scholarly journals Diffuse White Matter Damage Is Absent in Neuromyelitis Optica

2009 ◽  
Vol 31 (1) ◽  
pp. 76-79 ◽  
Author(s):  
F. Aboul-Enein ◽  
M. Krššák ◽  
R. Höftberger ◽  
D. Prayer ◽  
W. Kristoferitsch
Keyword(s):  
White Matter ◽  
Neuromyelitis Optica ◽  
White Matter Damage ◽  
Diffuse White Matter

Mapping white matter damage distribution in neuromyelitis optica spectrum disorders with a multimodal MRI approach

2020 ◽  
pp. 135245852094149
Author(s):  
Laura Cacciaguerra ◽  
Maria A Rocca ◽  
Loredana Storelli ◽  
Marta Radaelli ◽  
Massimo Filippi
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Fractional Anisotropy ◽  
Neuromyelitis Optica ◽  
Mean Diffusivity ◽  
Healthy Controls ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
White Matter Damage ◽  
Axial Diffusivity ◽  
Spectrum Disorders

Background: The pathogenetic mechanisms sustaining neuroinflammatory disorders may originate from the cerebrospinal fluid. Objective: To evaluate white matter damage with diffusion tensor imaging and T1/T2-weighted ratio at progressive distances from the ventricular system in neuromyelitis optica spectrum disorders and multiple sclerosis. Methods: Fractional anisotropy, mean, axial, and radial diffusivity and T1/T2-weighted ratio maps were obtained from patients with seropositive neuromyelitis optica spectrum disorders, multiple sclerosis, and healthy controls ( n = 20 each group). White matter damage was assessed as function of ventricular distance within progressive concentric bands. Results: Compared to healthy controls, neuromyelitis optica spectrum disorders patients had similar fractional anisotropy, radial and axial diffusivity, increased mean diffusivity ( p = 0.009–0.013) and reduced T1/T2-weighted ratio ( p = 0.024–0.037) in all bands. In multiple sclerosis, gradient of percentage lesion volume and intra-lesional mean and axial diffusivity were higher in periventricular bands. Compared to healthy controls, multiple sclerosis patients had reduced fractional anisotropy ( p = 0.001–0.043) in periventricular bands, increased mean ( p < 0.001), radial ( p < 0.001–0.004), and axial diffusivity ( p = 0.002–0.008) and preserved T1/T2-weighted ratio in all bands. Conclusion: White matter damage is higher at periventricular level in multiple sclerosis and diffuse in neuromyelitis optica spectrum disorders. Fractional anisotropy preservation, associated with increased mean diffusivity and reduced T1/T2-weighted ratio may reflect astrocyte damage.

Multi-parametric structural magnetic resonance imaging in relation to cognitive dysfunction in long-standing multiple sclerosis

2015 ◽  
Vol 22 (5) ◽  
pp. 608-619 ◽  
Author(s):  
Marita Daams ◽  
Martijn D Steenwijk ◽  
Menno M Schoonheim ◽  
Mike P Wattjes ◽  
Lisanne J Balk ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Cognitive Dysfunction ◽  
Cognitive Deficits ◽  
Grey Matter ◽  
White Matter Damage ◽  
Diffuse White Matter ◽  
Brain White Matter ◽  
Deep Grey Matter ◽  
Imaging Markers

Background: Cognitive deficits are common in multiple sclerosis. Most previous studies investigating the imaging substrate of cognitive deficits in multiple sclerosis included patients with relatively short disease durations and were limited to one modality/brain region. Objective: To identify the strongest neuroimaging predictors for cognitive dysfunction in a large cohort of patients with long-standing multiple sclerosis. Methods: Extensive neuropsychological testing and multimodal 3.0T MRI was performed in 202 patients with multiple sclerosis and 52 controls. Cognitive scores were compared between groups using Z-scores. Whole-brain, white matter, grey matter, deep grey matter and lesion volumes; cortical thickness, (juxta)cortical and cerebellar lesions; and extent and severity of diffuse white matter damage were measured. Stepwise linear regression was used to identify the strongest predictors for cognitive dysfunction. Results: All cognitive domains were affected in patients. Patients showed extensive atrophy, focal pathology and damage in up to 75% of the investigated white matter. Associations between imaging markers and average cognition were two times stronger in cognitively impaired patients than in cognitively preserved patients. The final model for average cognition consisted of deep grey matter DGMV volume and fractional anisotropy severity (adjusted R²=0.490; p<0.001). Conclusion: From all imaging markers, deep grey matter atrophy and diffuse white matter damage emerged as the strongest predictors for cognitive dysfunction in long-standing multiple sclerosis.

Fingolimod treatment reverses signs of diffuse white matter damage in multiple sclerosis: A pilot study

2021 ◽  
Vol 48 ◽  
pp. 102690
Author(s):  
Maija Saraste ◽  
Svetlana Bezukladova ◽  
Marcus Sucksdorff ◽  
Virva Saunavaara ◽  
Eero Rissanen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Pilot Study ◽  
White Matter Damage ◽  
Diffuse White Matter

Pathogenesis of Normal-appearing White Matter Damage in Neuromyelitis Optica: Diffusion-Tensor MR Imaging

Radiology ◽  
2008 ◽  
Vol 246 (1) ◽  
pp. 222-228 ◽  
Author(s):  
Chunshui Yu ◽  
Fuchun Lin ◽  
Kuncheng Li ◽  
Tianzi Jiang ◽  
Wen Qin ◽  
...  
Keyword(s):  
White Matter ◽  
Mr Imaging ◽  
Neuromyelitis Optica ◽  
Diffusion Tensor ◽  
White Matter Damage ◽  
Normal Appearing White Matter ◽  
Diffusion Tensor Mr Imaging

In vivo assessment of white matter damage in neuromyelitis optica: A diffusion tensor and diffusion kurtosis MR imaging study

2014 ◽  
Vol 345 (1-2) ◽  
pp. 172-175 ◽  
Author(s):  
Margareth Cristina Goncalves Kimura ◽  
Thomas Martin Doring ◽  
Fernanda Cristina Rueda ◽  
Gustavo Tukamoto ◽  
Emerson Leandro Gasparetto
Keyword(s):  
White Matter ◽  
Mr Imaging ◽  
Neuromyelitis Optica ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
White Matter Damage ◽  
Diffusion Kurtosis ◽  
And Diffusion ◽  
In Vivo Assessment

Accumulation of 4-hydroxy-2-nonenal-modified proteins in the white matter damage in chronic cerebral hypo-perfusion rat mode

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S262-S262
Author(s):  
Terubumi Watanabe ◽  
Yoshiko Yanagi ◽  
Takao Urabe ◽  
Yoshikuni Mizuno
Keyword(s):  
White Matter ◽  
White Matter Damage ◽  
Modified Proteins

Cognitive dysfunctions associated with white matter damage due to cardiovascular burden – determinants and interpretations

2014 ◽  
Vol 45 (3) ◽  
pp. 334-345 ◽  
Author(s):  
Paweł Krukow
Keyword(s):  
Cerebral Cortex ◽  
White Matter ◽  
Cardiovascular Diseases ◽  
Cognitive Disorder ◽  
Theoretical Background ◽  
Dynamic Aspect ◽  
Pathological Changes ◽  
White Matter Damage ◽  
Neuropsychological Disorders ◽  
Considerable Research

AbstractAlthough considerable research has been devoted to cognitive functions deteriorating due to diseases of cardiovascular system, rather less attention has been paid to their theoretical background. Progressive vascular disorders as hypertension, atherosclerosis and carotid artery stenosis generate most of all pathological changes in the white matter, that cause specific cognitive disorder: disconnection syndromes, and disturbances in the dynamic aspect of information processing. These features made neuropsychological disorders secondary to cardiovascular diseases different than the effects of cerebral cortex damage, which may be interpreted modularly.

A Girl of Unusual Diffuse White Matter and Basal Ganglia Lesions Following Streptococcus Pneumoniae Meningoencephalitis

2016 ◽  
Vol 24 (4) ◽  
pp. 266-271
Author(s):  
이훈상 ◽  
이윤진 ◽  
김영미 ◽  
Yeon Gyu Min ◽  
김경민 ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
White Matter ◽  
Basal Ganglia ◽  
Diffuse White Matter
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