Therapeutic angiogenesis by bone marrow mononuclear cell transplantation: Limitation in the elderly and augmentation by angiopoietin 1 gene therapy

2007 ◽  
Vol 44 (1) ◽  
pp. 65-68
Author(s):  
Takahisa Kondo ◽  
Koichi Kobayashi ◽  
Natsuo Inoue ◽  
Hideo Izawa ◽  
Satoshi Shintani ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bone Marrow ◽  
Cell Transplantation ◽  
Mononuclear Cell ◽  
The Elderly ◽  
Therapeutic Angiogenesis ◽  
Bone Marrow Mononuclear Cell ◽  
Angiopoietin 1

scholarly journals Efficacy of autologous bone marrow mononuclear cell transplantation in dogs with chronic spinal cord injury

2020 ◽  
Vol 10 (2) ◽  
pp. 206-215
Author(s):  
Katsutoshi Tamura ◽  
Noritaka Maeta
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Cell Transplantation ◽  
Mononuclear Cell ◽  
Motor Neurons ◽  
Research Work ◽  
Autologous Bone Marrow ◽  
Bone Marrow Mononuclear Cell ◽  
Cord Injury

Background: Spinal cord injury (SCI) is relatively common in dogs and is a devastating condition involving loss of sensory neurons and motor  neurons. However, the main clinical protocol for the management of SCI is surgery to decompress and stabilize the vertebra. Cell transplantation therapy is a very promising strategy for the treatment of chronic SCI, but extensive preclinical and clinical research work remains.Aim: The aim of this study is to confirm the effect of bone marrow-derived mononuclear cell (BM-MNC) transplantation for chronic SCI in dogs.Methods: We tested the treatment efficiency of chronic SCI in 12 dogs using BM-MNC transplantation. Neurological evaluation used the Texas Spinal Cord Injury Scale (TSCIS). Concurrently, we characterized the transplanted cells by evaluation using quantitative real-time polymerase chain reaction, flow cytometry, and enzyme-linked immunosorbent assay.Result: All dogs had a pre-transplantation TSCIS score of 0. Two animals did not show any improvement in their final TSCIS scores. The remaining 10 dogs (83.4%) achieved improvement in the final TSCIS scores. Five of them (41.7%) regained ambulatory function with a TSCIS score greater than 10. We determined that canine BM-MNCs expressed hepatocyte growth factor (HGF) mRNA at higher levels than other cytokines, with significant  increases in HGF levels in cerebrospinal fluid within 48 hours after autologous BM-MNC transplantation into the subarachnoid space of the spinal dura matter in dogs.Conclusions: BM-MNC transplantation may be effective for at least some cases of chronic SCI. Keywords: Bone marrow-derived mononuclear cell, Cell therapy, Spinal cord injury.

A pilot study of autologous CD34-depleted bone marrow mononuclear cell transplantation via the hepatic artery in five patients with liver failure

Cytotherapy ◽  
2013 ◽  
Vol 15 (12) ◽  
pp. 1571-1579 ◽  
Author(s):  
Chung-Hwa Park ◽  
Si Hyun Bae ◽  
Hee Yeon Kim ◽  
Ja Kyung Kim ◽  
Eun Sun Jung ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Pilot Study ◽  
Liver Failure ◽  
Hepatic Artery ◽  
Cell Transplantation ◽  
Mononuclear Cell ◽  
Bone Marrow Mononuclear Cell
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