scholarly journals The effects of periparturient administration of flunixin meglumine on the health and production of dairy cattle

2017 ◽  
Vol 100 (1) ◽  
pp. 582-587 ◽  
Author(s):  
N.C. Newby ◽  
K.E. Leslie ◽  
H.D.Putnam Dingwell ◽  
D.F. Kelton ◽  
D.M. Weary ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Flunixin Meglumine

scholarly journals Effect of flunixin meglumine and carprofen on pregnancy rates in dairy cattle

2010 ◽  
Vol 93 (11) ◽  
pp. 5140-5146 ◽  
Author(s):  
X. von Krueger ◽  
W. Heuwieser
Keyword(s):  
Dairy Cattle ◽  
Pregnancy Rates ◽  
Flunixin Meglumine

Effect of flunixin meglumine on placental expulsion in dairy cattle after a caesarean

1999 ◽  
Vol 144 (25) ◽  
pp. 702-703 ◽  
Author(s):  
R. O. Waelchli ◽  
R. Thun ◽  
H. Stocker
Keyword(s):  
Dairy Cattle ◽  
Flunixin Meglumine

scholarly journals Effects of transdermal flunixin meglumine on experimentally induced lameness in adult dairy cattle

2019 ◽  
Vol 102 (7) ◽  
pp. 6418-6430 ◽  
Author(s):  
M.D. Kleinhenz ◽  
P.J. Gorden ◽  
J.S. Smith ◽  
J.A. Schleining ◽  
K.E. Kleinhenz ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Flunixin Meglumine ◽  
Experimentally Induced

scholarly journals PSI-4 Comparison of analgesics for control of lameness-associated pain in lactating dairy cattle

2019 ◽  
Vol 97 (Supplement_2) ◽  
pp. 162-163
Author(s):  
Rochelle Warner ◽  
Michael Kleinhenz ◽  
Joshua Ydstie ◽  
Jennifer Schleining ◽  
Larry Wulf ◽  
...  
Keyword(s):  
Pain Management ◽  
Dairy Cattle ◽  
Amphotericin B ◽  
Controlled Trial ◽  
Dairy Industry ◽  
The United States ◽  
Positive Control ◽  
Flunixin Meglumine ◽  
The Impact ◽  
Lactating Dairy Cattle

Abstract Both the economic loss and welfare implications of lameness vastly impact the dairy industry. There is a need for effective modalities of analgesia to minimize welfare concerns regarding lameness associated pain in lactating dairy cattle. To date, there are no labeled products with pain control indications available for lactating dairy cattle in the United States. Non-steroidal anti-inflammatory drugs (NSAIDs), like meloxicam and flunixin meglumine, are commonly used by veterinarians for pain management. Data is limited as to their efficacy in lameness-associated pain management. The overarching goal of this study was to compare the analgesic effects of flunixin meglumine (IV) and meloxicam (PO) in lactating dairy cattle with experimentally induced lameness via intra-articular injection of amphotericin B. We hypothesized that lameness would improve under meloxicam treatment compared to flunixin meglumine or no treatment control. A double blinded, randomized controlled trial involving positive and negative controls created the framework to assess efficacy parameters. Parameters included pressure algometry, pressure mat analysis, lameness score, infrared thermography imaging, substance P, and cortisol concentrations of 48 lactating Holstein cows across a six-day time period. Intra-articular injection with amphotericin B resulted in mild transient lameness. Results indicated statistically significant treatment by time effects for several parameters. Visual lameness scores showed flunixin meglumine was equally effective to meloxicam and both more effective than the positive control (P < 0.0001). Flunixin meglumine administered animals displayed lower cortisol levels to that of meloxicam treated cows and both more effective than the positive control (P = 0.0008). The cows treated with meloxicam withstood a greater force created by mechanical nociception threshold than cows administered flunixin meglumine and both more effective than the positive control (P = 0.0008). The impact of NSAID use as a therapeutic treatment of lameness is insurmountable in combatting welfare concerns in the dairy industry.

Effects of a single injection of Flunixin meglumine or Carprofen postpartum on haematological parameters, productive performance and fertility of dairy cattle

2018 ◽  
Vol 58 (2) ◽  
pp. 322 ◽  
Author(s):  
M. Giammarco ◽  
I. Fusaro ◽  
G. Vignola ◽  
A. C. Manetta ◽  
A. Gramenzi ◽  
...  
Keyword(s):  
Heart Rate ◽  
Dairy Cattle ◽  
Body Condition ◽  
Rectal Temperature ◽  
Body Condition Score ◽  
Single Injection ◽  
Sampling Time ◽  
Productive Performance ◽  
Flunixin Meglumine ◽  
Condition Score

The objective of the present research was to evaluate the effects of a single injection of Flunixin meglumine (FM) or Carprofen postpartum on haematological indicators, productive performance and fertility of Italian Friesian dairy cattle. In total, 60 cows, including 42 multiparous and 18 primiparous, were assigned to one of the following three treatments: (1) FM (2.2 mg i.m./kg of bodyweight (BW); Meflosyl 50 mg/mL), (2) Carprofen (CA; 1.4 mg s.c./kg of BW; Rymadil 50 mg/mL) or (3) saline (control) at 2.0 mL s.c./45.5 kg of BW. All treatments were administrated by a single injection within 12 h after calving. Individual milk yield was daily recorded during the trial and composition was determined at 7, 14, 21, 28, 35 and 60 days in milk (DIM). BWs were recorded at –21 ± 5 days before calving, and 1, 7, 14, 21, 28, 35 and 60 days after calving before the morning milking. Individual blood samples were collected from each animal for haemato-biochemical evaluation 3 weeks before calving (T0) and then repeated at the following times: within 12 h after calving, immediately before the administration of the anti-inflammatory drug (FM or CA; T1), ~36 h after calving (T2), 4 days after calving (T3) and 11 days after calving (T4). At each sampling time, the rectal temperature and the heart rate were monitored. Body condition score was determined after each sampling time and at 35 and 60 DIM. FM and CA treatments did not influence rectal temperature and heart rate during the first 11 DIM; no differences in overall milk yield, milk composition and dry matter intake were found. BW and body condition score were not affected by treatments throughout the study. Treatments did not affect serum metabolite concentrations of glucose, non-esterified fatty acids, β-hydroxybutyrate, serum urea nitrogen, total protein and albumin. Control cows showed a higher culling rate (P < 0.05) than did the FM- and CA-treated cows (25% vs 15% vs 5% respectively). FM-treated multiparous cows had a significantly (P < 0.05) lower incidence of retained placenta than did control and CA-treated cows (2.3% vs 9.3% vs 14% respectively). Furthermore, a greater percentage of cows pregnant (35% vs 10%) at the first insemination (P < 0.001) in non-steroidal anti-inflammatory drug groups than in control was found. Our findings evidenced that a single injection of FM or CA to non-febrile cows immediately after parturition could positively affect the metabolic adaptation of the cows at the onset of lactation and this aspect can positively influence reproductive performances and the culling rate.

21 Evaluation of Transdermal Flunixin Meglumine on Experimentally Induced Lameness in Adult Dairy Cattle.

2018 ◽  
Vol 96 (suppl_2) ◽  
pp. 11-11
Author(s):  
M D Kleinhenz ◽  
P J Gorden ◽  
J Smith ◽  
J A Schleining ◽  
K E Kleinhenz ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Flunixin Meglumine ◽  
Experimentally Induced

Effects of Retinoic Acid and 1,25-Dihydroxyvitamin D3 on IFN-gamma Secretion by Mononuclear Leukocytes from Nulliparous and Postparturient Dairy Cattle

2000 ◽  
Vol 70 (3) ◽  
pp. 92-101 ◽  
Author(s):  
Burim Ametaj ◽  
Brian Nonnecke ◽  
Ronald Horst ◽  
Donald Beitz
Keyword(s):  
Retinoic Acid ◽  
Dairy Cattle ◽  
Dairy Cows ◽  
Dairy Cow ◽  
Pokeweed Mitogen ◽  
Mononuclear Leukocytes ◽  
Combined Effects ◽  
Ifn Gamma ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D

Individual and combined effects of several isomers of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on interferon-gamma (IFN-gamma) secretion by blood mononuclear leukocytes (MNL) from nulliparous and postparturient Holstein cattle were evaluated in vitro. In the first experiment, effects on incubation period (24 to 72 hours) and time of supplementation (0 to 32 hours) with all-trans, 9-cis, 13-cis-, and 9,13-dicis-RAs (0 to 100 nM) on IFN-gamma secretion by pokeweed mitogen (PWM)-stimulated (0 and 10 mug/ml) MNL from nulliparous cattle were evaluated. In the second experiment, MNL from postparturient cows (bled at 0, 2, 4, and 16 days postpartum) were stimulated with PWM (0 and 10 mug/ml) in the presence of RA isomers (9-cis- or 9,13-dicis-RA; 0 to 100 nM), 1,25-(OH)2D3 (0 to 100 nM), or with combinations of these metabolites. The results show that individual isomers of RA had no effect on IFN-gamma secretion by PWM-stimulated MNL from nulliparous or postparturient cows. Furthermore 1,25-dihydroxyvitamin D3 inhibited IFN-gamma secretion by MNL from nulliparous and postparturient dairy cows; however, the degree of inhibition was greater when 9-cis- and 9,13-dicis-RA were also present in the cultures. Finally mononuclear leukocytes from postparturient dairy cows produced substantially less IFN-gamma than did MNL from nulliparous cattle. It is concluded that retinoic acids individually did not affect the capacity of leukocytes from dairy cattle to secrete IFN-gamma. This result is in marked contrast to studies in monogastric species indicating that RAs inhibit IFN-gamma secretion by peripheral blood T cells. Inhibition of IFN-gamma secretion by 1,25-(OH)2D3 was potentiated by 9-cis- and 9,13-di-cis-retinoics acids, suggesting that an excess of dietary vitamins A and D may compromise further the naturally immunosuppressed postparturient dairy cow. Additional research is necessary to determine if the combined effects of these metabolites on IFN-gamma secretion represent an increased susceptibility of the dairy cow to infectious diseases during the periparturient period. Lower secretion of IFN-gamma by MNL from postpartutient dairy cows, relative to nulliparous cattle, suggests that recently-calved cows are naturally immunosuppressed.

Aloe vera for disinfection of teats in dairy cattle

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
F Correia Shimamoto ◽  
P Falbo ◽  
L Sussumu Matsumoto ◽  
M Alves da Silva ◽  
RM Gonçalves da Silva ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Aloe Vera
Sign in / Sign up

Export Citation Format

Share Document