scholarly journals Effect of Oral Administration of the IgE-suppressive Wild Yeast Strain Saccharomyces paradoxus P01 on the Development of Atopic Dermatitis-like Symptoms in NC/Nga Mice

2015 ◽  
Vol 21 (2) ◽  
pp. 223-230 ◽  
Author(s):  
Takeshi Kawahara ◽  
Daichi Nakayama ◽  
Katsumi Tanaka ◽  
Hisako Yasui
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Yeast Strain ◽  
Saccharomyces Paradoxus ◽  
Wild Yeast

scholarly journals Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/Dermatophagoides farinae Extract-Induced BALB/c Mice

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4409
Author(s):  
Jinjoo Kang ◽  
Soyoung Lee ◽  
Namkyung Kim ◽  
Hima Dhakal ◽  
Taeg-Kyu Kwon ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Diseases ◽  
Nuclear Translocation ◽  
Skin Lesions ◽  
Biologically Active ◽  
Therapeutic Effects ◽  
Dermatophagoides Farinae ◽  
Tnf Α ◽  
Ifn Γ

The extracts of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) have various therapeutic effects, including inflammation and allergy. In this study, gomisin M2 (GM2) was isolated from S. chinensis and its beneficial effects were assessed against atopic dermatitis (AD). We evaluated the therapeutic effects of GM2 on 2,4-dinitrochlorobenzene (DNCB) and Dermatophagoides farinae extract (DFE)-induced AD-like skin lesions with BALB/c mice ears and within the tumor necrosis factor (TNF)-α and interferon (IFN)-γ-stimulated keratinocytes. The oral administration of GM2 resulted in reduced epidermal and dermal thickness, infiltration of tissue eosinophils, mast cells, and helper T cells in AD-like lesions. GM2 suppressed the expression of IL-1β, IL-4, IL-5, IL-6, IL-12a, and TSLP in ear tissue and the expression of IFN-γ, IL-4, and IL-17A in auricular lymph nodes. GM2 also inhibited STAT1 and NF-κB phosphorylation in DNCB/DFE-induced AD-like lesions. The oral administration of GM2 reduced levels of IgE (DFE-specific and total) and IgG2a in the mice sera, as well as protein levels of IL-4, IL-6, and TSLP in ear tissues. In TNF-α/IFN-γ-stimulated keratinocytes, GM2 significantly inhibited IL-1β, IL-6, CXCL8, and CCL22 through the suppression of STAT1 phosphorylation and the nuclear translocation of NF-κB. Taken together, these results indicate that GM2 is a biologically active compound that exhibits inhibitory effects on skin inflammation and suggests that GM2 might serve as a remedy in inflammatory skin diseases, specifically on AD.

scholarly journals The Timing and Direction of Introgression Under the Multispecies Network Coalescent

Genetics ◽  
2019 ◽  
Vol 211 (3) ◽  
pp. 1059-1073 ◽  
Author(s):  
Mark S. Hibbins ◽  
Matthew W. Hahn
Keyword(s):  
Statistical Methods ◽  
Biological Process ◽  
Genomic Data ◽  
Hybrid Speciation ◽  
Saccharomyces Paradoxus ◽  
Genomic Signatures ◽  
Wild Yeast ◽  
Other Information ◽  
Homoploid Hybrid ◽  
New Statistics

Introgression is a pervasive biological process, and many statistical methods have been developed to infer its presence from genomic data. However, many of the consequences and genomic signatures of introgression remain unexplored from a methodological standpoint. Here, we develop a model for the timing and direction of introgression based on the multispecies network coalescent, and from it suggest new approaches for testing introgression hypotheses. We suggest two new statistics, D1 and D2, which can be used in conjunction with other information to test hypotheses relating to the timing and direction of introgression, respectively. D1 may find use in evaluating cases of homoploid hybrid speciation (HHS), while D2 provides a four-taxon test for polarizing introgression. Although analytical expectations for our statistics require a number of assumptions to be met, we show how simulations can be used to test hypotheses about introgression when these assumptions are violated. We apply the D1 statistic to genomic data from the wild yeast Saccharomyces paradoxus—a proposed example of HHS—demonstrating its use as a test of this model. These methods provide new and powerful ways to address questions relating to the timing and direction of introgression.

scholarly journals The spatial scale of genetic differentiation in a model organism: the wild yeast Saccharomyces paradoxus

2006 ◽  
Vol 361 (1475) ◽  
pp. 1941-1946 ◽  
Author(s):  
Vassiliki Koufopanou ◽  
Joseph Hughes ◽  
Graham Bell ◽  
Austin Burt
Keyword(s):  
Genetic Differentiation ◽  
Population Genomics ◽  
Model Organism ◽  
Physical Distance ◽  
Saccharomyces Paradoxus ◽  
Population Genetic Differentiation ◽  
Wild Yeast ◽  
Oak Trees ◽  
Eukaryotic Microbes ◽  
Well Differentiated

Little information is presently available on the factors promoting genetic divergence in eukaryotic microbes. We studied the spatial distribution of genetic variation in Saccharomyces paradoxus , the wild relative of Saccharomyces cerevisiae , from the scale of a few centimetres on individual oak trees to thousands of kilometres across different continents. Genealogical analysis of six loci shows that isolates from Europe form a single recombining population, and within this population genetic differentiation increases with physical distance. Between different continents, strains are more divergent and genealogically independent, indicating well-differentiated lineages that may be in the process of speciation. Such replicated populations will be useful for studies in population genomics.

scholarly journals Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis

2018 ◽  
Vol 154 (1) ◽  
pp. 37 ◽  
Author(s):  
Vicente Navarro-López ◽  
Ana Ramírez-Boscá ◽  
Daniel Ramón-Vidal ◽  
Beatriz Ruzafa-Costas ◽  
Salvador Genovés-Martínez ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Young Patients ◽  
Topical Steroids ◽  
Probiotic Strains

Oral administration of Uncariae rhynchophylla inhibits the development of DNFB-induced atopic dermatitis-like skin lesions via IFN-γ down-regulation in NC/Nga mice

2009 ◽  
Vol 122 (3) ◽  
pp. 567-572 ◽  
Author(s):  
Dong-Young Kim ◽  
Jung-A Jung ◽  
Tae-Ho Kim ◽  
Sang-Wan Seo ◽  
Sung-Ki Jung ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Lesions ◽  
Down Regulation ◽  
Ifn Γ

scholarly journals Enzymatic hydrolysis of cassava starch for production of bioethanol with a colombian wild yeast strain

2011 ◽  
Vol 22 (12) ◽  
pp. 2337-2343 ◽  
Author(s):  
Mónica I. Ruiz ◽  
Clara I. Sanchez ◽  
Rodrigo G. Torrres ◽  
Daniel R. Molina
Keyword(s):  
Enzymatic Hydrolysis ◽  
Yeast Strain ◽  
Cassava Starch ◽  
Wild Yeast ◽  
Hydrolysis Of
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