scholarly journals Effect of enterotoxigenic Escherichia coli vaccine on innate immune function of bovine mammary gland infused with lipopolysaccharide

2012 ◽  
Vol 95 (9) ◽  
pp. 5067-5074 ◽  
Author(s):  
K. Morimoto ◽  
N. Kanda ◽  
S. Shinde ◽  
N. Isobe
Keyword(s):  
Escherichia Coli ◽  
Mammary Gland ◽  
Immune Function ◽  
Innate Immune ◽  
Enterotoxigenic Escherichia Coli ◽  
Bovine Mammary Gland ◽  
Innate Immune Function

scholarly journals Early Life Ozone Exposure Results in Dysregulated Innate Immune Function and Altered microRNA Expression in Airway Epithelium

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90401 ◽  
Author(s):  
Candice C. Clay ◽  
Kinjal Maniar-Hew ◽  
Joan E. Gerriets ◽  
Theodore T. Wang ◽  
Edward M. Postlethwait ◽  
...  
Keyword(s):  
Immune Function ◽  
Airway Epithelium ◽  
Early Life ◽  
Microrna Expression ◽  
Innate Immune ◽  
Ozone Exposure ◽  
Innate Immune Function

scholarly journals Influence of Crohn’s disease related polymorphisms in innate immune function on ileal microbiome

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0213108 ◽  
Author(s):  
Ellen Li ◽  
Yuanhao Zhang ◽  
Xinyu Tian ◽  
Xuefeng Wang ◽  
Grace Gathungu ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Immune Function ◽  
Innate Immune ◽  
Innate Immune Function

scholarly journals Enterotoxigenic Escherichia coli Prevents Host NF-κB Activation by Targeting IκBα Polyubiquitination

2012 ◽  
Vol 80 (12) ◽  
pp. 4417-4425 ◽  
Author(s):  
Xiaogang Wang ◽  
Philip R. Hardwidge
Keyword(s):  
Escherichia Coli ◽  
Immune Responses ◽  
Diarrheal Disease ◽  
Innate Immune ◽  
Host Cells ◽  
Enterotoxigenic Escherichia Coli ◽  
Host Responses ◽  
Innate Immune Responses ◽  
Content Type ◽  
Heat Stable

ABSTRACTThe NF-κB pathway regulates innate immune responses to infection. NF-κB is activated after pathogen-associated molecular patterns are detected, leading to the induction of proinflammatory host responses. As a countermeasure, bacterial pathogens have evolved mechanisms to subvert NF-κB signaling. EnterotoxigenicEscherichia coli(ETEC) causes diarrheal disease and significant morbidity and mortality for humans in developing nations. The extent to which this important pathogen subverts innate immune responses by directly targeting the NF-κB pathway is an understudied topic. Here we report that ETEC secretes a heat-stable, proteinaceous factor that blocks NF-κB signaling normally induced by tumor necrosis factor (TNF), interleukin-1β, and flagellin. Pretreating intestinal epithelial cells with ETEC supernatant significantly blocked the degradation of the NF-κB inhibitor IκBα without affecting IκBα phosphorylation. Data from immunoprecipitation experiments suggest that the ETEC factor functions by preventing IκBα polyubiquitination. Inhibiting clathrin function blocked the activity of the secreted ETEC factor, suggesting that this yet-uncharacterized activity may utilize clathrin-dependent endocytosis to enter host cells. These data suggest that ETEC evades the host innate immune response by directly modulating NF-κB signaling.

scholarly journals Markers of Innate Immune Function Are Associated with Vitamin A Stores in Men

2008 ◽  
Vol 139 (2) ◽  
pp. 377-385 ◽  
Author(s):  
Shaikh M. Ahmad ◽  
Marjorie J. Haskell ◽  
Rubhana Raqib ◽  
Charles B. Stephensen
Keyword(s):  
Vitamin A ◽  
Immune Function ◽  
Innate Immune ◽  
Innate Immune Function
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