scholarly journals Recent Progress in the Treatment of Elderly Patients with Cardiovascular Diseases.

1992 ◽  
Vol 29 (2) ◽  
pp. 89-94
Author(s):  
O. Iimura
Keyword(s):  
Cardiovascular Diseases ◽  
Elderly Patients ◽  
Recent Progress

scholarly journals A Review of CXCL1 in Cardiac Fibrosis

2021 ◽  
Vol 8 ◽  
Author(s):  
Cheng-Long Wu ◽  
Ran Yin ◽  
Su-Nan Wang ◽  
Ru Ying
Keyword(s):  
Cardiovascular Diseases ◽  
Serum Level ◽  
Inflammatory Reaction ◽  
Cardiac Remodeling ◽  
Recent Progress ◽  
Cardiac Fibrosis ◽  
Elevated Serum ◽  
Inflammatory Factor ◽  
Growing Body

Chemokine C-X-C motif ligand-1 (CXCL1), principally expressed in neutrophils, macrophages and epithelial cells, is a valid pro-inflammatory factor which performs an important role in mediating the infiltration of neutrophils and monocytes/macrophages. Elevated serum level of CXCL1 is considered a pro-inflammatory reaction by the organism. CXCL1 is also related to diverse organs fibrosis according to relevant studies. A growing body of evidence suggests that CXCL1 promotes the process of cardiac remodeling and fibrosis. Here, we review structure and physiological functions of CXCL1 and recent progress on the effects and mechanisms of CXCL1 in cardiac fibrosis. In addition, we explore the role of CXCL1 in the fibrosis of other organs. Besides, we probe the possibility that CXCL1 can be a therapeutic target for the treatment of cardiac fibrosis in cardiovascular diseases.

scholarly journals MicroRNA-143/-145 in Cardiovascular Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Wang Zhao ◽  
Shui-Ping Zhao ◽  
Yu-Hong Zhao
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular Diseases ◽  
Vascular Smooth Muscle Cells ◽  
Essential Role ◽  
Recent Progress ◽  
Potential Role ◽  
Phenotypic Switching ◽  
Diagnostic Biomarkers ◽  
Potential Strategy

MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of vascular smooth muscle cells (VSMCs) and determines VSMC phenotypic switching. In this review, we summarize the recent progress in knowledge concerning the function of miR-143/-145 in the cardiovascular system and their role in cardiovascular diseases. We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145.

Urological Surgery in Elderly Patients: Results and Considerations - Part II

1992 ◽  
Vol 59 (4) ◽  
pp. 31-35 ◽  
Author(s):  
M. Pizzarella ◽  
G. Ferro ◽  
F. Invidiato ◽  
P. Ligato ◽  
M. Fiorello ◽  
...  
Keyword(s):  
Numerical Analysis ◽  
Cardiovascular Diseases ◽  
Elderly Patients ◽  
The Elderly ◽  
Average Life ◽  
Average Life Span ◽  
Urological Surgery ◽  
Incidence And Mortality ◽  
Age Limits ◽  
Surgery In Elderly

It is certainly true that increase of the average life span has caused a greater percentage of elderly people to visit urological departments. From April 1989 to December 1991, patients over 75 years under our observation were 10.8% of all operated patients. Only 5% of patients over 75 who needed to be operated, weren't actually operated. The numerical analysis of our experience has highlighted the fact that in patients who underwent an operation, the incidence and mortality caused by cardiovascular diseases weren't any higher than those found in other people of the same age. We are also convinced that prejudices about age limits should not prevent the elderly afflicted with a benign or malignant urological pathology from undergoing an operation.

scholarly journals Readmission after hospitalization for heart failure in elderly patients in Chapidze Emergency Cardiology Center, Georgia

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Tengiz Verulava ◽  
Revaz Jorbenadze ◽  
Ana Lordkipanidze ◽  
Ana Gongadze ◽  
Michael Tsverava ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Diseases ◽  
Elderly Patients ◽  
Population Aging ◽  
Major Complication ◽  
Multivariate Logistic Regression Model ◽  
Readmission Rates ◽  
Content Type ◽  
Initial Hospitalization ◽  
Mortality Causes

PurposeHeart Failure (HF) is one of the leading mortality causes in elderly people. The purpose of this study is to assess readmission rates and reasons in elderly patients with HF.Design/methodology/approachThe authors explored medical records of elderly patients with HF (75 years and more) at Chapidze Emergency Cardiology Center (Georgia) from 2015 to 2019. The authors analyzed the structure of the cardiovascular diseases and readmission rates of hospitalized patients with HF (I50, I50.0 I50.1). A multivariate logistic regression model was used to identify factors, associated with readmission for any reason during 6–9 months after the initial hospitalization for HF.FindingsThe major complication of cardiovascular diseases in elderly patients is HF (68.6%). Hospitalization rates due to HF in elderly patients have increased in recent years, which is associated with the population aging process. This trend will be most likely continue. Despite significant improvements in HF treatment, readmission rates are still high. HF is the most commonly revealed cause of readmission (48% of all readmissions). About 6–9 months after the primary hospitalization due to HF, readmission for any reason was 60%. Patients had concomitant diseases, including hypertension (43%), myocardial infarction (14%), diabetes (36%) and stroke (8%), affecting the readmission rate.Originality/valueHF remains an important problem in public health. During HF-associated hospitalizations, both cardiac and non-cardiac conditions should be addressed, which has the potential for health problems and disease progression. Some readmissions may be prevented by the proper selection of medicines and monitoring.

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