scholarly journals Overcoming the Clinical–MR Imaging Paradox of Multiple Sclerosis: MR Imaging Data Assessed with a Random Forest Approach

2011 ◽  
Vol 32 (11) ◽  
pp. 2098-2102 ◽  
Author(s):  
K. Kac̆ar ◽  
M.A. Rocca ◽  
M. Copetti ◽  
S. Sala ◽  
Š. Mesaroš ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Random Forest ◽  
Mr Imaging ◽  
Imaging Data

Statistics for Investigation of Multimodal MR Imaging Data and an Application to Multiple Sclerosis Patients

1996 ◽  
Vol 9 (8) ◽  
pp. 339-346 ◽  
Author(s):  
L. Fu ◽  
C. Wolfson ◽  
K. J. Worsley ◽  
N. De Stefano ◽  
D. L. Collins ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mr Imaging ◽  
Imaging Data ◽  
Multiple Sclerosis Patients

Intraoperative computed tomography registration and electromagnetic neuronavigation for transsphenoidal pituitary surgery: accuracy and time effectiveness

2011 ◽  
Vol 114 (2) ◽  
pp. 329-335 ◽  
Author(s):  
Paula Eboli ◽  
Bob Shafa ◽  
Marc Mayberg
Keyword(s):  
Mr Imaging ◽  
Operating Room ◽  
Navigation System ◽  
Surgical Techniques ◽  
Imaging Data ◽  
3D Navigation ◽  
Closure Time ◽  
Bony Landmarks ◽  
Room Time ◽  
Operating Room Time

Object The authors assessed the feasibility, anatomical accuracy, and cost effectiveness of frameless electromagnetic (EM) neuronavigation in conjunction with portable intraoperative CT (iCT) registration for transsphenoidal adenomectomy (TSA). Methods A prospective database was established for data obtained in 208 consecutive patients who underwent TSA in which the iCT/EM navigation technique was used. Data were compared with those acquired in a retrospective cohort of 65 consecutive patients in whom fluoroscope-assisted TSA had been performed by the same surgeon. All patients in both groups underwent transnasal removal of pituitary adenomas or neuroepithelial cysts, using identical surgical techniques with an operating microscope. In the iCT/EM technique–treated cases, a portable iCT scan was obtained immediately prior to surgery for registration to the EM navigation system, which did not require rigid head fixation. Preexisting (nonnavigation protocol) MR imaging studies were fused with the iCT scans to enable 3D navigation based on MR imaging data. The accuracy of the navigation system was determined in the first 50 iCT/EM cases by visual concordance of the navigation probe location to 5 preselected bony landmarks. For all patients in both cohorts, total operating room time, incision-to-closure time, and relative costs of imaging and surgical procedures were determined from hospital records. Results In every case, iCT registration was successful and preoperative MR images were fused to iCT scans without affecting navigation accuracy. There was 100% concordance between probe tip location and predetermined bony loci in the first 50 cases involving the iCT/EM technique. Total operating room time was significantly less in the iCT/EM cases (mean 108.9 ± 24.3 minutes [208 patients]) compared with the fluoroscopy group (mean 121.1 ± 30.7 minutes [65 patients]; p < 0.001). Similarly, incision-to-closure time was significantly less for the iCT/EM cases (mean 61.3 ± 18.2 minutes) than for the fluoroscopy cases (mean 71.75 ± 19.0 minutes; p < 0.001). Relative overall costs for iCT/EM technique and intraoperative C-arm fluoroscopy were comparable; increased costs for navigation equipment were offset by savings in operating room costs for shorter procedures. Conclusions The use of iCT/MR imaging–guided neuronavigation for transsphenoidal surgery is a time-effective, cost-efficient, safe, and technically beneficial technique.

Human aorta: preliminary results with virtual endoscopy based on three-dimensional MR imaging data sets.

Radiology ◽  
1996 ◽  
Vol 199 (1) ◽  
pp. 37-40 ◽  
Author(s):  
C P Davis ◽  
M E Ladd ◽  
B J Romanowski ◽  
S Wildermuth ◽  
J F Knoplioch ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Three Dimensional ◽  
Virtual Endoscopy ◽  
Human Aorta ◽  
Data Sets ◽  
Imaging Data ◽  
Preliminary Results

Proton MR Spectroscopy and MR Imaging in Acute and Chronic Multiple Sclerosis — Ringlike Appearances in Acute Plaques

1996 ◽  
Vol 37 (1P1) ◽  
pp. 278-287 ◽  
Author(s):  
A.-M. Landtblom ◽  
L. Sjöqvist ◽  
B. Söderfeldt ◽  
H. Nyland ◽  
K.-Å. Thuomas
Keyword(s):  
Multiple Sclerosis ◽  
Relaxation Time ◽  
Mr Imaging ◽  
Brain Lesions ◽  
T2 Relaxation Time ◽  
Healthy Individuals ◽  
T2 Relaxation ◽  
Proton Mrs ◽  
Proton Mr Spectroscopy ◽  
The Core

Purpose: We wanted to compare the metabolite status of brain lesions in different clinical subtypes of multiple sclerosis (MS). Two acute MS lesions with ringlike appearances were also investigated. Material and Methods: Twenty-three clinically stable MS patients, 2 patients with acute relapses, and 15 healthy individuals were examined by MR imaging and localized proton MRS. Results: No metabolite differences were seen in plaques of different subtypes. Decreased NAA/Cr and NAA/choline ratios as well as increased inositol/Cr ratios were observed in the plaques of the clinically stable or chronic active MS patients as compared with controls. The ring plaques had hyperintense cores with surrounding halos, separated from the cores by rings with low signal intensity in T2-weighted images. The core exhibited a prolonged T2 relaxation time. Proton spectra initially contained lactate. Conclusion: No differences between the metabolite status of nonacute plaques in different clinical subtypes could be detected. The ring plaques contained lactate signals indicating oedema, inflammation, and macrophage invasion, and may be transition forms between acute oedematous lesions and chronic demyelinated plaques.

scholarly journals Using magnetic resonance imaging in animal models to guide drug development in multiple sclerosis

2013 ◽  
Vol 20 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Nabeela Nathoo ◽  
V Wee Yong ◽  
Jeff F Dunn
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Clinical Trials ◽  
Magnetic Resonance ◽  
Animal Models ◽  
Mr Imaging ◽  
Preclinical Studies ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Potential Therapeutics

Major advances are taking place in the development of therapeutics for multiple sclerosis (MS), with a move past traditional immunomodulatory/immunosuppressive therapies toward medications aimed at promoting remyelination or neuroprotection. With an increase in diversity of MS therapies comes the need to assess the effectiveness of such therapies. Magnetic resonance imaging (MRI) is one of the main tools used to evaluate the effectiveness of MS therapeutics in clinical trials. As all new therapeutics for MS are tested in animal models first, it is logical that MRI be incorporated into preclinical studies assessing therapeutics. Here, we review key papers showing how MR imaging has been combined with a range of animal models to evaluate potential therapeutics for MS. We also advise on how to maximize the potential for incorporating MRI into preclinical studies evaluating possible therapeutics for MS, which should improve the likelihood of discovering new medications for the condition.

scholarly journals Differentiation of Recurrent Glioblastoma from Delayed Radiation Necrosis by Using Voxel-based Multiparametric Analysis of MR Imaging Data

Radiology ◽  
2017 ◽  
Vol 285 (1) ◽  
pp. 206-213 ◽  
Author(s):  
Ra Gyoung Yoon ◽  
Ho Sung Kim ◽  
Myeong Ju Koh ◽  
Woo Hyun Shim ◽  
Seung Chai Jung ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Radiation Necrosis ◽  
Recurrent Glioblastoma ◽  
Imaging Data ◽  
Multiparametric Analysis
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