Effect of Non-electrolytes on the Cloud Point and Dye Solubilization of Antidepressant Drug, Clomipramine Hydrochloride

2010 ◽  
Vol 47 (6) ◽  
pp. 396-401 ◽  
Author(s):  
A. Z. Naqvi ◽  
M. D. A. Al-Ahmadi ◽  
M. Akram ◽  
Kabir-ud-Din
Keyword(s):  
Cloud Point ◽  
Antidepressant Drug ◽  
Dye Solubilization

CLOUD POINT AND DYE SOLUBILIZATION STUDIES OF AMPHIPHILIC DRUG SOLUTIONS: THE EFFECT OF ELECTROLYTES AND NONELECTROLYTES

2006 ◽  
Vol 193 (9) ◽  
pp. 1065-1074 ◽  
Author(s):  
Eui Jung Kim ◽  
Sunwook Kim ◽  
Ik-Keun Yoo ◽  
Jin Suk Chung ◽  
Jae Seong Kim ◽  
...  
Keyword(s):  
Cloud Point ◽  
Amphiphilic Drug ◽  
Dye Solubilization

Clouding behavior of antidepressant drug–additive system in ethylene glycol/glycerol–water mixed media and their thermodynamic parameters at cloud point

2018 ◽  
Vol 42 (6) ◽  
pp. 4402-4411 ◽  
Author(s):  
Ajmal Koya Pulikkal ◽  
Jackson Gurung
Keyword(s):  
Ethylene Glycol ◽  
Thermodynamic Parameters ◽  
Cloud Point ◽  
Antidepressant Drug ◽  
Mixed Media ◽  
Inorganic Salts ◽  
Glycerol Water ◽  
Additive System ◽  
Amphiphilic Drug ◽  
Amitriptyline Hydrochloride

The influence of ethylene glycol (EG)/glycerol(GL)–water mixed media on clouding action of an amphiphilic drug, amitriptyline hydrochloride was studied in presence and absence of inorganic salts in selected compositions of EG–WR and GL–WR mixed media.

Effect of Electrolytes on the Cloud Point and Dye Solubilization of Promazine Hydrochloride Solutions

2009 ◽  
Vol 30 (4) ◽  
pp. 439-444 ◽  
Author(s):  
Kabir-ud-Din ◽  
Mohd. D. A. Al-Ahmadi ◽  
Andleeb Z. Naqvi ◽  
Mohd. Akram
Keyword(s):  
Cloud Point ◽  
Dye Solubilization

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

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