scholarly journals Markel Cell Carcinoma

2010 ◽  
Vol 49 (178) ◽  
Author(s):  
S Wallis ◽  
A Durham-hall ◽  
N Tondon ◽  
TM Brotherstone ◽  
BM Shrestha
Keyword(s):  
Cell Carcinoma ◽  
Neuroendocrine Tumour ◽  
Basal Layer ◽  
Metastatic Potential ◽  
Hair Follicles ◽  
High Rate ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Review Of The Literature ◽  
Poor Outcomes

Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine tumour of the skin with high rate of local recurrence and distant metastatic potential leading to poor outcomes. Merkel cells are normally found as innervated clusters of cells around hair follicles in the basal layer of the epidermis and are thought to function as touch receptors. Here, we describe a case of MCC in a 71-year-old female and provide an up-to-date review of the literature pertinent to the management of MCC. KEYWORDS: merkell cell carcinoma, diagnosis, imunohistochemistry, management.

Localization of Merkel cells at hairless and hairy human skin sites using keratin 18

1995 ◽  
Vol 73 (9-10) ◽  
pp. 635-639 ◽  
Author(s):  
Julie Fradette ◽  
Marie-Josée Godbout ◽  
Martine Michel ◽  
Lucie Germain
Keyword(s):  
Human Skin ◽  
Basal Layer ◽  
Sensory Nerve ◽  
Neurosecretory Cells ◽  
Nerve Fibers ◽  
Hair Follicles ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Skin Receptor ◽  
And Function

Merkel cells are neurosecretory cells of the skin with epithelial features such as desmosomes and expression of keratins 8, 18, 19, and 20. Merkel cells are scarcely distributed in adult human skin. Although they are present in hair follicles, their density is higher at hairless anatomic sites such as palms and soles. These cells are often innervated by sensory nerve fibers and are thought to be specialized mechanosensory skin receptor cells. However, their precise origin and function are not clearly established. The aim of this study was to localize Merkel cells in human hairless and hairy skin by immunohistochemistry with antibodies Ks18.174 and Ks19.1 directed against keratins 18 and 19, respectively. In glabrous skin of palm and sole, Merkel cells have been localized at the bottom of the rete ridges, in the epidermal basal layer. To study Merkel cell distribution at hairy anatomic sites, we have chosen breast skin, a tissue containing small hair follicles typical of those covering most of the body's surface. Merkel cells were present in the interfollicular epidermis. In hair follicles, they have been identified in the isthmus region.Key words: skin, human, Merkel cell, keratin, hair follicle.

scholarly journals Merkel cell carcinoma masquerading as cellulitis: a case report and review of the literature

2018 ◽  
Vol 25 (1) ◽  
pp. 106 ◽  
Author(s):  
F. Safa ◽  
M. Pant ◽  
C. Weerasinghe ◽  
R. Felix ◽  
T. Terjanian
Keyword(s):  
Clinical Trials ◽  
Case Report ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Metastatic Disease ◽  
Early Stage ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Review Of The Literature ◽  
Presumptive Diagnosis

Merkel cell carcinoma (mcc) is an uncommon malignancy of the skin arising from cells located in the deeper layers of the epidermis called Merkel cells. This malignancy rarely presents as a metastatic disease, and the field is therefore deficient in regards to management. We report the case of a 49-year-old woman who presented with a presumptive diagnosis of osteomyelitis of the left fifth digit that was resistant to treatment with antibiotics; she underwent debridement of the digit that revealed mcc and was later to have metastatic disease to her lungs, liver, and musculoskeletal system. The management of mcc, although simple in the early stage of the disease, can become challenging when it is more advanced. Multiple new modalities for its treatment have emerged over the last few years, and more recently, clinical trials are being conducted for the use of immunotherapy agents in the treatment of this malignancy.

BOWENOID BASAL CELL CARCINOMA OF THE THUMB: A CASE REPORT AND REVIEW OF THE LITERATURE

Hand Surgery ◽  
2002 ◽  
Vol 07 (02) ◽  
pp. 295-298 ◽  
Author(s):  
M. Galeano ◽  
M. Colonna ◽  
M. Lentini ◽  
F. Stagno D'Alcontres
Keyword(s):  
Case Report ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Basal Layer ◽  
Rare Entity ◽  
Review Of The Literature ◽  
Skin Malignancy ◽  
Root Sheath ◽  
Common Skin

Basal cell carcinoma (BCC) is the most common skin malignancy arising from cells of the basal layer of the epithelium or from the external root sheath of the hair follicle. BCC of the digit is a rare entity. The article presents one such case of bowenoid BCC of the thumb which required amputation at the MP joint.

Metastasis of cancer from Merkel cells to the thyroid gland

2021 ◽  
Vol 19 (1) ◽  
pp. 86-88
Author(s):  
Piotr Przyczyna ◽  
◽  
Elżbieta Trojnar ◽  
Dorota Bartusik-Aebisher ◽  
David Aebisher ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Thyroid Cancer ◽  
Thyroid Gland ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Uterine Fibroids ◽  
Degenerative Changes ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Left Buttock

Introduction. Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer. Aim. Herein described is a case of hypertensive patient, after removal of Merkel cancer of the left gluteus skin (2011), after pulmonary embolism (2013), with degenerative changes of the spine and uterine myoma, chronically treated with Warfarin, because of suspected thyroid cancer. Description of the case. A 70-year-old woman case after removing Merkel cancer of the left buttock skin (2011), after pulmonary embolism (2013), with degenerative changes of the spine and uterine fibroids treated chronically with Warfarin because of suspected thyroid cancer is described. Conclusion. Increasing evidence of Merkel cell carcinoma with immunodeficiency and neoplasia, and the management and outcome of these patients requires study.

Merkel Cell Carcinoma of the Eyelid: A Case Report

2000 ◽  
Vol 10 (2) ◽  
pp. 173-176 ◽  
Author(s):  
L. Collaço ◽  
J.P. Silva ◽  
M. Gonçalves ◽  
P. Abrantes
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Neuroendocrine Tumour ◽  
The Elderly ◽  
Primary Site ◽  
Wide Resection ◽  
Merkel Cell ◽  
Unique Case ◽  
Upper Eyelid

A 22-year-old woman who presented with a tumour of the upper eyelid with clinical, histological, immunohistochemical and ultrastructural features of a Merkel cell carcinoma is reported. This is a unique case of Merkel cell carcinoma in such a young patient. This neuroendocrine tumour is typically found in the elderly. It can grow rapidly, has the potential for local recurrence and early metastatic spread. The authors recommend wide resection of the primary site, which proved effective in this case.

scholarly journals Nuclear medicine techniques in Merkel cell carcinoma: A case report and review of the literature

2015 ◽  
Vol 10 (3) ◽  
pp. 1610-1616 ◽  
Author(s):  
NIKOLAOS KRITIKOS ◽  
DIMITRIOS PRIFTAKIS ◽  
STAVROS STAVRINIDES ◽  
STEFANOS KLEANTHOUS ◽  
ELENI SARAFIANOU
Keyword(s):  
Nuclear Medicine ◽  
Case Report ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell ◽  
Review Of The Literature

Merkel Cell Carcinoma: A Presentation of 5 Cases and a Review of the Literature

2011 ◽  
Vol 62 (4) ◽  
pp. 306-310
Author(s):  
Pablo Santos Gorjón ◽  
Ana Cristina Morales Martín ◽  
Pedro Blanco Pérez ◽  
Juan Luis Gómez González ◽  
Juan Carlos del Pozo de Dios ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell ◽  
Review Of The Literature
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