scholarly journals PROTECTIVE EFFECT OF AQUEOUS EXTRACTS OF AFRAMOMUM MELEGUETA ON γ-RADIATION-INDUCED LIVER DAMAGE IN MALE WISTAR RATS

2013 ◽  
Vol 82 (3) ◽  
pp. 126-132
Author(s):  
S. O. Nwozo ◽  
O. F. Yakubu ◽  
B. E. Oyinloye
Keyword(s):  
Protective Effect ◽  
Liver Damage ◽  
Wistar Rats ◽  
Aqueous Extracts ◽  
Γ Radiation ◽  
Male Wistar Rats ◽  
Radiation Induced

Protective effect of an antithyroid compound against γ-radiation-induced damage in human colon cancer cells

2014 ◽  
Vol 53 (3) ◽  
pp. 611-619
Author(s):  
Marina Perona ◽  
Maria A. Dagrosa ◽  
Romina Pagotto ◽  
Mariana Casal ◽  
Omar Pignataro ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protective Effect ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Γ Radiation ◽  
Radiation Induced ◽  
Human Colon Cancer Cells

Aqueous extract of Cola nitida and Garcinia kola synergistically enhances hippocampal-hypothalamic glutamate and Na+/K+-ATPase activity in male Wistar rats

2021 ◽  
Vol 18 ◽  
Author(s):  
Kehinde S. Olaniyi ◽  
Isaiah W. Sabinari ◽  
Adesola A. Oniyide ◽  
Nifesimi T. Akinnagbe ◽  
Toluwani B. Agunbiade ◽  
...  
Keyword(s):  
Atpase Activity ◽  
Wistar Rats ◽  
Concomitant Administration ◽  
Energy Regulation ◽  
Aqueous Extracts ◽  
Garcinia Kola ◽  
Or Management ◽  
Male Wistar Rats ◽  
Susceptible Populations ◽  
Cola Nitida

Background: The incidence of cognitive decline has been proposed to rise exponentially in coming years. Therapies targeting molecular pathways involved in enhancement of memory and energy regulation could be a major breakthrough in prevention or management of dementia in susceptible populations. Objectives: This study investigated the effects of aqueous extracts of Cola nitida (AECONS) and Garcinia kola (AEGAK) on glutamate level and Na+/K+-ATPase activity in the hippocampus and hypothalamus of male Wistar rats. Methods: Adult male Wistar rats (170-200) were randomly allotted into groups (n=5/group); control (distilled water p.o.), AECONS1 (200 mg/kg), AECONS2 (400 mg/kg), AEGAK1 (200 mg/kg), AEGAK2 (400 mg/kg), AECONS1+AEGAK1 and AECONS2+AEGAK2. The extract was prepared and the administration was done daily for 6 weeks. Results and Discussion: Administration of AECONS or AEGAK increased plasma, hippocampal and hypothalamic glutamate, Na+/K+-ATPase activity, NO, SOD except hippocampal glutamate in AECONS1/AEGAK1, Na+/K+-ATPase activity and SOD in AEGAK1, hypothalamic glutamate and SOD in AECONS1 when compared with control. Besides, MDA level decreased in AEGAK2 and hippocampal but not hypothalamic MDA decreased in AEGAK1 compared with control. However, concomitant administration of AECONS and AEGAK enhanced plasma, hippocampal and hypothalamic biomarkers except hypothalamic MDA level. The present study demonstrates that AECONS and AEGAK synergistically enhances hippocampal and hypothalamic glutamate and Na+/K+-ATPase activity, which are accompanied by NO and SOD-dependent antioxidant enrichment. Conclusion: These findings therefore suggest that AECONS+AEGAK could be a better therapeutic candidate in hippocampal-hypothalamic-related neurodegenerative diseases.

scholarly journals Hepatoprotective Potentials of Aqueous extracts of Ficus asperifolia MIQ leaves on CCl4 induced liver damage in Wistar rats

2017 ◽  
Vol 4 (12) ◽  
pp. 27-39
Author(s):  
R.O Opotu ◽  
◽  
A.A Uwakwe ◽  
L.C Chuku ◽  
V Olua ◽  
...  
Keyword(s):  
Liver Damage ◽  
Wistar Rats ◽  
Aqueous Extracts
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