scholarly journals Characteristics of Abnormal Diffusivity in Normal-Appearing White Matter Investigated with Diffusion Tensor MR Imaging in Tuberous Sclerosis Complex

2007 ◽  
Vol 28 (9) ◽  
pp. 1662-1667 ◽  
Author(s):  
M.I. Makki ◽  
D.C. Chugani ◽  
J. Janisse ◽  
H.T. Chugani
Keyword(s):  
White Matter ◽  
Mr Imaging ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Diffusion Tensor ◽  
Normal Appearing White Matter ◽  
Diffusion Tensor Mr Imaging

Pathogenesis of Normal-appearing White Matter Damage in Neuromyelitis Optica: Diffusion-Tensor MR Imaging

Radiology ◽  
2008 ◽  
Vol 246 (1) ◽  
pp. 222-228 ◽  
Author(s):  
Chunshui Yu ◽  
Fuchun Lin ◽  
Kuncheng Li ◽  
Tianzi Jiang ◽  
Wen Qin ◽  
...  
Keyword(s):  
White Matter ◽  
Mr Imaging ◽  
Neuromyelitis Optica ◽  
Diffusion Tensor ◽  
White Matter Damage ◽  
Normal Appearing White Matter ◽  
Diffusion Tensor Mr Imaging

A quantitative evaluation of damage in normal appearing white matter in patients with multiple sclerosis using diffusion tensor MR imaging at 3 T

2014 ◽  
Vol 115 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Georgios Gratsias ◽  
Eftychia Kapsalaki ◽  
Styliani Kogia ◽  
Efthimios Dardiotis ◽  
Vaia Tsimourtou ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Mr Imaging ◽  
Quantitative Evaluation ◽  
Diffusion Tensor ◽  
Normal Appearing White Matter ◽  
Diffusion Tensor Mr Imaging

Diffusion-Weighted MR Imaging in the Evaluation of Normal Appearing White Matter in Patients with Tuberous Sclerosis

2003 ◽  
Vol 16 (2) ◽  
pp. 263-266
Author(s):  
F.G. Garaci ◽  
R. Floris ◽  
G. Manenti ◽  
L.M. Fantozzi ◽  
A. Bozzao
Keyword(s):  
White Matter ◽  
Mr Imaging ◽  
Tuberous Sclerosis ◽  
Centrum Semiovale ◽  
Normal Appearing White Matter ◽  
Diffusion Weighted ◽  
Adc Values ◽  
Mr Sequences ◽  
Supratentorial White Matter

The aim of the present study was to assess the presence of changes in diffusivity in the brains of patients with tuberous sclerosis (TS) in areas free from signal alterations on conventional MR sequences. Ten patients and controls were evaluated. ROI were placed on ADC maps in the white matter (frontal, parietal and centrum semiovale) excluding areas with signal alterations on FLAIR images. ADC values of supratentorial white matter turned out to be higher than controls (P < .0001). Our data indicate that TS is more widely diffused than expected in the brains of affected patients.

scholarly journals Early white matter development is abnormal in tuberous sclerosis complex patients who develop autism spectrum disorder

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Anna K. Prohl ◽  
◽  
Benoit Scherrer ◽  
Xavier Tomas-Fernandez ◽  
Peter E. Davis ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Neural Circuits ◽  
Diffusion Tensor ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Fiber Bundles ◽  
The Brain

Abstract Background Autism spectrum disorder (ASD) is prevalent in tuberous sclerosis complex (TSC), occurring in approximately 50% of patients, and is hypothesized to be caused by disruption of neural circuits early in life. Tubers, or benign hamartomas distributed stochastically throughout the brain, are the most conspicuous of TSC neuropathology, but have not been consistently associated with ASD. Widespread neuropathology of the white matter, including deficits in myelination, neuronal migration, and axon formation, exist and may underlie ASD in TSC. We sought to identify the neural circuits associated with ASD in TSC by identifying white matter microstructural deficits in a prospectively recruited, longitudinally studied cohort of TSC infants. Methods TSC infants were recruited within their first year of life and longitudinally imaged at time of recruitment, 12 months of age, and at 24 months of age. Autism was diagnosed at 24 months of age with the ADOS-2. There were 108 subjects (62 TSC-ASD, 55% male; 46 TSC+ASD, 52% male) with at least one MRI and a 24-month ADOS, for a total of 187 MRI scans analyzed (109 TSC-ASD; 78 TSC+ASD). Diffusion tensor imaging properties of multiple white matter fiber bundles were sampled using a region of interest approach. Linear mixed effects modeling was performed to test the hypothesis that infants who develop ASD exhibit poor white matter microstructural integrity over the first 2 years of life compared to those who do not develop ASD. Results Subjects with TSC and ASD exhibited reduced fractional anisotropy in 9 of 17 white matter regions, sampled from the arcuate fasciculus, cingulum, corpus callosum, anterior limbs of the internal capsule, and the sagittal stratum, over the first 2 years of life compared to TSC subjects without ASD. Mean diffusivity trajectories did not differ between groups. Conclusions Underconnectivity across multiple white matter fiber bundles develops over the first 2 years of life in subjects with TSC and ASD. Future studies examining brain-behavior relationships are needed to determine how variation in the brain structure is associated with ASD symptoms.

Differences between Gray Matter and White Matter Water Diffusion in Stroke: Diffusion-Tensor MR Imaging in 12 Patients

Radiology ◽  
2000 ◽  
Vol 215 (1) ◽  
pp. 211-220 ◽  
Author(s):  
Pratik Mukherjee ◽  
Mark M. Bahn ◽  
Robert C. McKinstry ◽  
Joshua S. Shimony ◽  
Thomas S. Cull ◽  
...  
Keyword(s):  
White Matter ◽  
Mr Imaging ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Water Diffusion ◽  
Diffusion Tensor Mr Imaging
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