scholarly journals THE INFLUENCE OF TOTAL PARENTERAL NUTRITION ON THE METABOLISM OF NON-ESTERIFIED FATTY ACIDS IN CRITICALLY ILL PATIENTS: ONGOING DATA FROM A PROSPECTIVE RANDOMIZED STUDY

2019 ◽  
Vol 88 (4) ◽  
pp. 150-158
Author(s):  
Pavel Skořepa ◽  
Joao Fortunato ◽  
Ondřej Sobotka ◽  
Alena Tichá ◽  
Vladimír Bláha ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Randomized Study ◽  
Prospective Randomized Study ◽  
Esterified Fatty Acids

scholarly journals The Impact of Glucose-Based or Lipid-Based Total Parenteral Nutrition on the Free Fatty Acids Profile in Critically Ill Patients

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1373
Author(s):  
Pavel Skorepa ◽  
Ondrej Sobotka ◽  
Jan Vanek ◽  
Alena Ticha ◽  
Joao Fortunato ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Parenteral Nutrition ◽  
Free Fatty Acids ◽  
Total Parenteral Nutrition ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Lipid Emulsions ◽  
Plasminogen Activator Inhibitor 1 ◽  
Mead Acid ◽  
The Impact

Introduction: Our study aim was to assess how the macronutrient intake during total parenteral nutrition (TPN) modulates plasma total free fatty acids (FFAs) levels and individual fatty acids in critically ill patients. Method: Adult patients aged 18–80, admitted to the intensive care unit (ICU), who were indicated for TPN, with an expected duration of more than three days, were included in the study. Isoenergetic and isonitrogenous TPN solutions were given with a major non-protein energy source, which was glucose (group G) or glucose and lipid emulsions (Smof lipid; group L). Blood samples were collected on days 0, 1, 3, 6, 9, 14, and 28. Results: A significant decrease (p < 0.001) in total FFAs occurred in both groups with a bigger decrease in group G (p < 0.001) from day 0 (0.41 ± 0.19 mmol∙L−1) to day 28 (0.10 ± 0.07 mmol∙L−1). Increased palmitooleic acid and decreased linoleic and docosahexaenoic acids, with a trend of increased mead acid to arachidonic acid ratio, on day 28 were observed in group G in comparison with group L. Group G had an insignificant increase in leptin with no differences in the concentrations of vitamin E, triacylglycerides, and plasminogen activator inhibitor-1. Conclusion: Decreased plasma FFA in critically ill patients who receive TPN may result from increased insulin sensitivity with a better effect in group G, owing to higher insulin and glucose dosing and no lipid emulsions. It is advisable to include a lipid emulsion at the latest from three weeks of TPN to prevent essential fatty acid deficiency.

Critically-ill patients receiving total parenteral nutrition show altered amikacin pharmacokinetics

1995 ◽  
Vol 14 (4) ◽  
pp. 254-259 ◽  
Author(s):  
C. Tormo ◽  
F.J. Abad ◽  
C.L. Ronchera-Oms ◽  
V. Parra ◽  
N.V. Jiménez
Keyword(s):  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Critically Ill ◽  
Critically Ill Patients

Stability of Famotidine in Minibags Refrigerated and/or Frozen in Total Parenteral Nutrition Solutions

DICP ◽  
1989 ◽  
Vol 23 (10_suppl) ◽  
pp. S44-S46
Author(s):  
Linda S. Bullock
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Parenteral Nutrition ◽  
Gastrointestinal Bleeding ◽  
Total Parenteral Nutrition ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Room Temperature ◽  
Acid Solutions ◽  
Amino Acid Solutions

The use of histamine2-receptor antagonists could be beneficial in critically ill patients for protection against stress-induced gastrointestinal bleeding. Famotidine, similar to cimetidine and ranitidine, is stable when mixed in dextrose 5% injection and NaCl 0.9% injection at a concentration of 200 μg/mL and stored in polyvinyl chloride bags at 4 °C for 14 days or when frozen for 28 days and subsequently refrigerated for 14 days. Furthermore, famotidine, also like cimetidine and ranitidine, is stable when added to most common total parenteral nutrition (TPN) solutions. Famotidine in concentrations of 20 mg/L and 40 mg/L is stable in crystalline amino acid solutions (20 g/L and 42.5 g/L) when refrigerated for 24 hours, then held at room temperature for 24 hours, at room temperature for 48 hours, or refrigerated for seven days. The concentration of amino acids in the TPN solutions containing 42.5 g/L also is not affected by the addition of famotidine 40 mg/L when stored under conditions similar to those stated above for 48 hours. TPN solutions remain clear and free of turbidity.

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