scholarly journals Contrast-Enhancement of the Anterior Eye Segment in Patients with Retinoblastoma: Correlation between Clinical, MR Imaging, and Histopathologic Findings

2009 ◽  
Vol 31 (2) ◽  
pp. 237-245 ◽  
Author(s):  
P. de Graaf ◽  
P. van der Valk ◽  
A.C. Moll ◽  
S.M. Imhof ◽  
A.Y.N. Schouten-van Meeteren ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Enhancement ◽  
Anterior Eye Segment ◽  
Histopathologic Findings

scholarly journals MR Imaging–Pathologic Correlation of Uveal Melanomas Undergoing Secondary Enucleation after Proton Beam Radiotherapy

2021 ◽  
Vol 11 (9) ◽  
pp. 4310
Author(s):  
Pietro Valerio Foti ◽  
Corrado Inì ◽  
Mario Travali ◽  
Renato Farina ◽  
Stefano Palmucci ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Proton Beam ◽  
Uveal Melanoma ◽  
Vitreous Hemorrhage ◽  
Nerve Degeneration ◽  
Proton Beam Radiotherapy ◽  
Iris Neovascularization ◽  
Weighted Sequences ◽  
Histopathologic Findings ◽  
Optic Nerve Degeneration

Background: Currently, radiotherapy represents the most widely employed therapeutic option in patients with uveal melanoma. Although the effects of proton beam radiotherapy on uveal melanoma end ocular tissues have been histologically documented, their appearance at MR imaging is still poorly understood. The purpose of our study was to elucidate the magnetic resonance (MR) semiotics of radiotherapy-induced changes to neoplastic tissues and ocular structures in patients with uveal melanoma undergoing secondary enucleation after proton beam radiotherapy. Methods: Nine patients with uveal melanoma who had undergone proton beam radiotherapy, MR imaging, and subsequent secondary enucleation were retrospectively selected. The histopathologic findings evaluated for irradiated tumors were necrosis, fibrosis, and viable tumor, while the histopathologic findings evaluated for extratumoral ocular/periocular tissues were radiation-related intraocular inflammation, vitreous hemorrhage, optic nerve degeneration, iris neovascularization, and periocular fibrotic adhesions. On MR images, the appearance of the abovementioned histologic features was assessed on conventional and diffusion-weighted sequences. Results: T2-weighted sequences performed better in detecting radiation-induced necrosis, fibrosis, optic nerve degeneration, and periocular fibrotic adhesions. T1-weighted sequences were preferable for identifying cataracts, vitreous hemorrhage, and inflammatory complications. Contrast-enhanced T1-weighted sequences were irreplaceable in assessing iris neovascularization, and in confirming inflammatory complications. Conclusions: In the light of their increasing role in the multidisciplinary management of patients with uveal melanoma, radiologists should be aware of the MR appearance of the effects of radiotherapy on neoplastic and ocular tissue, in order to improve the accuracy of follow-up MR examinations.

Yolk–shell magnetic composite Fe3O4@Co/Zn-ZIF for MR imaging-guided chemotherapy of tumors in vivo

2021 ◽  
Author(s):  
Ying Li ◽  
Lu-Lu Jiang ◽  
Ya-Xian Qiao ◽  
Dong Wan ◽  
Yan-Feng Huang
Keyword(s):  
Mr Imaging ◽  
Contrast Enhancement ◽  
Magnetic Composite ◽  
Loading Capacity ◽  
Ph Responsive

The yolk–shell composites Fe3O4@Co/Zn-ZIF exhibited high doxorubicin loading capacity, pH-responsive release characteristics, and strong T2-weighted MR imaging contrast enhancement, and were used for MR imaging-guided chemotherapy of tumors in vivo.

Comparison of the Safety of Standard and Triple Dose Gadodiamide Injection in MR Imaging of the Central Nervous System

1994 ◽  
Vol 35 (4) ◽  
pp. 396-399 ◽  
Author(s):  
M. G. Svaland ◽  
T. Christensen ◽  
E. Lundorf
Keyword(s):  
Mr Imaging ◽  
Adverse Events ◽  
Contrast Enhancement ◽  
Dose Group ◽  
Serum Bilirubin ◽  
Diagnostic Yield ◽  
Blood Chemistry ◽  
New Information ◽  
Safety Parameters ◽  
The Central Nervous System

Gadodiamide injection was administered intravenously to 49 patients with known or suspected CNS lesions undergoing MR imaging. Two parallel groups were used to evaluate the efficacy and safety of single doses of 0.1 (25 patients) and 0.3 (24 patients) mmol/kg b.w. The principal measures of efficacy were diagnostic yield of MR and the overall contrast enhancement. Adverse events and serum bilirubin were the main safety parameters. Contrast enhancement of the lesion was observed for 16 patients in each dose group. Thirteen patients in the 0.1 and 17 in the 0.3 mmol/kg group had their diagnosis amended following the postcontrast image, but only one patient in each dose group had their management affected by new information from the postcontrast image. The overall diagnostic utility of gadodiamide injection was good, but there were no differences between the 2 doses studied in this respect. No injection-associated discomfort or other adverse events were reported. No clinically important changes in serum bilirubin, or other parameters of blood chemistry, or hematology were observed. Overall, the safety profile of gadodiamide injection 0.3 mmol/kg b.w. in this study was similar to that of 0.1 mmol/kg b.w.

MR Imaging of Hepatocellular Carcinoma

1995 ◽  
Vol 36 (2) ◽  
pp. 163-167 ◽  
Author(s):  
H. Honda ◽  
H. Onitsuka ◽  
Y. Kanazawa ◽  
T. Matsumata ◽  
T. Hayashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mr Imaging ◽  
Low Grade ◽  
Hepatic Parenchyma ◽  
Grade Ii ◽  
Paramagnetic Ions ◽  
Grade Malignancy ◽  
Histopathologic Findings ◽  
Signal Intensities ◽  
Grade Iii

In order to clarify the factors contributing to the signal intensities (SIs) of HCC on T1-weighted images, the amount of water, lipid, copper (Cu), iron (Fe), and manganese (Mn) was determined in HCC and surrounding hepatic parenchyma of 13 patients. The relationships among these findings, the histopathologic findings, and the SIs of T1-weighted images were evaluated. Among the 13 HCC, 3 had a high SI, 5 were isointense, and 5 had a low SI on T1-weighted images compared to the surrounding hepatic parenchyma. The paramagnetic ions which contributed to the SI patterns were assumed to be Cu in HCC (38.0±62.4 μg/g ww), and Fe in the liver (61.1±42.4 μg/g ww) and HCC (40.0±34.3 μg/g ww). In 8 HCC with high- or isointensity, 2 were grades I, 5 were grade II, and one was grade III according to the Edmondson-Steiner's histopathologic classification. It is concluded that the SI patterns alone can not be a sign of low grade malignancy because of the existence of Fe in livers and HCC.

scholarly journals Developing Asymmetry at Mammography: Correlation with US and MR Imaging and Histopathologic Findings

Radiology ◽  
2016 ◽  
Vol 279 (2) ◽  
pp. 385-394 ◽  
Author(s):  
Allyson L. Chesebro ◽  
Nicole S. Winkler ◽  
Robyn L. Birdwell ◽  
Catherine S. Giess
Keyword(s):  
Mr Imaging ◽  
Histopathologic Findings

Two different types of ring-like enhancement on dynamic MR imaging in breast cancer: Correlation with the histopathologic findings

2008 ◽  
Vol 28 (6) ◽  
pp. 1435-1443 ◽  
Author(s):  
Miki Kobayashi ◽  
Hiroko Kawashima ◽  
Osamu Matsui ◽  
Yoh Zen ◽  
Masayuki Suzuki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Dynamic Mr Imaging ◽  
Different Types ◽  
Histopathologic Findings ◽  
Dynamic Mr

scholarly journals Intracranial Gliomas: Association between MRI Features and Tumor Grade

2019 ◽  
Vol 8 (2) ◽  
pp. 93-99
Author(s):  
Md Rokibul Islam ◽  
KM Tarikul Islam ◽  
Moshiur Rahman ◽  
Mohammad Hossain ◽  
Raziul Haque ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Enhancement ◽  
Predictive Value ◽  
Tumor Grade ◽  
Mass Effect ◽  
Low Grade ◽  
Imaging Features ◽  
Peritumoral Edema ◽  
Cross Sectional ◽  
Mri Features

Purpose: Intracranial gliomas are not uncommon in our country. The therapeutic management and prognosis in patients with gliomas depend on the reliable distinction between high and low-grade gliomas. The purpose of the present study was to determine whether any association exists between various individual MR imaging features and histopathologically determined tumor grade of intracranial gliomas. Our target was to explore whether MRI could enable correct determination the grading of gliomas which will help early diagnosis, staging, grade assessing, determining the appropriate treatment, preoperative planning for surgical resection and post operative management plan. Materials and Methods: It was a cross sectional type of observational study. This study was conducted on 44 cases of intracranial gliomas. Only patients having histopathologically proven intracranial gliomas who underwent surgery or stereotactic biopsy were considered as a study population. Results: The present study revealed that there is significant association between the MR imaging features and histopathological grading of intracranial gliomas. Contrast enhancement in MRI showed most significant (p<0.001). Other significant MR imaging features were peritumoral edema (p=0.001), tumor border definition (p=0.001), necrosis or cystic change of tumor (p=0.001) and mass effect (p=0.003). In this study preoperative MRI diagnosis was correct in 39 patients with accuracy of 88.6%. Sensitivity, specificity, positive predictive value and negative predictive value of MRI in detecting tumor grade were 86.4%, 90.9%, 90.5% and 87% respectively. Conclusion: MRI is sensitive, specific and accurate in assessing the grade of gliomas. Contrast enhancement is the most important predictor. Peritumoral edema, tumor border definition, mass effect and necrosis/cystic changes of tumor are also important indicators of tumor grade. Bang. J Neurosurgery 2019; 8(2): 93-99

scholarly journals Gd(iii)–Pt(iv) theranostic contrast agents for tandem MR imaging and chemotherapy

2020 ◽  
Vol 11 (9) ◽  
pp. 2524-2530 ◽  
Author(s):  
Casey J. Adams ◽  
Thomas J. Meade
Keyword(s):  
Mr Imaging ◽  
Contrast Agents ◽  
Contrast Enhancement ◽  
Theranostic Agents

The first example of Gd(iii)–Pt(iv) theranostic agents that are intracellularly reduced to provide MR contrast enhancement with simultaneous Pt(ii) chemotherapy.

scholarly journals Contrast Enhancement of the Anterior Eye Segment and Subarachnoid Space: Detection in the Normal State by Heavily T2-weighted 3D FLAIR

2011 ◽  
Vol 10 (3) ◽  
pp. 193-199 ◽  
Author(s):  
Shinji NAGANAWA ◽  
Masahiro YAMAZAKI ◽  
Hisashi KAWAI ◽  
Michihiko SONE ◽  
Tsutomu NAKASHIMA
Keyword(s):  
Contrast Enhancement ◽  
Normal State ◽  
Subarachnoid Space ◽  
Anterior Eye Segment ◽  
3D Flair
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