scholarly journals Fabrication and Characterization of Electrospun Thermoplastic Polyurethane/Fibroin Small-Diameter Vascular Grafts for Vascular Tissue Engineering

2016 ◽  
Vol 31 (5) ◽  
pp. 638-646 ◽  
Author(s):  
E. Yu ◽  
J. Zhang ◽  
J. A. Thomson ◽  
L.-S. Turng
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Thermoplastic Polyurethane ◽  
Vascular Grafts ◽  
Small Diameter ◽  
Vascular Tissue Engineering ◽  
Fabrication And Characterization ◽  
Small Diameter Vascular Grafts

scholarly journals Vascular Tissue Engineering: Recent Advances in Small Diameter Blood Vessel Regeneration

2014 ◽  
Vol 2014 ◽  
pp. 1-27 ◽  
Author(s):  
Valentina Catto ◽  
Silvia Farè ◽  
Giuliano Freddi ◽  
Maria Cristina Tanzi
Keyword(s):  
Tissue Engineering ◽  
Cardiovascular Diseases ◽  
Blood Vessel ◽  
Polyethylene Terephthalate ◽  
Vascular Tissue ◽  
Vascular Grafts ◽  
Small Diameter ◽  
Synthetic Polymers ◽  
Vascular Tissue Engineering ◽  
Vessel Regeneration

Cardiovascular diseases are the leading cause of mortality around the globe. The development of a functional and appropriate substitute for small diameter blood vessel replacement is still a challenge to overcome the main drawbacks of autografts and the inadequate performances of synthetic prostheses made of polyethylene terephthalate (PET, Dacron) and expanded polytetrafluoroethylene (ePTFE, Goretex). Therefore, vascular tissue engineering has become a promising approach for small diameter blood vessel regeneration as demonstrated by the increasing interest dedicated to this field. This review is focused on the most relevant and recent studies concerning vascular tissue engineering for small diameter blood vessel applications. Specifically, the present work reviews research on the development of tissue-engineered vascular grafts made of decellularized matrices and natural and/or biodegradable synthetic polymers and their realization without scaffold.

Fabrication and characterization of electrospun gelatin-heparin nanofibers as vascular tissue engineering

2013 ◽  
Vol 21 (8) ◽  
pp. 860-869 ◽  
Author(s):  
Heyun Wang ◽  
Yakai Feng ◽  
Zichen Fang ◽  
Ruofang Xiao ◽  
Wenjie Yuan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Fabrication And Characterization ◽  
Electrospun Gelatin

Engineering blood vessels and vascularized tissues: technology trends and potential clinical applications

2019 ◽  
Vol 133 (9) ◽  
pp. 1115-1135 ◽  
Author(s):  
Prafulla Chandra ◽  
Anthony Atala
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Grafts ◽  
Small Diameter ◽  
Clinical Applications ◽  
Angiogenic Factors ◽  
Vascular Tissue Engineering ◽  
Technology Trends

Abstract Vascular tissue engineering has the potential to make a significant impact on the treatment of a wide variety of medical conditions, including providing in vitro generated vascularized tissue and organ constructs for transplantation. Since the first report on the construction of a biological blood vessel, significant research and technological advances have led to the generation of clinically relevant large and small diameter tissue engineered vascular grafts (TEVGs). However, developing a biocompatible blood-contacting surface is still a major challenge. Researchers are using biomimicry to generate functional vascular grafts and vascular networks. A multi-disciplinary approach is being used that includes biomaterials, cells, pro-angiogenic factors and microfabrication technologies. Techniques to achieve spatiotemporal control of vascularization include use of topographical engineering and controlled-release of growth/pro-angiogenic factors. Use of decellularized natural scaffolds has gained popularity for engineering complex vascularized organs for potential clinical use. Pre-vascularization of constructs prior to implantation has also been shown to enhance its anastomosis after implantation. Host-implant anastomosis is a phenomenon that is still not fully understood. However, it will be a critical factor in determining the in vivo success of a TEVGs or bioengineered organ. Many clinical studies have been conducted using TEVGs, but vascularized tissue/organ constructs are still in the research & development stage. In addition to technical challenges, there are commercialization and regulatory challenges that need to be addressed. In this review we examine recent advances in the field of vascular tissue engineering, with a focus on technology trends, challenges and potential clinical applications.

Multilayer Hybrid Construct for Vascular Tissue Engineering

2011 ◽  
Author(s):  
Krishna Madhavan ◽  
Walter Bonani ◽  
Wei Tan
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Grafts ◽  
Small Diameter ◽  
Vascular Tissue Engineering ◽  
Graft Material ◽  
Cell Assays ◽  
Recent Developments ◽  
And Function

Vascular grafts are often used as blood vessel substitutes. Until now, synthetic materials have not matched the efficacy of native tissues, particularly in the applications of small-diameter vascular grafts (<6mm) such as bypass grafts for arthrosclerosis and vascular access graft for hemodialysis. There is a considerable need for alternatives to the autologous veins or arteries. Many patients do not have an autologous vessel suitable for use due to preexisting pathological conditions or previous surgical harvest. Recent developments in vascular tissue engineering demonstrate the possibility of a biodegradable graft material containing living cells to mimic the structure and function of native vessels. However, fabrication of biomimetic grafts is often time and labor intensive, and subsequently requires complicated storage. This demands technology advancements in producing vessel mimetic grafts, considering their availability in addition to efficacy. To this end, new approaches to constructing small-diameter grafts that are of immediate availability and capable of regenerating biomimetic blood vessels in vivo may address the unmet demand in this area. We have designed a novel multilayer vascular construct which is made up of a nanofibrous “intima-equivalent” with thrombus-resistant vessel lumen and a porous biopolymer matrix as “media-equivalent” to allow smooth muscle cells (SMC) from native artery to grow and remodel the tissue. In this study, various layering strategies have been explored. To evaluate the resultant multilayer construct, structural, biochemical and biomechanical characterizations, as well as cell assays and short-term animal studie have been performed.

Fabrication of PCL/keratin composite scaffolds for vascular tissue engineering with catalytic generation of nitric oxide potential

2020 ◽  
Vol 8 (28) ◽  
pp. 6092-6099
Author(s):  
Pengfei Li ◽  
Yanfang Wang ◽  
Xingxing Jin ◽  
Jie Dou ◽  
Xiao Han ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tissue Engineering ◽  
Blood Vessel ◽  
Vascular Tissue ◽  
Vascular Grafts ◽  
Small Diameter ◽  
Vascular Tissue Engineering ◽  
Composite Scaffolds ◽  
Promising Solution ◽  
Blood Vessel Substitutes

Tissue-engineered vascular grafts (TEVGs) have been proposed as a promising solution to fulfill the need for small-diameter blood vessel substitutes.

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