scholarly journals Visualization of nodal flow that determines left-right asymmetry in the mouse embryo

2013 ◽  
Vol 33 (129) ◽  
pp. 24-27
Author(s):  
Kyosuke SHINOHARA ◽  
Hiroshi HAMADA
Keyword(s):  
Mouse Embryo ◽  
Nodal Flow ◽  
Left Right Asymmetry

scholarly journals Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo

Development ◽  
2012 ◽  
Vol 139 (13) ◽  
pp. 2426-2435 ◽  
Author(s):  
R. S. Saund ◽  
M. Kanai-Azuma ◽  
Y. Kanai ◽  
I. Kim ◽  
M. T. Lucero ◽  
...  
Keyword(s):  
Mouse Embryo ◽  
Lateral Plate Mesoderm ◽  
Lateral Plate ◽  
Left Right Asymmetry ◽  
Gut Endoderm

Determination of left–right patterning of the mouse embryo by artificial nodal flow

Nature ◽  
2002 ◽  
Vol 418 (6893) ◽  
pp. 96-99 ◽  
Author(s):  
Shigenori Nonaka ◽  
Hidetaka Shiratori ◽  
Yukio Saijoh ◽  
Hiroshi Hamada
Keyword(s):  
Mouse Embryo ◽  
Nodal Flow

scholarly journals Left–right asymmetry: cilia stir up new surprises in the node

Open Biology ◽  
2013 ◽  
Vol 3 (5) ◽  
pp. 130052 ◽  
Author(s):  
Deepak Babu ◽  
Sudipto Roy
Keyword(s):  
Gene Expression ◽  
Fluid Transport ◽  
Eukaryotic Cells ◽  
Signal Transduction Pathways ◽  
Cellular Motility ◽  
Nodal Flow ◽  
Vertebrate Embryo ◽  
Sensory Cilia ◽  
Left Right Asymmetry ◽  
Sensory Functions

Cilia are microtubule-based hair-like organelles that project from the surface of most eukaryotic cells. They play critical roles in cellular motility, fluid transport and a variety of signal transduction pathways. While we have a good appreciation of the mechanisms of ciliary biogenesis and the details of their structure, many of their functions demand a more lucid understanding. One such function, which remains as intriguing as the time when it was first discovered, is how beating cilia in the node drive the establishment of left–right asymmetry in the vertebrate embryo. The bone of contention has been the two schools of thought that have been put forth to explain this phenomenon. While the ‘morphogen hypothesis’ believes that ciliary motility is responsible for the transport of a morphogen preferentially to the left side, the ‘two-cilia model’ posits that the motile cilia generate a leftward-directed fluid flow that is somehow sensed by the immotile sensory cilia on the periphery of the node. Recent studies with the mouse embryo argue in favour of the latter scenario. Yet this principle may not be generally conserved in other vertebrates that use nodal flow to specify their left–right axis. Work with the teleost fish medaka raises the tantalizing possibility that motility as well as sensory functions of the nodal cilia could be residing within the same organelle. In the end, how ciliary signalling is transmitted to institute asymmetric gene expression that ultimately induces asymmetric organogenesis remains unresolved.

Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis

Development ◽  
1999 ◽  
Vol 126 (12) ◽  
pp. 2589-2596 ◽  
Author(s):  
C. Chazaud ◽  
P. Chambon ◽  
P. Dolle
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Mouse Embryo ◽  
Time Course ◽  
Retinoic Acid Receptor ◽  
Mouse Embryos ◽  
Anteroposterior Patterning ◽  
Heart Looping ◽  
Left Right Asymmetry

Determination of the left-right position (situs) of visceral organs involves lefty, nodal and Pitx2 genes that are specifically expressed on the left side of the embryo. We demonstrate that the expression of these genes is prevented by the addition of a retinoic acid receptor pan-antagonist to cultured headfold stage mouse embryos, whereas addition of excess retinoic acid leads to their symmetrical expression. Interestingly, both treatments lead to randomization of heart looping and to defects in heart anteroposterior patterning. A time course analysis indicates that only the newly formed mesoderm at the headfold-presomite stage is competent for these retinoid effects. We conclude that retinoic acid, the active derivative of vitamin A, is essential for heart situs determination and morphogenesis.

scholarly journals Generation of Robust Left-Right Asymmetry in the Mouse Embryo Requires a Self-Enhancement and Lateral-Inhibition System

2006 ◽  
Vol 11 (4) ◽  
pp. 495-504 ◽  
Author(s):  
Tetsuya Nakamura ◽  
Naoki Mine ◽  
Etsushi Nakaguchi ◽  
Atsushi Mochizuki ◽  
Masamichi Yamamoto ◽  
...  
Keyword(s):  
Lateral Inhibition ◽  
Mouse Embryo ◽  
Left Right Asymmetry

scholarly journals Nodal Flow and the Generation of Left-Right Asymmetry

Cell ◽  
2006 ◽  
Vol 125 (1) ◽  
pp. 33-45 ◽  
Author(s):  
Nobutaka Hirokawa ◽  
Yosuke Tanaka ◽  
Yasushi Okada ◽  
Sen Takeda
Keyword(s):  
Nodal Flow ◽  
Left Right Asymmetry
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