scholarly journals An elderly autopsy case of chronic myelomonocytic leukemia with infiltration of a giant liver cyst and multiple organs

2007 ◽  
Vol 44 (4) ◽  
pp. 507-512 ◽  
Author(s):  
Tomotaka Akai ◽  
Masayuki Kikawada ◽  
Akihiro Kimura ◽  
Masayuki Kikukawa ◽  
Akihiro Kiuchi ◽  
...  
Keyword(s):  
Liver Cyst ◽  
Chronic Myelomonocytic Leukemia ◽  
Autopsy Case ◽  
Multiple Organs ◽  
Myelomonocytic Leukemia ◽  
Giant Liver Cyst

scholarly journals Hydroxyurea-induced Pneumonitis in a Patient with Chronic Myelomonocytic Leukemia: An Autopsy Case

2015 ◽  
Vol 54 (24) ◽  
pp. 3171-3176 ◽  
Author(s):  
Hisao Imai ◽  
Nozomi Matsumura ◽  
Yuichi Yamazaki ◽  
Yuki Kanayama ◽  
Tomomi Masuda ◽  
...  
Keyword(s):  
Chronic Myelomonocytic Leukemia ◽  
Autopsy Case ◽  
Myelomonocytic Leukemia

scholarly journals Vasculitis associated with myelodysplastic syndrome and chronic myelomonocytic leukemia: French multicenter case-control study

2020 ◽  
Vol 50 (5) ◽  
pp. 879-884
Author(s):  
Anne Laure Roupie ◽  
Alexis Guedon ◽  
Benjamin Terrier ◽  
Constance Lahuna ◽  
Vincent Jachiet ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Case Control Study ◽  
Case Control ◽  
Chronic Myelomonocytic Leukemia ◽  
Myelomonocytic Leukemia ◽  
Control Study

Trisomy 19 as the sole chromosomal abnormality in proliferative chronic myelomonocytic leukemia

2006 ◽  
Vol 30 (8) ◽  
pp. 1043-1047 ◽  
Author(s):  
M. Daskalakis ◽  
N. Mauritzson ◽  
B. Johansson ◽  
K. Bouabdallah ◽  
F. Onida ◽  
...  
Keyword(s):  
Chromosomal Abnormality ◽  
Chronic Myelomonocytic Leukemia ◽  
Myelomonocytic Leukemia

scholarly journals Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish

Leukemia ◽  
2021 ◽  
Author(s):  
Xiao Fang ◽  
Song’en Xu ◽  
Yiyue Zhang ◽  
Jin Xu ◽  
Zhibin Huang ◽  
...  
Keyword(s):  
Myeloid Leukemia ◽  
Chronic Myelomonocytic Leukemia ◽  
Nonsense Mutations ◽  
Myeloid Malignancies ◽  
A Subunit ◽  
Neutrophil Differentiation ◽  
Polycomb Repressive Complex 1 ◽  
Myelomonocytic Leukemia ◽  
Inhibitor Treatment ◽  
Acute Myeloid

AbstractASXL1 is one of the most frequently mutated genes in malignant myeloid diseases. In patients with myeloid malignancies, ASXL1 mutations are usually heterozygous frameshift or nonsense mutations leading to C-terminal truncation. Current disease models have predominantly total loss of ASXL1 or overexpressed C-terminal truncations. These models cannot fully recapitulate leukemogenesis and disease progression. We generated an endogenous C-terminal-truncated Asxl1 mutant in zebrafish that mimics human myeloid malignancies. At the embryonic stage, neutrophil differentiation was explicitly blocked. At 6 months, mutants initially exhibited a myelodysplastic syndrome-like phenotype with neutrophilic dysplasia. At 1 year, about 13% of mutants further acquired the phenotype of monocytosis, which mimics chronic myelomonocytic leukemia, or increased progenitors, which mimics acute myeloid leukemia. These features are comparable to myeloid malignancy progression in humans. Furthermore, transcriptome analysis, inhibitor treatment, and rescue assays indicated that asxl1-induced neutrophilic dysplasia was associated with reduced expression of bmi1a, a subunit of polycomb repressive complex 1 and a reported myeloid leukemia-associated gene. Our model demonstrated that neutrophilic dysplasia caused by asxl1 mutation is a foundation for the progression of myeloid malignancies, and illustrated a possible effect of the Asxl1-Bmi1a axis on regulating neutrophil development.

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