Serial Haemodynamic Change In Children With Acute Empyema
Empyema thoracis continues to remain a serious complication of Pneumonia in children. A number ofstudies are available on demographics, etiology and treatment of empyema but no useful information isavailable on hemodynamic changes occurring in response to acute empyema. Therefore we aimed to evaluatethe serial haemodynamic changes in children with acute empyema and their correlation with severity andout come of the disease.Serial haemodynamic changes were studied prospectively in 25 children with acute empyema before andafter the placement of chest tube and subsequently on day 1, 2, 3 and 10 of hospitalization. Twenty-five ageand sex matched children served as their controls.Their age ranged from 8 months to 12 years (mean 4.2 years). Severity of empyema was graded as mild,moderate and severe in 11, 6 and 8 children respectively. Staphylococcus aureus was the commonestorganism isolated in 11 children. At admission all the children were febrile (mean temp 39.4C) hadtachycardia (mean HR136/mt) and tachypnea (mean RR 62/mt).While CVP was high (10.2? 4cm H2O), thesystolic (102 ? 4mmHg) and mean arterial pressure(77? 3mmHg) was at lower side as compared to theircontrols.The mean changes observed after the chest tube placement were HR- 6/mt; RR - 4.44/ mt; SBP+5mmHg; DBP +2.04mmHg; MAP +3mmHg and CVP-3.1cm H2o (p <.001). Children with severe diseasehad significantly higher CVP (15 ? 3.3cmH2o), low SBP (99 ? 3mmHg) and low serum Sodium (128? 5mEq/L) and Osmolality (278 ? 9 mOsm/L) compared to those with mild or moderate disease. (p<.05 foreach factor).Seven children had features suggestive of syndrome of inappropriate ADH secretion. All thischildren belonged to severe category.It was concluded that hemodynamic compromise is a common occurrence in children with empyema. HighCVP, low SBP, low serum Na+ and Osmolality correlate best with the severity of the disease.Key Words: Empyema, Hemodynamics, Children.