scholarly journals Endoscopic thoracic microdiscectomy

2005 ◽  
Vol 18 (3) ◽  
pp. 1-8 ◽  
Author(s):  
Rod J. Oskouian ◽  
J. Patrick Johnson
Keyword(s):  
Operating Time ◽  
Length Of Hospital Stay ◽  
Outcome Data ◽  
Narcotic Drug ◽  
Neurological Outcomes ◽  
Long Term Follow Up ◽  
Thoracic Disc ◽  
Frankel Grade

Object The purpose of this investigation was to evaluate surgical and neurological outcomes in thoracic disc surgery in a prospective fashion. Methods Quantifiable outcome data such as operating time, blood loss, duration of chest tube drainage, narcotic drug use, length of hospital stay (LOS), and long-term follow up of neurological function and pain-related symptoms were collected prospectively. In patients with myelopathy there was an improvement of two Frankel grades in the thoracoscopic discectomy group and one Frankel grade in the patients treated with thoracotomy; however, patients in the thoracotomy group were significantly worse preoperatively. None of the patients experienced worsened pain, and pain related to radiculopathy was improved by 75% in the thoracoscopic group. Conclusions Thoracoscopic discectomy yields acceptable surgical results and has several distinct advantages, with reduced postoperative pain, morbidity, and LOS.

Endoscopic thoracic microdiscectomy

2005 ◽  
Vol 3 (6) ◽  
pp. 459-464 ◽  
Author(s):  
Rod J. Oskouian ◽  
J. Patrick Johnson
Keyword(s):  
Hospital Length ◽  
Outcome Data ◽  
Hospital Length Of Stay ◽  
Content Type ◽  
Neurological Outcomes ◽  
Long Term Follow Up ◽  
Thoracic Disc ◽  
Fine Print

Object. The purpose of this clinical study was to evaluate prospectively surgical and neurological outcomes after endoscopic thoracic disc surgery. Methods. The authors assessed the following quantifiable outcome data in 46 patients: operative time, blood loss, duration of chest tube insertion, narcotic use, hospital length of stay (LOS), and long-term follow-up neurological function and pain-related symptoms. In patients who presented with myelopathy there was a postoperative improvement of two Frankel grades. Pain related to radiculopathy was improved by 75% and in one patient it worsened postoperatively. The authors also present operative data, surgical outcomes, and complications. Conclusions. Thoracoscopic discectomy can be used to achieve acceptable results. It has several distinct advantages such as reduced postoperative pain, morbidity, and LOS compared with traditional open procedures.

Long-term seizure outcome following surgery for dysembryoplastic neuroepithelial tumor

2006 ◽  
Vol 104 (1) ◽  
pp. 62-69 ◽  
Author(s):  
Chow Huat Chan ◽  
Richard G. Bittar ◽  
Gavin A. Davis ◽  
Renate M. Kalnins ◽  
Gavin C. A. Fabinyi
Keyword(s):  
Outcome Data ◽  
Temporal Lobectomy ◽  
Class I ◽  
Surgical Removal ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Seizure Outcome ◽  
Short Term ◽  
Long Term Follow Up

Object Resection of dysembryoplastic neuroepithelial tumor (DNET) is thought to result in favorable seizure outcome, but long-term follow-up data are scarce. The authors present a review of 18 patients who underwent surgical removal of a DNET: 12 via temporal lobectomy and six via lesionectomy. Methods The mean long-term follow up was 10.8 years (median 10.4 years, range 7.8 to 14.8 years), and results obtained during this time period were compared with previously reported short-term (mean 2.7 years) seizure outcome data. In the current study, 66.7% patients had an Engel Class I outcome and 55.6% had an Engel Class IA outcome compared with 77.8% and 55.6%, respectively. Temporal lobectomy (Engel Class I, 83.3%; Engel Class IA, 66.7%) led to a better seizure outcome than lesionectomy (Engel Classes I and IA, 33.3%). Two patients (11.1%) required repeated operation and both had an incomplete lesionectomy initially. Conclusions Results indicated that complete resection of a DNET leads to a favorable seizure outcome, with epilepsy cure in those who had experienced early postoperative seizure relief. Long-term seizure outcome after surgery is predictable based on the result of short-term follow up.

scholarly journals Clinical efficacy of single intraoperative 500 mg methylprednisolone management therapy for thoracic myelopathy caused by ossification of the ligamentum flavum

2020 ◽  
Author(s):  
Xiaoyang Huo ◽  
Jiaming Zhou ◽  
Shiwei Liu ◽  
Xing Guo ◽  
Yuan Xue
Keyword(s):  
Posterior Approach ◽  
Ligamentum Flavum ◽  
Nerve Function ◽  
Thoracic Myelopathy ◽  
Time Points ◽  
Before And After ◽  
Long Term Follow Up ◽  
Frankel Grade

Abstract Background The objective of our study was to compare clinical outcome and postoperative complications between patients with thoracic myelopathy caused by ossification of the ligamentum flavum (OLF) treated with and without intraoperative methylprednisolone (MP).Methods This retrospective study enrolled 101 patients who underwent posterior approach surgery for OLF and were followed up at least 1 year. Patients were divided into two groups according to MP use in the operation: MP group (n=47) and non-MP group (n=54). Clinical outcomes and complications were evaluated before and after operation and at the last follow-up.Results Significant differences were found in modified Japanese Orthopedics Association (mJOA) scores and proportion of Frankel grade (A-C) between the two groups immediately after surgery and at 2-week follow-up. No significant differences were found between the two groups in mJOA score before operation and at the final follow-up. Moreover, no significant differences were observed in recovery rate according to mJOA score at any time points, and there were no significant differences in the proportion of Frankel grade between the two groups. There were 13 documented infections: 10 in the MP group and 3 in the non-MP group ( P =0.034).Conclusion Management therapy with intraoperative 500 mg methylprednisolone promoted the recovery of nerve function within 2 weeks in patients with thoracic myelopathy caused by OLF. However, long-term follow-up results showed that intraoperative methylprednisolone was inefficient. Moreover, intraoperative methylprednisolone increased the rate of wound infection.

scholarly journals Clinical efficacy of single intraoperative 500 mg methylprednisolone management therapy for thoracic myelopathy caused by ossification of the ligamentum flavum

2020 ◽  
Author(s):  
Xiaoyang Huo ◽  
Jiaming Zhou ◽  
Shiwei Liu ◽  
Xing Guo ◽  
Yuan Xue
Keyword(s):  
Posterior Approach ◽  
Ligamentum Flavum ◽  
Thoracic Myelopathy ◽  
Time Points ◽  
Significant Difference ◽  
Before And After ◽  
Long Term Follow Up ◽  
Frankel Grade

Abstract Background: The objective of our study was to compare clinical outcome and postoperative complications between patients with thoracic myelopathy caused by ossification of the ligamentum flavum (OLF) treated with and without intraoperative methylprednisolone (MP).Methods: This retrospective study enrolled 101 patients who underwent posterior approach surgery for OLF and were followed up at least 1 year. Patients were divided into two groups according to MP use in the operation: MP group (n=47) and non-MP group (n=54). Clinical outcomes and complications were evaluated before and after operation and at the last follow-up. Results: Significant differences were found in modified Japanese Orthopedics Association (mJOA) scores and proportion of Frankel grade (A-C) between the two groups immediately after surgery and at 2-week follow-up. No significant differences were found between the two groups in mJOA score before operation and at the final follow-up. Moreover, no significant differences were observed in recovery rate according to mJOA score at any time points, and there was no significant difference in the proportion of Frankel grade (A-C) between the two groups at final follow-up. There were 13 documented infections: 10 in the MP group and 3 in the non-MP group (P=0.034).Conclusion: Management therapy with intraoperative 500 mg MP showed better recovery of nerve function within 2 weeks in patients with thoracic myelopathy caused by OLF compared with those did not receive MP. However, long-term follow-up results showed that there was no significant difference in neurological recovery between patients with intraoperative MP or not. Moreover, intraoperative MP increased the rate of wound infection.

Long-Term Surveillance and Life-Time Care for Pediatric Patients Suffering from Hydrocephalus

2020 ◽  
Vol 18 (06) ◽  
pp. 297-300
Author(s):  
Matthias Krause ◽  
Andreas Merkenschlager ◽  
Cynthia Vanessa Mahr ◽  
Matthias K. Bernhard ◽  
Ekkehard M. Kasper ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Life Time ◽  
Outcome Data ◽  
Continuous Treatment ◽  
Childhood And Adolescence ◽  
Long Term Follow Up ◽  
Optimal Setting ◽  
Screening Intervals

AbstractEven though shunt surgery has been an established and widely accepted treatment for congenital hydrocephalus for five decades, long-term follow-up and functional outcome data are scarce. Based on our experience, we advocate a very rigid follow-up regimen throughout life for every hydrocephalus patient encountered with individual screening intervals not longer than 1 year in childhood and adolescence and surveillance intervals of 2 years in adulthood. A continuous treatment of the patients at the primary institution that performed hydrocephalus surgery provides an optimal setting to be prepared for the detection of adverse events of shunt malfunctioning. However, some patients may still encounter catastrophic events resulting in persistent deficits or death.

Results after long-term follow-up from the CAN2007 phase I/II study of weekly or twice-weekly bortezomib in patients (pts) with relapsed systemic light-chain (AL) amyloidosis.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 8545-8545
Author(s):  
Donna Ellen Reece ◽  
Ute Hegenbart ◽  
Vaishali Sanchorawala ◽  
Giampaolo Merlini ◽  
Giovanni Palladini ◽  
...  
Keyword(s):  
Single Agent ◽  
Maximum Tolerated Dose ◽  
Outcome Data ◽  
Al Amyloidosis ◽  
Background Data ◽  
Long Term Follow Up ◽  
Combination Regimens ◽  
Clinical Trial Information

8545 Background: Data from multiple studies suggest that bortezomib alone or in combination regimens is active in newly diagnosed and relapsed AL. CAN2007 (NCT00298766) was the first prospective study of single-agent bortezomib in relapsed AL. Here we report outcome data at study closure after a median follow-up of 51.8 mos (median 46.1–66.1 mos). Methods: 70 pts received bortezomib 0.7, 1.0, 1.3, or 1.6 mg/m2 on days 1, 8, 15, and 22 of 35-day cycles (QW) or 0.7, 1.0, or 1.3 mg/m2 on days 1, 4, 8, and 11 of 21-day cycles (BIW) for up to 8 cycles (or longer in pts with evidence of ongoing clinical benefit). The maximum tolerated dose was not reached on either schedule; 18 and 34 pts were treated at the maximum planned doses of 1.6 mg/m2 QW and 1.3 mg/m2BIW, respectively, and 18 pts were treated at lower doses. Post-treatment, pts were followed every 6 weeks until disease progression, and then every 3 mos for survival during the long-term follow-up phase. Results: Pts received a median (range) of 8 (1–39), 6 (1–57), and 8 (3–57) cycles of bortezomib in the 1.6 mg/m2 QW, 1.3 mg/m2 BIW, and lower-dose groups, respectively; overall, 32 (46%) pts received ≥8 cycles, and 4 pts were still on treatment and had received ≥39 cycles at study closure. Hematologic responses and outcomes are summarized below. Median (range) follow-up for survival was 51.8 (1–68), 46.1 (1–61), and 66.1 (2–80) mos, and 7, 12, and 9 pts have died, in the 1.6 mg/m2 QW, 1.3 mg/m2BIW, and lower-dose groups, respectively. Median overall survival (OS) in all 70 pts was 62.7 mos, and 4-yr OS rate was 67.3%; data by dose group are shown below. Conclusions: Single-agent bortezomib produces durable hematologic responses and promising long-term OS data in pts with relapsed AL. Clinical trial information: NCT00298766. [Table: see text]

The outcome of tethered cord release in secondary and multiple repeat tethered cord syndrome

2009 ◽  
Vol 4 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Wajd N. Al-Holou ◽  
Karin M. Muraszko ◽  
Hugh J. Garton ◽  
Steven R. Buchman ◽  
Cormac O. Maher
Keyword(s):  
Spinal Cord ◽  
Primary Repair ◽  
Tethered Cord ◽  
Tethered Cord Syndrome ◽  
Neurological Outcomes ◽  
Younger Age ◽  
Long Term Follow Up ◽  
Multiple Repeat

Object After primary repair of a myelomeningocele or a lipomyelomeningocele, patients can present with symptoms of secondary tethered cord syndrome (TCS). After surgical untethering, a small percentage of these patients can present with multiple repeat TCS. In patients presenting with secondary or multiple repeat TCS, the role as well the expected outcomes of surgical untethering are not well defined. Methods Eighty-four patients who underwent spinal cord untethering after at least 1 primary repair were retrospectively evaluated using scaled and subjective outcome measures at short-term and long-term follow-up visits. Outcomes were analyzed for predictive measures using multivariate logistic regression. Results Surgical untethering was performed in 66 patients with myelomeningoceles and 18 patients with lipomyelomeningoceles. Fourteen patients underwent multiple repeat spinal cord untethering. Patients were followed up for an average of 6.2 years. Most patients had stability of function postoperatively. Motor function and weakness improved in 7 and 16% of patients at 6 months, respectively, and 6 and 19% of patients at long-term follow-up evaluation, respectively. Of the patients who presented with back pain, 75% had improvement in symptoms at 6 months postoperatively. Younger age at untethering was significantly associated with worse long-term neurological outcomes. The number of previous untethering procedures, original diagnosis, sex, anatomical level, and degree of untethering had no effect on surgical outcomes. Conclusions Patients presenting with secondary or multiple repeat TCS may benefit from surgical untethering.

scholarly journals Endovascular Treatment of Patients with Popliteal Artery Aneurysms (a Literature Review)

2020 ◽  
Vol 8 (4) ◽  
pp. 437-442
Author(s):  
S. A. Prozorov
Keyword(s):  
Endovascular Treatment ◽  
Popliteal Artery ◽  
Length Of Hospital Stay ◽  
Wound Complication ◽  
Clinical Results ◽  
Conflicts Of Interests ◽  
Stent Grafts ◽  
Long Term Follow Up

The purpose of this review is to evaluate the results endovascular treatment of popliteal artery aneurysms. Endovascular treatment using stent grafts is a safe and effective alternative to open surgical repair, has a lower wound complication rate and shorter length of hospital stay, satisfactory technical and clinical results even at long-term follow-up. In patients requiring long segment coverage or numerous stents, the poor state of distal blood flow may increase the risk of failure. Careful patient selection, proper operative technique and adequate sizes of stent grafts are required for good outcomes.Author declare lack of the conflicts of interests.

Reversible propriospinal myoclonus due to thoracic disc herniation: Long-term follow-up

2012 ◽  
Vol 313 (1-2) ◽  
pp. 32-34 ◽  
Author(s):  
Wooyoung Jang ◽  
Joong-Seok Kim ◽  
Jin Young Ahn ◽  
Hee-Tae Kim
Keyword(s):  
Disc Herniation ◽  
Thoracic Disc Herniation ◽  
Long Term Follow Up ◽  
Thoracic Disc ◽  
Propriospinal Myoclonus
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