scholarly journals Diagnostic Accuracy of Single Photon Emission CT in Alzheimer-Type Dementia.

1992 ◽  
Vol 29 (6) ◽  
pp. 463-468 ◽  
Author(s):  
Haruo Hanyu ◽  
Shinei Abe ◽  
Hisayuki Arai ◽  
Tetsuichi Asano ◽  
Toshihiko Iwamoto ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Single Photon ◽  
Photon Emission ◽  
Alzheimer Type ◽  
Single Photon Emission ◽  
Alzheimer Type Dementia ◽  
Single Photon Emission Ct

New Cardiac Cameras: Single-Photon Emission CT and PET

2014 ◽  
Vol 44 (4) ◽  
pp. 232-251 ◽  
Author(s):  
Piotr J. Slomka ◽  
Daniel S. Berman ◽  
Guido Germano
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Single Photon Emission ◽  
Single Photon Emission Ct

scholarly journals Limited value of99mTc depreotide single photon emission CT compared with CT for the evaluation of pulmonary lesions

2012 ◽  
Vol 85 (1015) ◽  
pp. e307-e313 ◽  
Author(s):  
S W Harders ◽  
H H Madsen ◽  
K Hjorthaug ◽  
M Rehling ◽  
T R Rasmussen ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Single Photon Emission ◽  
Pulmonary Lesions ◽  
Single Photon Emission Ct

A Single Photon Emission Computerised Tomography Study of Regional Brain Function Underlying Verbal Memory in Patients with Alzheimer-Type Dementia

1993 ◽  
Vol 163 (2) ◽  
pp. 166-172 ◽  
Author(s):  
W. Riddle ◽  
R. E. O'Carroll ◽  
N. Dougall ◽  
M. Van Beck ◽  
C. Murray ◽  
...  
Keyword(s):  
Parietal Cortex ◽  
Verbal Memory ◽  
Single Photon ◽  
Photon Emission ◽  
Memory Task ◽  
Recognition Task ◽  
Tracer Uptake ◽  
Anterior Cingulate ◽  
Alzheimer Type ◽  
Alzheimer Type Dementia

Ten patients with Alzheimer-type dementia and nine age-matched normal controls were examined with SPECT, using split-dose 99mTc-labelled exametazime. The baseline condition involved repetition of the word ‘yes' or ‘no’. The activation condition involved recognition (indicated by a ‘yes' or ‘no’) of words from a previously learned list presented along with distractor words. Patients who performed this task successfully were selected, and efforts were made to match the patients with controls according to their performance on the task, although this was not fully achieved. Uptake of 99mTc-exametazime was estimated at baseline and during the word-recognition task for predetermined regions of interest drawn from a standard neuroanatomical atlas. The baseline task appeared to normalise tracer uptake for frontal, temporal and parietal cortex in the patient group. However, during the recognition task, controls but not patients showed activation effects. These were most prominent in dorsolateral frontal cortex and adjacent anterior cingulate cortex. Among patients, successful performance was correlated with activation of dorsolateral frontal and parietal cortex on the left side. The results confirm the central role of frontal mechanisms in a recognition memory task. The study highlights some of the difficulties of using cognitive challenge tests in clinical groups.

A Single Photon Emission Computerised Tomography Study of Regional Brain Function in Elderly Patients with Major Depression and with Alzheimer-Type Dementia

1993 ◽  
Vol 163 (2) ◽  
pp. 155-165 ◽  
Author(s):  
S. M. Curran ◽  
C. M. Murray ◽  
M. Van Beck ◽  
N. Dougall ◽  
R. E. O'Carroll ◽  
...  
Keyword(s):  
Brain Function ◽  
Single Photon ◽  
Photon Emission ◽  
Anterior Cingulate ◽  
Association Cortex ◽  
Elderly Subjects ◽  
Alzheimer Type ◽  
Cross Sectional ◽  
Depressed Patients ◽  
Alzheimer Type Dementia

The uptake, at rest, of 99mTc-exametazime into different brain regions was compared using SPECT for 20 elderly subjects with major depressive disorder, 20 with Alzheimer-type dementia, and 30 age-matched normal volunteers. Uptake was referred to calcarine-occipital cortex as a reference sensory area. Cross-sectional differences between the three groups were highly statistically significant, but reflected primarily the reductions in cortical uptake in the Alzheimer group. A detailed comparison of depressed patients and controls identified decrements in anterior cingulate, temporal and frontal cortex and in caudate and thalamus in men only. These decrements were correlated with impairment of performance on a trail-making task, but were also associated with continuing treatment with antidepressants or benzodiazepines. However, most depressed patients had quantitatively normal scans for posterior parietal association cortex, and this suggests that SPECT may find a limited role in the differential diagnosis of depression and dementia. The reduced brain function in some depressed patients may parallel the findings from studies of brain structure in elderly depressives; there was a weak association between good outcome at 6–18 months and increased tracer uptake in subcortical areas.

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