scholarly journals ON THE UNIVERSALITY OF OXIME HLö-7 - ANTIDOTE FOR CASE OF THE NERVE AGENT POISONING

2011 ◽  
Vol 80 (2) ◽  
pp. 80-84 ◽  
Author(s):  
Kamil Kuča ◽  
Kamil Musílek ◽  
Jana Karasová ◽  
Daniel Jun ◽  
Ondřej Soukup ◽  
...  
Keyword(s):  
Nerve Agent ◽  
Hlö 7

scholarly journals A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in Mice

1998 ◽  
Vol 41 (1) ◽  
pp. 19-21 ◽  
Author(s):  
Jiří Kassa
Keyword(s):  
Therapeutic Efficacy ◽  
Nerve Agent ◽  
Hi 6 ◽  
Hlö 7

1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly more efficacious than conventional oximes but a little less efficacious than other H-oximes (HI- 6, HLö-7). 3. H-oximes (HI-6, HLö-7) seem to be the most efficacious reactivators of nerve agent-inhibited acetylcholinesterase for antidotal treatment of supralethal nerve agent poisoning in mice.

scholarly journals Synthesis and Molecular Properties of Nerve Agent Reactivator HLö-7 Dimethanesulfonate

2019 ◽  
Vol 10 (5) ◽  
pp. 761-766 ◽  
Author(s):  
Fu-Lian Hsu ◽  
Su Y. Bae ◽  
Jack McGuire ◽  
Dana R Anderson ◽  
Stephanie M. Bester ◽  
...  
Keyword(s):  
Nerve Agent ◽  
Molecular Properties ◽  
Hlö 7

scholarly journals A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods

2005 ◽  
Vol 48 (2) ◽  
pp. 81-86 ◽  
Author(s):  
Kamil Kuča ◽  
Jiří Cabal ◽  
Jiří Kassa ◽  
Daniel Jun ◽  
Martina Hrabinová
Keyword(s):  
Rat Brain ◽  
Nerve Agents ◽  
Nerve Agent ◽  
The Other ◽  
In Vitro Evaluation ◽  
In Vitro Methods ◽  
Hi 6 ◽  
Hlö 7 ◽  
Brain Acetylcholinesterase

1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6) were found to be more efficacious reactivators of sarin and VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase is very low and does not reach the reactivating efficacy of obidoxime. In the case of cyclosarin, the oxime HI-6 was only found to be able to sufficiently reactivate cyclosarin-inhibited acetylcholinesterase in vitro. 3. Thus, the oxime HLö-7 does not seem to be more efficacious reactivator of nerve agent-inhibited acetylcholinesterase than HI-6 according to in vitro evaluation of their reactivation potency and, therefore, it is not more suitable to be introduced for antidotal treatment of nerve agent-exposed people than HI-6.

Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice

1992 ◽  
Vol 66 (3) ◽  
pp. 216-219 ◽  
Author(s):  
John G. Clement ◽  
Arnold S. Hansen ◽  
Camille A. Boulet
Keyword(s):  
Nerve Agent ◽  
Hlö 7

Efficacy of HI-6 and HLö-7 in preventing incapacitation following nerve agent poisoning

1994 ◽  
Vol 49 (4) ◽  
pp. 781-788 ◽  
Author(s):  
Bert P.C. Melchers ◽  
Ingrid H.C.H.M. Philippens ◽  
Otto L. Wolthuis
Keyword(s):  
Nerve Agent ◽  
Hi 6 ◽  
Hlö 7

Neurotrophin Expression in Nerve Agent VX-Exposed Rat Brain

2007 ◽  
Author(s):  
Santresda M. Johnson ◽  
Chris L. Robison ◽  
Tsung-Ming A. Shih ◽  
Lawrence Tong ◽  
Sarah Parylak ◽  
...  
Keyword(s):  
Rat Brain ◽  
Nerve Agent

The Role of DARPP-32, an Intracellular Signaling Molecule, in the Actions of the Nerve Agent Sarin

2005 ◽  
Author(s):  
Tsung-Ming Shih ◽  
Gretchen L. Snyder ◽  
Allen A. Fienberg ◽  
Stacey Galdi ◽  
Minal Rana ◽  
...  
Keyword(s):  
Intracellular Signaling ◽  
Nerve Agent ◽  
Signaling Molecule

Evaluation of ADD392124 for the Delayed Treatment of Nerve Agent-Induced Status Epilepticus Seizures

2011 ◽  
Author(s):  
John H. McDonough ◽  
Kerry E. Van Shura ◽  
Megan E. Lyman ◽  
Claire G. Eisner ◽  
Amelia Mazza ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Nerve Agent ◽  
Delayed Treatment
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