scholarly journals High-intensity focused ultrasound: past, present, and future in neurosurgery

2018 ◽  
Vol 44 (2) ◽  
pp. E16 ◽  
Author(s):  
Syed A. Quadri ◽  
Muhammad Waqas ◽  
Inamullah Khan ◽  
Muhammad Adnan Khan ◽  
Sajid S. Suriya ◽  
...  
Keyword(s):  
Clinical Trials ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Therapeutic Modality ◽  
Great Opportunity ◽  
Minimal Invasiveness ◽  
Novel Technology ◽  
Near Future ◽  
Modern Era

Since Lynn and colleagues first described the use of focused ultrasound (FUS) waves for intracranial ablation in 1942, many strides have been made toward the treatment of several brain pathologies using this novel technology. In the modern era of minimal invasiveness, high-intensity focused ultrasound (HIFU) promises therapeutic utility for multiple neurosurgical applications, including treatment of tumors, stroke, epilepsy, and functional disorders. Although the use of HIFU as a potential therapeutic modality in the brain has been under study for several decades, relatively few neuroscientists, neurologists, or even neurosurgeons are familiar with it. In this extensive review, the authors intend to shed light on the current use of HIFU in different neurosurgical avenues and its mechanism of action, as well as provide an update on the outcome of various trials and advances expected from various preclinical studies in the near future. Although the initial technical challenges have been overcome and the technology has been improved, only very few clinical trials have thus far been carried out. The number of clinical trials related to neurological disorders is expected to increase in the coming years, as this novel therapeutic device appears to have a substantial expansive potential. There is great opportunity to expand the use of HIFU across various medical and surgical disciplines for the treatment of different pathologies. As this technology gains recognition, it will open the door for further research opportunities and innovation.

scholarly journals Extracorporeal Ultrasound-Guided High Intensity Focused Ultrasound: Implications from the Present Clinical Trials

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Tinghe Yu ◽  
Xiao Fu
Keyword(s):  
Clinical Trials ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Combined Therapy ◽  
Clinical Findings ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Guided ◽  
The Past ◽  
Liver Cancers ◽  
Almost All

Extracorporeal ultrasound-guided high intensity focused ultrasound (HIFU) has been clinically used for 15 years, and over 36000 cases have been reported. However, there yet lacked a consensus in the clinical values, suggesting the necessity of checking clinical findings. Clinical trials were searched and data reevaluated. HIFU was hardly performed alone; almost all present anticancer means have been applied during an HIFU treatment, and a specific regimen varied between trials; there were heterogeneity and disagreement between trials. The complexity made it difficult to distinguish the effect of HIFU. Based upon evaluable data, the efficacy of HIFU was similar to that of radio frequency, chemoembolization, chemotherapy, radiotherapy, or hormone therapy; a combined therapy did not improve the efficacy. The survival rate of HIFU plus radiotherapy was lower than that of radical surgery in liver cancers. Adverse events had no downtrend in the past years. HIFU was not a standardized procedure where the intensity and insonation mode were modified constantly throughout a treatment, limiting an evaluation from the perspective of ultrasonics. These implied that HIFU should be applied as an alternative at most occasions. The present clinical trials had defects making against the understating of HIFU.

scholarly journals The Use of High-Intensity Focused Ultrasound (HIFU) Plus 150mg Bicalutamide as First Line Salvage Therapy for Local Recurrent Prostate Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Jian-zhou Cao ◽  
Rui Su ◽  
Jin-feng Pan ◽  
Ze-jun Yan ◽  
Qi Ma
Keyword(s):  
Prostate Cancer ◽  
Salvage Therapy ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Local Tumor ◽  
First Line ◽  
Minimal Invasiveness ◽  
Tumor Load

Patients with localized prostate cancer (PCa) are often treated with radical prostatectomy (RP). However, more than 30% of such patients have high risk of recurrence. Salvage radiotherapy (SRT), androgen deprivation therapy (ADT) and combination of radiotherapy and ADT are the standard care for recurrent PCa. Recently, high intensity focused ultrasound (HIFU) has gradually applied in the treatment of recurrent PCa. Here, we proposed a hypothesis that combined HIFU and bicalutamide 150mg as first line salvage therapy to treat patients with local recurrent PCa with visible lesions due to the following advantages: (1) HIFU is effective in reducing local tumor load, and bicalutamide 150mg is a feasible and safety option to combine with HIFU. (2) Compared with radiotherapy, HIFU plus 150mg bicalutamide is minimal invasiveness with fewer adverse effects and better quality of life(QOL); (3) Radiotherapy can be preserved as the second-line salvage method in the cases who are failure to HIFU and 150mg bicalutamide combination. More clinical trials are warranted to confirm this hypothesis in treatment with recurrent PCa.

High intensity focused ultrasound for cyclocoagulation: From transducer design to early clinical trials.

2011 ◽  
Vol 129 (4) ◽  
pp. 2575-2575
Author(s):  
Cyril Lafon ◽  
Florent Aptel ◽  
Thomas Charrel ◽  
Alain Birer ◽  
Françoise Chavrier ◽  
...  
Keyword(s):  
Clinical Trials ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Transducer Design

scholarly journals Updates on MR-Guided Focused Ultrasound for Symptomatic Uterine Fibroids

2018 ◽  
Vol 35 (01) ◽  
pp. 017-022 ◽  
Author(s):  
Maureen Kohi ◽  
Divya Sridhar
Keyword(s):  
Magnetic Resonance ◽  
Patient Selection ◽  
High Intensity ◽  
Comparative Effectiveness ◽  
Focused Ultrasound ◽  
Uterine Fibroids ◽  
High Intensity Focused Ultrasound ◽  
Therapeutic Modality ◽  
Selection Technique

AbstractMagnetic-resonance–guided focused ultrasound (MRgFUS), also called high-intensity focused ultrasound (HIFU) is an effective, noninvasive uterine-preserving treatment for symptomatic uterine fibroids. As the use of this therapeutic modality is not yet widespread, it may remain unfamiliar to many interventional radiologists. The purpose of this review is to discuss MRgFUS, including technology, patient selection, technique, outcomes, complications, and recent data on fertility and comparative effectiveness.

scholarly journals High-Intensity Focused Ultrasound in Small Renal Masses

2008 ◽  
Vol 2008 ◽  
pp. 1-5
Author(s):  
Jose Rubio Briones ◽  
Argimiro Collado Serra ◽  
Alvaro Gómez-Ferrer Lozano ◽  
Juan Casanova Ramón-Borja ◽  
Inmaculada Iborra Juan ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Basic Research ◽  
Clinical Applications ◽  
High Intensity Focused Ultrasound ◽  
Small Renal Masses ◽  
Renal Masses ◽  
Therapeutic Results ◽  
Near Future

High-intensity focused ultrasound (HIFU) competes with radiofrequency and cryotherapy for the treatment of small renal masses as a third option among ablative approaches. As an emerging technique, its possible percutaneous or laparoscopic application, low discomfort to the patient and the absence of complications make this technology attractive for the management of small renal masses. This manuscript will focus on the principles, basic research and clinical applications of HIFU in small renal masses, reviewing the present literature. Therapeutic results are controversial and from an clinical view, HIFU must be considered a technique under investigation at present time. Further research is needed to settle its real indications in the management of small renal masses; maybe technical improvements will certainly facilitate its use in the management of small renal masses in the near future.

Role of High-Intensity Focused Ultrasound in Treatment of Hepatocellular Carcinoma

2011 ◽  
Vol 77 (11) ◽  
pp. 1496-1501 ◽  
Author(s):  
Hua-Ping Shen ◽  
Jian-Ping Gong ◽  
Guo-Qing Zuo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Future Development ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Clinical Applications ◽  
High Intensity Focused Ultrasound ◽  
Therapeutic Modality ◽  
Tumor Treatment ◽  
Advanced Stages

About 70 per cent of patients with hepatocellular carcinoma are diagnosed at intermediate or advanced stages, and most of them are technically unresectable. As a novel, emerging therapeutic modality, high intensity focused ultrasound (HIFU) has a great potential for tumor treatment. In this review, principle of HIFU technique is introduced, and an overview of clinical applications and limitations of HIFU for HCC treatment, as well as prospects for future development, is provided. Consequently, HIFU has been considered a safe and feasible procedure for HCC treatment.

260: High Intensity Focused Ultrasound Combined with Endocrine Therapy in Treating High or Intermediate Risk Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 86-86
Author(s):  
Makoto Sumitomo ◽  
Junichi Asakuma ◽  
Yasumasa Hanawa ◽  
Kazuhiko Nagakura ◽  
Masamichi Hayakawa
Keyword(s):  
Prostate Cancer ◽  
Endocrine Therapy ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Intermediate Risk ◽  
Risk Prostate Cancer

1400: Early Clinical Experience Using High-Intensity Focused Ultrasound for the Treatment of Renal Tumours

2005 ◽  
Vol 173 (4S) ◽  
pp. 379-380
Author(s):  
James E. Kennedy ◽  
Rowland O. Illing ◽  
Feng Wu ◽  
Gail R. ter Haar ◽  
Rachel R. Phillips ◽  
...  
Keyword(s):  
Clinical Experience ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Early Clinical Experience ◽  
Renal Tumours
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