scholarly journals Association between milk protein gene variants and protein composition traits in dairy cattle

2012 ◽  
Vol 95 (1) ◽  
pp. 440-449 ◽  
Author(s):  
W. Huang ◽  
F. Peñagaricano ◽  
K.R. Ahmad ◽  
J.A. Lucey ◽  
K.A. Weigel ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Milk Protein ◽  
Protein Gene ◽  
Protein Composition ◽  
Gene Variants ◽  
Milk Protein Gene

scholarly journals Growth hormone and milk protein gene polymorphism in relation to the levels of some hormones, enzymes and metabolites in growing dairy cattle

1999 ◽  
Vol 39 (1) ◽  
pp. 96-97
Author(s):  
J. Oprzadek ◽  
L. Zwierzchowski ◽  
M. Lukaszewicz ◽  
E. Dymnick ◽  
Z. Reklewski ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gene Polymorphism ◽  
Dairy Cattle ◽  
Milk Protein ◽  
Protein Gene ◽  
Milk Protein Gene

scholarly journals Pattern of Expression of the Uterine Milk Protein Gene and its Association with Productive Life in Dairy Cattle

2007 ◽  
Vol 90 (5) ◽  
pp. 2427-2433 ◽  
Author(s):  
H. Khatib ◽  
V. Schutzkus ◽  
Y.M. Chang ◽  
G.J.M. Rosa
Keyword(s):  
Dairy Cattle ◽  
Milk Protein ◽  
Protein Gene ◽  
Milk Protein Gene ◽  
Productive Life

DNA-based identification of novel ovine milk protein gene variants

2014 ◽  
Vol 121 (2-3) ◽  
pp. 225-231 ◽  
Author(s):  
Julia L. Tetens ◽  
Cord Drögemüller ◽  
Georg Thaller ◽  
Jens Tetens
Keyword(s):  
Milk Protein ◽  
Protein Gene ◽  
Gene Variants ◽  
Milk Protein Gene

scholarly journals Variations in the Regulatory Region of Alpha S1-Casein Milk Protein Gene among Tropically Adapted Indian Native (Bos Indicus) Cattle

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Amit Kishore ◽  
Manishi Mukesh ◽  
Ranbir C. Sobti ◽  
Bishnu P. Mishra ◽  
Monika Sodhi
Keyword(s):  
Binding Sites ◽  
Milk Protein ◽  
Protein Gene ◽  
Bos Indicus ◽  
Regulatory Region ◽  
Protein Composition ◽  
Nucleotide Substitutions ◽  
Milk Protein Gene ◽  
Regulatory Domains ◽  
Indian Cattle

Regulatory region of milk protein alpha S1-casein (αS1-CN) gene was sequenced, characterized, and analyzed to detect variations among 13 Indian cattle (Bos indicus) breeds. Comparative analysis of 1,587 bp region comprising promoter (1,418 bp), exon-I (53 bp), and partial intron-I (116 bp) revealed 35 nucleotide substitutions (32 within promoter region, 1 in exon-I, and 2 in partial intron-I region) and 4 Indels. Within promoter, 15 variations at positions −1399 (A > G), −1288 (G > A), −1259 (T > C), −1158 (T > C), −1016 (A > T), −941 (T > G), −778 (C > T), −610 (G > A), −536 (A > G), −521 (A > G), −330 (A > C), −214 (A > G), −205 (A > T), −206 (C > A), and −175 (A > G) were located within the potential transcription factor binding sites (TFBSs), namely, NF-κE1/c-Myc, GATA-1, GATA-1/NF-E, Oct-1/POU3F2, MEF-2/YY1, GATA-1, AP-1, POU1F1a/GR, TMF, GAL4, YY1/Oct-1, HNF-1, GRalpha/AR, GRalpha/AR, and AP-1, respectively. Seventy-four percent (26/35) of the observed SNPs were novel to Indian cattle and 11 of these novel SNPs were located within one or more TFBSs. Collectively, these might influence the binding affinity towards their respective nuclear TFs thus modulating the level of transcripts in milk and affecting overall protein composition. The study provides information on several distinct variations across indicine and taurine αS1-CN regulatory domains.

scholarly journals Nuclear Factor 1-C2 Contributes to the Tissue-specific Activation of a Milk Protein Gene in the Differentiating Mammary Gland

2002 ◽  
Vol 277 (20) ◽  
pp. 17589-17596 ◽  
Author(s):  
Marie Kannius-Janson ◽  
Eva M. Johansson ◽  
Gunnar Bjursell ◽  
Jeanette Nilsson
Keyword(s):  
Mammary Gland ◽  
Milk Protein ◽  
Protein Gene ◽  
Nuclear Factor ◽  
Milk Protein Gene ◽  
Tissue Specific ◽  
Nuclear Factor 1

Hormone-dependent milk protein gene expression in bovine mammary explants from biopsies at different stages of pregnancy

2004 ◽  
Vol 71 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Paul A Sheehy ◽  
James J Della-Vedova ◽  
Kevin R Nicholas ◽  
Peter C Wynn
Keyword(s):  
Gene Expression ◽  
Milk Protein ◽  
Protein Gene ◽  
Bovine Milk ◽  
Mammary Tissue ◽  
Endocrine Regulation ◽  
Surgical Biopsy ◽  
Milk Protein Gene ◽  
Milk Protein Gene Expression

A method for the collection of mammary biopsies developed previously was refined and used to study the endocrine regulation of bovine milk protein gene expression. Our surgical biopsy method used real-time ultrasound imaging and epidural analgesia to enable recovery of a sufficient quantity of mammary tissue from late-pregnant dairy cows for explant culture in vitro. The time of biopsy was critical for prolactin-dependent induction of milk protein gene expression in mammary explants, as only mammary tissue from cows nearing 30 d prepartum was hormone-responsive. This suggests that during the later stages of pregnancy a change in the responsiveness of milk protein gene expression to endocrine stimuli occurred in preparation for lactation. This may relate to the diminution of a putative population of undifferentiated cells that were still responsive to prolactin. Alternatively, the metabolic activity of the tissue had increased to the level whereby the response of the tissue was no longer assessable using this model in vitro.

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