Development of gamma spectroscopy employing NaI(Tl) detector 3 inch × 3 inch and readout electronic of flash-ADC/FPGA-based technology

Kerntechnik ◽  
2015 ◽  
Vol 80 (2) ◽  
pp. 180-183
Author(s):  
Vo Hong Hai ◽  
Nguyen Quoc Hung ◽  
Bui Tuan Khai
Keyword(s):  
Gamma Spectroscopy ◽  
Flash Adc ◽  
Readout Electronic

scholarly journals Development of triggering and DAQ systems for radiation detectors using FPGA technology

2017 ◽  
Vol 1 (T4) ◽  
pp. 197-204
Author(s):  
Hai Hong Vo ◽  
Hung Quoc Nguyen ◽  
Tuyet Kim Tran
Keyword(s):  
Pulse Generator ◽  
Cosmic Ray ◽  
Digital Processing ◽  
Radiation Detectors ◽  
Induced Response ◽  
Environmental Radiation ◽  
Flash Adc ◽  
Readout Electronic ◽  
Field Programmable ◽  
Radiation Sensors

Field-programmable gate array (FPGA) technology has been widely used in setting up triggering systems and DAQ systems for radiation detectors, because it has several advantages such as fast digital processing, compact, programmable and high stability. Since 2010, with we have developed FPGA-based trigger systems and FPGA-based DAQ systems used for radiation detectors. Triggering systems for cosmic ray measurements, readout electronic for environmental radiation monitor in air. We also developed nuclear electronic equipment such as spectrum analyzer MCA (Flash-ADC/FPGA based), the pulse generator, counters, readout electronic for multiple radiation sensors. In this paper, we present two experiments, on the cosmic-ray induced response on the NaI(Tl) detector and environmental radiation monitoring system. For those experiments, trigger system are built by FPGA-based technology.

A 5-bit 4.2-GS/s Flash ADC in 0.13-µm CMOS Process

2009 ◽  
Vol E92-C (2) ◽  
pp. 258-268 ◽  
Author(s):  
Ying-Zu LIN ◽  
Soon-Jyh CHANG ◽  
Yen-Ting LIU
Keyword(s):  
Cmos Process ◽  
Flash Adc

scholarly journals Development of a blood sample detector for multi-tracer positron emission tomography using gamma spectroscopy

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Carlos Velasco ◽  
Adriana Mota-Cobián ◽  
Jesús Mateo ◽  
Samuel España
Keyword(s):  
Positron Emission Tomography ◽  
Blood Sample ◽  
Pet Imaging ◽  
Spectroscopic Analysis ◽  
Gamma Spectroscopy ◽  
Emission Tomography ◽  
Blood Samples ◽  
Positron Emission

Abstract Background Multi-tracer positron emission tomography (PET) imaging can be accomplished by applying multi-tracer compartment modeling. Recently, a method has been proposed in which the arterial input functions (AIFs) of the multi-tracer PET scan are explicitly derived. For that purpose, a gamma spectroscopic analysis is performed on blood samples manually withdrawn from the patient when at least one of the co-injected tracers is based on a non-pure positron emitter. Alternatively, these blood samples required for the spectroscopic analysis may be obtained and analyzed on site by an automated detection device, thus minimizing analysis time and radiation exposure of the operating personnel. In this work, a new automated blood sample detector based on silicon photomultipliers (SiPMs) for single- and multi-tracer PET imaging is presented, characterized, and tested in vitro and in vivo. Results The detector presented in this work stores and analyzes on-the-fly single and coincidence detected events. A sensitivity of 22.6 cps/(kBq/mL) and 1.7 cps/(kBq/mL) was obtained for single and coincidence events respectively. An energy resolution of 35% full-width-half-maximum (FWHM) at 511 keV and a minimum detectable activity of 0.30 ± 0.08 kBq/mL in single mode were obtained. The in vivo AIFs obtained with the detector show an excellent Pearson’s correlation (r = 0.996, p < 0.0001) with the ones obtained from well counter analysis of discrete blood samples. Moreover, in vitro experiments demonstrate the capability of the detector to apply the gamma spectroscopic analysis on a mixture of 68Ga and 18F and separate the individual signal emitted from each one. Conclusions Characterization and in vivo evaluation under realistic experimental conditions showed that the detector proposed in this work offers excellent sensibility and stability. The device also showed to successfully separate individual signals emitted from a mixture of radioisotopes. Therefore, the blood sample detector presented in this study allows fully automatic AIFs measurements during single- and multi-tracer PET studies.

scholarly journals Clinically Applicable Cyclotron-Produced Gallium-68 Gives High-Yield Radiolabeling of DOTA-Based Tracers

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1118
Author(s):  
Emma Jussing ◽  
Stefan Milton ◽  
Erik Samén ◽  
Mohammad Mahdi Moein ◽  
Lovisa Bylund ◽  
...  
Keyword(s):  
Metal Ion ◽  
Metal Content ◽  
Gamma Spectroscopy ◽  
Radiochemical Yield ◽  
High Yield ◽  
Automated Synthesis ◽  
Molar Activity ◽  
Icp Ms ◽  
Gallium 68 ◽  
Fe Impurities

By using solid targets in medical cyclotrons, it is possible to produce large amounts of 68GaCl3. Purification of Ga3+ from metal ion impurities is a critical step, as these metals compete with Ga3+ in the complexation with different chelators, which negatively affects the radiolabeling yields. In this work, we significantly lowered the level of iron (Fe) impurities by adding ascorbate in the purification, and the resulting 68GaCl3could be utilized for high-yield radiolabeling of clinically relevant DOTA-based tracers. 68GaCl3 was cyclotron-produced and purified with ascorbate added in the wash solutions through the UTEVA resins. The 68Ga eluate was analyzed for radionuclidic purity (RNP) by gamma spectroscopy, metal content by ICP-MS, and by titrations with the chelators DOTA, NOTA, and HBED. The 68GaCl3eluate was utilized for GMP-radiolabeling of the DOTA-based tracers DOTATOC and FAPI-46 using an automated synthesis module. DOTA chelator titrations gave an apparent molar activity (AMA) of 491 ± 204 GBq/µmol. GMP-compliant syntheses yielded up to 7 GBq/batch [68Ga]Ga-DOTATOC and [68Ga]Ga-FAPI-46 (radiochemical yield, RCY ~ 60%, corresponding to ten times higher compared to generator-based productions). Full quality control (QC) of 68Ga-labelled tracers showed radiochemically pure and stable products at least four hours from end-of-synthesis.

Flash ADC‐based digital LDO with non‐linear decoder and exponential‐ratio array

2019 ◽  
Vol 55 (10) ◽  
pp. 585-587 ◽  
Author(s):  
Zhendong Ding ◽  
Xinyu Xu ◽  
Haixin Song ◽  
Woogeun Rhee ◽  
Zhihua Wang
Keyword(s):  
Flash Adc ◽  
Non Linear
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