Influence of the Hydro/Fluorocarbon Chain Length on CMC and HLB of Surface-Active Nonionic Surfactants Containing Polyethylene Glycol Groups

2018 ◽  
Vol 55 (3) ◽  
pp. 246-251 ◽  
Author(s):  
Ali Khalfallah ◽  
Abdelkader Kriaa ◽  
Ahmed Hedhli
Keyword(s):  
Polyethylene Glycol ◽  
Chain Length ◽  
Nonionic Surfactants ◽  
Surface Active ◽  
Fluorocarbon Chain

The Impact of Bioconjugation on the Interfacial Activity of a Protein Biosurfactant

2018 ◽  
Author(s):  
Hossam H Tayeb ◽  
Marina Stienecker ◽  
Anton Middelberg ◽  
Frank Sainsbury
Keyword(s):  
Polyethylene Glycol ◽  
Colloidal Stability ◽  
Point Mutations ◽  
Pharmaceutical Formulations ◽  
Industrial Processes ◽  
Parent Molecule ◽  
Site Specific ◽  
Interfacial Activity ◽  
Surface Active ◽  
The Impact

Biosurfactants, are surface active molecules that can be produced by renewable, industrially scalable biologic processes. DAMP4, a designer biosurfactant, enables the modification of interfaces via genetic or chemical fusion to functional moieties. However, bioconjugation of addressable amines introduces heterogeneity that limits the precision of functionalization as well as the resolution of interfacial characterization. Here we designed DAMP4 variants with cysteine point mutations to allow for site-specific bioconjugation. The DAMP4 variants were shown to retain the structural stability and interfacial activity characteristic of the parent molecule, while permitting efficient and specific conjugation of polyethylene glycol (PEG). PEGylation results in a considerable reduction on the interfacial activity of both single and double mutants. Comparison of conjugates with one or two conjugation sites shows that both the number of conjugates as well as the mass of conjugated material impacts the interfacial activity of DAMP4. As a result, the ability of DAMP4 variants with multiple PEG conjugates to impart colloidal stability on peptide-stabilized emulsions is reduced. We suggest that this is due to constraints on the structure of amphiphilic helices at the interface. Specific and efficient bioconjugation permits the exploration and investigation of the interfacial properties of designer protein biosurfactants with molecular precision. Our findings should therefore inform the design and modification of biosurfactants for their increasing use in industrial processes, and nutritional and pharmaceutical formulations.

scholarly journals The effect of the polyethylene glycol chain length of a lipopolymer (DSPE-PEGn) on the properties of DPPC monolayers and bilayers

2021 ◽  
pp. 116529
Author(s):  
Magdalena Kowalska ◽  
Marcin Broniatowski ◽  
Marzena Mach ◽  
Łukasz Płachta ◽  
Paweł Wydro
Keyword(s):  
Polyethylene Glycol ◽  
Chain Length

Impact of Surface Active Ionic Liquids on the Cloud Points of Nonionic Surfactants and the Formation of Aqueous Micellar Two-Phase Systems

2017 ◽  
Vol 121 (37) ◽  
pp. 8742-8755 ◽  
Author(s):  
Filipa A. Vicente ◽  
Inês S. Cardoso ◽  
Tânia E. Sintra ◽  
Jesus Lemus ◽  
Eduardo F. Marques ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Nonionic Surfactants ◽  
Two Phase ◽  
Cloud Points ◽  
Surface Active ◽  
Phase Systems

Impact of the chain length on the biodistribution profiles of PEGylated iron oxide nanoparticles: a multimodal imaging study

2021 ◽  
Author(s):  
Dimitri Stanicki ◽  
Lionel Larbanoix ◽  
Sébastien Boutry ◽  
Thomas Vangijzegem ◽  
Indiana Ternad ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Iron Oxide ◽  
Chain Length ◽  
Iron Oxide Nanoparticles ◽  
Multimodal Imaging ◽  
Imaging Study ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Chain Lengths

Bimodal sub-5 nm superparamagnetic iron oxide nanoparticles (SPIO-5) coated with polyethylene glycol of different chain lengths (i.e. PEG-800, -2000 and -5000) have been prepared and characterized.

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