1) ◽  
pp. 231-236 ◽  
Author(s):  
Sander I. van Leuven ◽  
Diederik F. van Wijk ◽  
Oscar L. Volger ◽  
Jean-Paul P.M. de Vries ◽  
Chris M. van der Loos ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Artery Stenosis ◽  
Symptomatic Carotid ◽  
Plaque Inflammation
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