scholarly journals Citrus phytochemicals and their potential effects on the prevention and treatment of obesity: review and progress of the past 10 years

2018 ◽  
Vol 4 ◽  
Author(s):  
Shi Feng ◽  
Yu Wang
Keyword(s):  
Citrus Fruits ◽  
Active Components ◽  
Safety Assurance ◽  
The Past ◽  
The World ◽  
Prevention And Treatment ◽  
Life Threatening ◽  
Treatment Of Obesity ◽  
Obesity Drugs

Obesity is a chronic life-threatening disease throughout the world. Available anti-obesity drugs may have hazardous side effects and no long-term safety assurance is in place for patients. In recent decades, alternative natural therapeutics have been intensively investigated. Among them, phytochemicals from citrus fruits have shown tremendous potential to combat obesity through different mechanisms. To date, the most active biological constitutes identified in citrus fruits are flavonoids and p-synephrine. These exert anti-obesity effects through multiple mechanisms, including regulating energy intake and expenditure, regulating lipid metabolism and regulating adipogenesis. In this mini review, a survey focusing on citrus phytochemicals and their anti-obesity activities is presented, together with an update of findings over the last 10 years, including active components and mechanisms of anti-obesity activities.

scholarly journals Virus Eradication and Synthetic Biology: Changes with SARS-CoV-2?

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 569
Author(s):  
Jean-Nicolas Tournier ◽  
Joseph Kononchik
Keyword(s):  
Clinical Trials ◽  
Synthetic Biology ◽  
Viral Disease ◽  
Virus Eradication ◽  
Disease Eradication ◽  
The Public ◽  
The Past ◽  
The World ◽  
Significant Effort

The eradication of infectious diseases has been achieved only once in history, in 1980, with smallpox. Since 1988, significant effort has been made to eliminate poliomyelitis viruses, but eradication is still just out of reach. As the goal of viral disease eradication approaches, the ability to recreate historically eradicated viruses using synthetic biology has the potential to jeopardize the long-term sustainability of eradication. However, the emergence of the severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 pandemic has highlighted our ability to swiftly and resolutely respond to a potential outbreak. This virus has been synthetized faster than any other in the past and is resulting in vaccines before most attenuated candidates reach clinical trials. Here, synthetic biology has the opportunity to demonstrate its truest potential to the public and solidify a footing in the world of vaccines.

scholarly journals Acute graft-versus-host disease: a bench-to-bedside update

Blood ◽  
2014 ◽  
Vol 124 (3) ◽  
pp. 363-373 ◽  
Author(s):  
Shernan G. Holtan ◽  
Marcelo Pasquini ◽  
Daniel J. Weisdorf
Keyword(s):  
Small Molecules ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Multiple Modalities ◽  
Graft Versus Host ◽  
The Past ◽  
Prevention And Treatment ◽  
Near Future ◽  
Acute Graft

Abstract Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have already reached the clinic are prophylaxis strategies based upon a refinement of our understanding of key sensors, effectors, suppressors of the immune alloreactive response, and the resultant tissue damage from the aGVHD inflammatory cascade. In the near future, aGVHD prevention and treatment will likely involve multiple modalities, including small molecules regulating immunologic checkpoints, enhancement of suppressor cytokines and cellular subsets, modulation of the microbiota, graft manipulation, and other donor-based prophylaxis strategies. Despite long-term efforts, major challenges in treatment of established aGVHD still remain. Resolution of inflammation and facilitation of rapid immune reconstitution in those with only a limited response to corticosteroids is a research arena that remains rife with opportunity and urgent clinical need.

scholarly journals Understanding Urban Growth in Beijing-Tianjin-Hebei Region over the Past 100 Years Using Old Maps and Landsat Data

2021 ◽  
Vol 13 (16) ◽  
pp. 3264 ◽  
Author(s):  
Shuang Li ◽  
Zhongqiu Sun ◽  
Yafei Wang ◽  
Yuxia Wang
Keyword(s):  
Remote Sensing ◽  
Urban Area ◽  
Spatial Data ◽  
Urban Expansion ◽  
Remote Sensing Images ◽  
The Past ◽  
Old Maps ◽  
The World ◽  
The City

Studying urban expansion from a longer-term perspective is of great significance to obtain an in-depth understanding of the process of urbanization. Remote sensing data are mostly selected to investigate the long-term expansion of cities. In this study, we selected the world-class urban agglomeration of Beijing-Tianjin-Hebei (BTH) as the study area, and then discussed how to make full use of multi-source, multi-category, and multi-temporal spatial data (old maps and remote sensing images) to study long-term urbanization. Through this study, we addressed three questions: (1) How much has the urban area in BTH expanded in the past 100 years? (2) How did the urban area expand in the past century? (3) What factors or important historical events have changed the development of cities with different functions? By comprehensively using urban spatial data, such as old maps and remote sensing images, geo-referencing them, and extracting built-up area information, a long-term series of urban built-up areas in the BTH region can be obtained. Results show the following: (1) There was clear evidence of dramatic urban expansion in this area, and the total built-up area had increased by 55.585 times, from 126.181 km2 to 7013.832 km2. (2) Continuous outward expansion has always been the main trend, while the compactness of the built-up land within the city is constantly decreasing and the complexity of the city boundary is increasing. (3) Cities in BTH were mostly formed through the construction of city walls during the Ming and Qing dynasties, and the expansion process was mostly highly related to important political events, traffic development, and other factors. In summary, the BTH area, similarly to China and most regions of the world, has experienced rapid urbanization and the history of such ancient cities should be further preserved with the combined use of old maps.

Why blackseed can be the cure for all illnesses except death

2021 ◽  
Vol 9 (4) ◽  
pp. 75-80
Author(s):  
Rashid Bhikha ◽  
Keyword(s):  
Pharmacological Action ◽  
The Body ◽  
Past Century ◽  
Self Healing ◽  
The Past ◽  
The Bible ◽  
The World ◽  
Prevention And Treatment ◽  
Vast Range ◽  
Regular Intake

The use of plants to prevent and treat illnesses has been known since time immemorial. Blackseed has been used in different civilizations around the world for centuries. The curative properties of blackseed were mentioned in the Bible and further elaborated on by Prophet Mohammed (PBUH) as “Hold on to the use of blackseed, as it has a remedy for every illness except death”. Extensive research conducted over the past century into the phytochemistry of blackseed has identified many active ingredients and confirmed its pharmacological action in the treatment of a vast range of illness conditions across the different systems of the body, including the prevention and treatment of cancer, and optimum functioning of the immune system. Furthermore, the Tibb philosophical principles highlight the ability of the body’s inherent self-healing capacity, known as Physis, and the intricate functioning of the human body, based on the temperamental and humoral theory. This paper emphasizes the importance of Physis, and its role in the maintenance and restoration of health with the regular intake of blackseed, highlighting why blackseed can be a cure for all illnesses except death. Keywords: Blackseed, phytochemistry, pharmacological action, Tibb philosophical principles.

Pressing problems of the euro zone — And beyond (OR: What may break the camel’s back)

2012 ◽  
Vol 62 (4) ◽  
pp. 423-434
Author(s):  
Jan Winiecki
Keyword(s):  
Monetary Union ◽  
Present Writer ◽  
Large Majority ◽  
Short Term ◽  
Large Measure ◽  
Euro Zone ◽  
The Past ◽  
The World ◽  
Simple Question

A look at the Western debate about West’s problems reveals what the present writer regards in a large measure as an irritating superficiality. Nowhere is it better visible than in the mainstream discussions about the euro zone and its problems, where most debaters glide over the fundamentals of Europe’s long-term problems and concentrate on the superficial and short-term issues. The discussions on how to “save” the euro zone strangely forget the defects in its creation, glide over the lessons to be drawn from policies pursued during the past decade, and defend the virtue of maintaining its present membership. But the problems of Europe run much deeper than the survival or collapse of the monetary union. Even if we assume that the problems of confidence the member states have in each other’s behaviour are restored and the rest of the world regains confidence in the institutions of the monetary union, the fundamental problems will remain unsolved. A clue to the real long-term problems may be found in the answer to a rather simple question. It runs as follows: “Why is the large majority of European countries indebted to such an extent that any further increase in debt to GDP ratio generates panic reactions among potential lenders?”

scholarly journals Anticancer Herbs for Improving the Quality of Life

2018 ◽  
Vol 5 (1) ◽  
pp. 1-11
Author(s):  
Darakhshan Qaiser ◽  
Anurag Srivastava ◽  
Afshan Qaiser
Keyword(s):  
Animal Studies ◽  
Health Benefit ◽  
Developed Countries ◽  
Active Components ◽  
Public Health Burden ◽  
Health Burden ◽  
The World ◽  
Prevention And Treatment ◽  
Developing And Developed Countries

In the world, there are many systems of traditional medicine. Cancer is the major public health burden both in developing and developed countries. Around 50% of existing medicines for cancer treatment have plants origin. Anticancer property of some plant extracts proven to be significantly effective in the treatment of cancer. Many herbs like sadabahar, turmeric, Kalonji, cannabis, garlic, flaxseed contain active components which may be effective in prevention and treatment of many cancers. The present review focuses on the evidence of health benefit of various herbs though recent human and animal studies.

scholarly journals Rural Poverty and Land Degradation: A Review of the Current State of Knowledge

1998 ◽  
Vol 37 (4II) ◽  
pp. 1053-1070 ◽  
Author(s):  
Sohail Jehangir Malik ◽  
Hina Nazli
Keyword(s):  
World Bank ◽  
Land Degradation ◽  
Rural Poverty ◽  
The Past ◽  
Current State ◽  
The World Bank ◽  
Resource Degradation ◽  
The World ◽  
Short And Long Term

By highlighting the lack of rigorous evidence and calling for a greater understanding of the interaction of the two processes, a recent study [Nelson et al. (1997)] has called into question the strong perception that poverty is both a consequence as well as a cause of resource degradation.1 This perception which is widely held is strongly evident in the writings of the multilateral development agencies such as the World Bank (1990) and IFAD (1992) and exists despite extensive reviews which indicate that the short- and long-term implications of land degradation are not very clear [see Scherr and Yadav (1995)]. Similarly, while knowledge about poverty is expanding rapidly, thanks in large parts to the massive international focus and resources brought to bear on its understanding in the past ten.........................

scholarly journals Trying to Survive A Serious Heart Condition in Time of COVID-19

2021 ◽  
Vol 24 (2) ◽  
pp. E372-E374
Author(s):  
Josip Varvodic ◽  
Verica Mikecin ◽  
Irzal Hadzibegovic ◽  
Marko Kutlesa ◽  
Carla Coric ◽  
...  
Keyword(s):  
Heart Failure ◽  
Infective Endocarditis ◽  
Aortic Root ◽  
The Past ◽  
Cardiac Decompensation ◽  
The World ◽  
Life Threatening ◽  
Emergent Surgery ◽  
Large Abscess ◽  
Heart Condition

The world has suffered over the past year under COVID-19. Unfortunately, people still are getting sick from other, also severe, diseases. Although the COVID-19 infection is present, patients need treatment for other life-threatening conditions. We present the case of a 36-year-old patient with severe infective endocarditis with a large abscess of the aortic root, who also is COVID-19 positive. Definitive diagnostics and treatment were avoided due to COVID-19 infection. In the end, emergent surgery was indicated due to acute cardiac decompensation and the development of heart failure symptoms, and the patient recovered uneventfully after surgery.

scholarly journals Neuroimaging of Sex/Gender Differences in Obesity: A Review of Structure, Function, and Neurotransmission

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1942
Author(s):  
Danielle S. Kroll ◽  
Dana E. Feldman ◽  
Catherine L. Biesecker ◽  
Katherine L. McPherson ◽  
Peter Manza ◽  
...  
Keyword(s):  
Gender Differences ◽  
Structure Function ◽  
Behavioral Differences ◽  
Men And Women ◽  
The Past ◽  
Tailored Interventions ◽  
Prevention And Treatment ◽  
Prevalence Of Obesity ◽  
Treatment Of Obesity ◽  
The Brain

While the global prevalence of obesity has risen among both men and women over the past 40 years, obesity has consistently been more prevalent among women relative to men. Neuroimaging studies have highlighted several potential mechanisms underlying an individual’s propensity to become obese, including sex/gender differences. Obesity has been associated with structural, functional, and chemical alterations throughout the brain. Whereas changes in somatosensory regions appear to be associated with obesity in men, reward regions appear to have greater involvement in obesity among women than men. Sex/gender differences have also been observed in the neural response to taste among people with obesity. A more thorough understanding of these neural and behavioral differences will allow for more tailored interventions, including diet suggestions, for the prevention and treatment of obesity.

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