scholarly journals Possible Role of Bone γ-Carboxyglutamic Acid-Containing Protein in the Pathogenesis of Vitamin K Deficiency in Early Infancy

1987 ◽  
Vol 2 (3) ◽  
pp. 217-231
Author(s):  
Muneyoshi YOSHINAGA ◽  
Yoshiro TSUJI ◽  
Chiharu TSUTSUMI ◽  
Sachiko MORIUCHI
Keyword(s):  
Vitamin K ◽  
Early Infancy ◽  
Vitamin K Deficiency ◽  
Carboxyglutamic Acid ◽  
K Deficiency

scholarly journals Vitamin K in COVID-19—Potential Anti-COVID-19 Properties of Fermented Milk Fortified with Bee Honey as a Natural Source of Vitamin K and Probiotics

Fermentation ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 202
Author(s):  
Amira Mohammed Ali ◽  
Hiroshi Kunugi ◽  
Hend A. Abdelmageed ◽  
Ahmed S. Mandour ◽  
Mostafa Elsayed Ahmed ◽  
...  
Keyword(s):  
Vitamin K ◽  
Vitamin K Antagonists ◽  
Oral Anticoagulants ◽  
Empirical Studies ◽  
Fermented Milk ◽  
Organ Damage ◽  
Natural Source ◽  
Vitamin K Deficiency ◽  
K Deficiency

Vitamin K deficiency is evident in severe and fatal COVID-19 patients. It is associated with the cytokine storm, thrombotic complications, multiple organ damage, and high mortality, suggesting a key role of vitamin K in the pathology of COVID-19. To support this view, we summarized findings reported from machine learning studies, molecular simulation, and human studies on the association between vitamin K and SARS-CoV-2. We also investigated the literature for the association between vitamin K antagonists (VKA) and the prognosis of COVID-19. In addition, we speculated that fermented milk fortified with bee honey as a natural source of vitamin K and probiotics may protect against COVID-19 and its severity. The results reported by several studies emphasize vitamin K deficiency in COVID-19 and related complications. However, the literature on the role of VKA and other oral anticoagulants in COVID-19 is controversial: some studies report reductions in (intensive care unit admission, mechanical ventilation, and mortality), others report no effect on mortality, while some studies report higher mortality among patients on chronic oral anticoagulants, including VKA. Supplementing fermented milk with honey increases milk peptides, bacterial vitamin K production, and compounds that act as potent antioxidants: phenols, sulforaphane, and metabolites of lactobacilli. Lactobacilli are probiotic bacteria that are suggested to interfere with various aspects of COVID-19 infection ranging from receptor binding to metabolic pathways involved in disease prognosis. Thus, fermented milk that contains natural honey may be a dietary manipulation capable of correcting nutritional and immune deficiencies that predispose to and aggravate COVID-19. Empirical studies are warranted to investigate the benefits of these compounds.

scholarly journals PREVENTION OF BLEEDING ASSOCIATED WITH LATE VITAMIN K DEFICIENCY IN INFANTS OF THE FIRST THREE MONTHS OF LIFE - TACTICS OF REDUCTION OF DEATHS AND DISABILITY

2020 ◽  
pp. 52-60
Author(s):  
M. M. Kiselovа
Keyword(s):  
Vitamin K ◽  
The United States ◽  
Hemorrhagic Disease ◽  
Vitamin K Deficiency ◽  
Chronic Cholestasis ◽  
K Deficiency ◽  
Prophylactic Use ◽  
Role Of Parents ◽  
Current Guidelines

The article, intended for neonatologists, general practitioners, family medicine, pediatricians, presents the main causes of disorders in the hemostasis system, which lead to the development of hemorrhagic syndrome in newborns and infants. Emphasis is placed on various forms of neonatal hemorrhagic disease (NHD), which is based on a deficiency of fat-soluble vitamin K. The main risk group for bleeding associated with late vitamin K deficiency is formed by children who are exclusively breastfed. The article presents modern approaches to the prevention of late bleeding associated with vitamin K deficiency, which is based on chronic problems of the digestive system – chronic cholestasis, cystic fibrosis and others. Describes and interprets current guidelines for the prophylactic use of vitamin K in infants in the first three months of life in European countries of high economic development, the United States, which reflects various effective schemes for the prevention of bleeding associated with vitamin K deficiency in infants, differing in single dose application of a preventive course and a way of administration of vitamin K (phytomenadione). The role of parents in the prevention of vitamin K deficiency in infants who are breastfed is emphasized.

Emerging Issues in Vitamin K Research

2011 ◽  
Vol 16 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Jennifer T. Truong ◽  
Sarah L. Booth
Keyword(s):  
At Risk ◽  
Reproductive Health ◽  
Vitamin K ◽  
Blood Clotting ◽  
Current Evidence ◽  
Vitamin K Deficiency ◽  
Emerging Issues ◽  
K Deficiency

Vitamin K is traditionally recognized for its role in blood clotting. More recently, new roles for vitamin K have emerged. The current evidence for the role of vitamin K in bone, cardiovascular, and reproductive health will be discussed. There will be a particular focus on populations who could be at risk for vitamin K deficiency.

scholarly journals Potential Beneficial Effects of Vitamin K in SARS-CoV-2 Induced Vascular Disease?

Immuno ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 17-29
Author(s):  
Mateusz Kudelko ◽  
Tsz Fung Yip ◽  
Grace Chun Hei Law ◽  
Suki Man Yan Lee
Keyword(s):  
Vascular Disease ◽  
Vitamin K ◽  
Cardiovascular Complications ◽  
Coagulation System ◽  
Vitamin K Deficiency ◽  
Beneficial Effects ◽  
Disease Outcomes ◽  
Potential Benefits ◽  
K Deficiency

Prevalent coagulopathy and thromboembolism are observed in severe COVID-19 patients with 40% of COVID-19 mortality being associated with cardiovascular complications. Abnormal coagulation parameters are related to poor prognosis in COVID-19 patients. Victims also displayed presence of extensive thrombosis in infected lungs. Vitamin K is well-known to play an essential role in the coagulation system. Latest study revealed an existing correlation between vitamin K deficiency and COVID-19 severity, highlighting a role of vitamin K, probably via coagulation modulation. In agreement, other recent studies also indicated that anti-coagulant treatments can reduce mortality in severe cases. Altogether, potential mechanisms linking COVID-19 with coagulopathy in which vitamin K may exert its modulating role in coagulation related with disease pathogenesis are established. In this review, we discuss the recent evidence supporting COVID-19 as a vascular disease and explore the potential benefits of using vitamin K against COVID-19 to improve disease outcomes.

Role of Vitamin A in Induction of Vitamin K Deficiency in the Rat

1962 ◽  
Vol 109 (1) ◽  
pp. 139-142 ◽  
Author(s):  
J. T. Matschiner ◽  
E. A. Doisy
Keyword(s):  
Vitamin A ◽  
Vitamin K ◽  
Vitamin K Deficiency ◽  
K Deficiency

Intracranial hemorrhage and vitamin K deficiency in early infancy

1984 ◽  
Vol 105 (6) ◽  
pp. 880-884 ◽  
Author(s):  
Wun-Tsong Chaou ◽  
Min-Lang Chou ◽  
Donald V. Eitzman
Keyword(s):  
Intracranial Hemorrhage ◽  
Vitamin K ◽  
Early Infancy ◽  
Vitamin K Deficiency ◽  
K Deficiency

Prothrombin And Abnormal (Des-γ-Carboxy) Prothrombin: Assessment Of Plasma Levels By Ria In Disorders Of Hepatic Vitamin K-Dependent Carboxylation

1981 ◽  
Author(s):  
R A Blanchard ◽  
B C Furie ◽  
S F Kruger ◽  
B Furie
Keyword(s):  
Liver Disease ◽  
Vitamin K ◽  
Vitamin K Antagonists ◽  
Vitamin K Deficiency ◽  
Amino Terminal ◽  
Disease States ◽  
Carboxyglutamic Acid ◽  
Precursor Proteins ◽  
Before And After ◽  
K Deficiency

The vitamin K-dependent blood coagulation zymogens contain γ-carboxyglutamic acid (Gla) in their amino terminal domains. The presence of these Gla residues is necessary for the physiologic activation of these zymogens to proteases. The Gla residues are synthesized from glutamic acids on precursor proteins in the liver by a vitamin K-dependent carboxylase. In treatment with vitamin K antagonists or in the presence of vitamin K-deficiency carboxylation is impaired and des-γ-carboxy forms circulate in the blood. We have developed specific RIAs for human prothrombin (NPT) and for des-γ-carboxy human prothrombin (APT) to evaluate the levels of these species in human plasma. These plasma assays measure only NPT despite the presence of APT or only APT despite the presence of NPT.These results suggest that total prothrombin synthesis is decreased in patients treated with warfarin and in patients with intrinsic liver disease compared to normals or to vitamin K-deficient patients. APT is not a component of normal plasma (>0.03 g/ml). However APT is present in 90% of the patients with intrinsic liver disease. In ten patients with liver disease in whom samples were obtained before and after vitamin K administration APT persisted in the plasma. This indicates impaired vitamin-K-dependent car-boxylation in these disorders. We feel that the patterns of plasma NPT and APT in these disease states are characteristic and may prove useful in identifying and distinguishing liver disease from disorders of PT biosynthesis.

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