scholarly journals Usage of Digital D Chart Test as a Modification of Amsler Grid in Ophthalmology and Optometry

2020 ◽  
Vol 76 (4) ◽  
pp. 160-164
Author(s):  
Magdaléna Bočková ◽  
Petr Veselý ◽  
Pavel Beneš
Keyword(s):  
Visual Field ◽  
Quantitative Evaluation ◽  
Central Visual Field ◽  
Grid Deformation ◽  
Age Related ◽  
Significant Difference ◽  
Simple Detection ◽  
Important Symptom ◽  
Amsler Grid

Aims: Metamorphopsia is important symptom of macular disease. The most common simple detection method of metamorphopsia is Amsler grid. Usually it is used monocularly with best correction for near. Patient should evaluate grid deformation and describe position of the deformity. This method is based on qualitative principle. For quantitative evaluation we can use Software D Chart (Thomson Software Solution). This instrument enables evaluate degree and position of the metamorphopsia in central visual field. Our goal was to establish M-score values in group of young healthy subjects without correction (M-score natural), with cylindrical spectacle lens (M-score SL) and in group of patients with age related degeneration (M-score ARMD). Objects and Methods: We had 33 probands divided into 2 samples. The first sample contains 15 young probands with average age 23 years without any eye pathology. The second sample contains 18 patients with ARMD (7 with dry form and 11 with wet form). In our study we used software D Chart (Thomson Software Solution). This software was use in Acer PC with touchable screen. We note total M-score in right eye of all probands. Level for statistic evaluation was set on p = 0.05. Results: Natural M-score values for young probands was: median 0, minimum 0, maximum 2.3. With cylindrical lens we got these values: median 25.2, minimum 3.6, maximum 41.6. In second sample with probands suffer from ARMD we got these values: median 0.8, minimum 0, maximum 29.4. Wilcoxon non-parametric test was used for statistical evaluation. We proved statistically significant difference between all variables. M-score natural vs. M-score SL showed p < 0.001, M-score natural vs. M-score ARMD showed p = 0.04 and M-score SL vs. M-score ARMD showed p < 0.001. Conclusion: Our study showed statistically significant differences between variable M-score natural, M-score SL and M-score ARMD. We found that printed Amsler grid as well as its digital modification D Chart are suitable for determining metamorphopsia in central visual field. The main advantage of D Chart is quantitative evaluation of the test with M-score and digital registration of retinal changes during patient´s follow up.

Circular vection in patients with age-related macular degeneration

1999 ◽  
Vol 9 (4) ◽  
pp. 287-291
Author(s):  
Hiroaki Fushiki ◽  
Satoru Takata ◽  
Yasunori Nagaki ◽  
Yukio Watanabe
Keyword(s):  
Visual Field ◽  
Macular Degeneration ◽  
Matched Control ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Central Visual Field ◽  
Matched Control Group ◽  
Circular Vection ◽  
Age Related ◽  
Significant Difference

We have used optokinetic stimulation in patients with unilateral age-related macular degeneration (AMD) and central scotoma to investigate the possible contribution of the central visual field to circular vection (CV). Six patients aged 42–73 years with unilateral AMD and an aged-matched control group of nine elderly adults aged 47–75 years were examined. Monocular visual field defects were verified with the Goldmann perimeter by kinetic perimetry. The device used to induce CV was a random dot pattern projected onto a hemispherical dome with a radius of 75 cm. The pattern was rotated horizontally at a constant acceleration of 1 deg/s 2 . Monocular stimuli were randomly repeated two to three times in both temporal-nasal (T-N) and nasal-temporal (N-T) directions. The latency of onset of CV was measured for each stimulus presentation. In the age-matched control group the CV latencies varied from 4.2 to 72.0 s. In each case, however, the CV latencies were stable. No significant differences in CV latencies were found between right and left eyes in both stimulus directions ( p > 0.05). In patients with AMD, no statistically significant difference in CV latency was found between the affected and unaffected eyes ( p > 0.05). Marked central visual field loss in AMD does not significantly impair peripherally induced CV. Our results are compatible with the hypothesis that the peripheral retina dominates CV.

Validating the usefulness of sectorwise regression of visual field in the central 10°

2021 ◽  
pp. bjophthalmol-2020-317391
Author(s):  
Takashi Omoto ◽  
Hiroshi Murata ◽  
Yuri Fujino ◽  
Masato Matsuura ◽  
Takehiro Yamashita ◽  
...  
Keyword(s):  
Visual Field ◽  
Mean Absolute Error ◽  
Open Angle Glaucoma ◽  
Absolute Error ◽  
Open Angle ◽  
Clustering Method ◽  
Significant Difference ◽  
The Mean ◽  
Test Points

AimTo evaluate the usefulness of the application of the clustering method to the trend analysis (sectorwise regression) in comparison with the pointwise linear regression (PLR).MethodsThis study included 153 eyes of 101 patients with open-angle glaucoma. With PLR, the total deviation (TD) values of the 10th visual field (VF) were predicted using the shorter VF sequences (from first 3 to 9) by extrapolating TD values against time in a pointwise manner. Then, 68 test points were stratified into 29 sectors. In each sector, the mean of TD values was calculated and allocated to all test points belonging to the sector. Subsequently, the TD values of the 10th VF were predicted by extrapolating the allocated TD value against time in a pointwise manner. Similar analyses were conducted to predict the 11th–16th VFs using the first 10 VFs.ResultsWhen predicting the 10th VF using the shorter sequences, the mean absolute error (MAE) values were significantly smaller in the sectorwise regression than in PLR. When predicting from the 11th and 16th VFs using the first 10 VFs, the MAE values were significantly larger in the sectorwise regression than in PLR when predicting the 11th VF; however, no significant difference was observed with other VF predictions.ConclusionAccurate prediction was achieved using the sectorwise regression, in particular when a small number of VFs were used in the prediction. The accuracy of the sectorwise regression was not hampered in longer follow-up compared with PLR.

scholarly journals Real-World Results of Aflibercept versus Ranibizumab for the Treatment of Exudative AMD Using a Fixed Regimen

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Joana Providência ◽  
Tiago M. Rodrigues ◽  
Mariana Oliveira ◽  
João Bernardes ◽  
João Pedro Marques ◽  
...  
Keyword(s):  
Real World ◽  
Age Related Macular Degeneration ◽  
Treatment Protocols ◽  
Corrected Visual Acuity ◽  
Age Related ◽  
Significant Difference ◽  
Clinical Practice Setting ◽  
The Mean ◽  
Endothelial Growth Factors

Intravitreal injections of antivascular endothelial growth factors have been considered a milestone in the treatment of neovascular age-related macular degeneration (nAMD). However, the increasing incidence of AMD and the burden of visits and injections overcharge both the patient and the healthcare systems. Real-world solutions depend on treatment protocols aimed at optimizing the number of clinical visits while guaranteeing good functional outcomes. We performed a retrospective analysis of 72 eyes from 63 naïve patients diagnosed with nAMD that underwent a fixed intravitreal protocol consisting of bimonthly injections after a three-month loading dose, with either Aflibercept or Ranibizumab (no predefined criteria for treatment selection). Best corrected visual acuity (BCVA) and optical coherence tomography were analyzed at baseline and during follow-up clinical visits (months 3, 6, 12, and 18). From the included participants, 42 followed a fixed regimen with Aflibercept and 30 with Ranibizumab. At the 12-month visit, there was not a statistically significant difference in the mean change of BCVA between the two groups (p=0.121); however, the mean difference in the central retinal thickness was significantly superior in the Aflibercept group (-142.2 versus -51.5, p=0.011). The described fixed regimen seems to be efficient in the treatment of nAMD in a clinical practice setting.

scholarly journals Inhibition of epidural fibrosis after microendoscopic discectomy with topical application of mitomycin C: a randomized, controlled, double-blind trial

2013 ◽  
Vol 18 (5) ◽  
pp. 421-427 ◽  
Author(s):  
Lei Liu ◽  
Tao Sui ◽  
Xin Hong ◽  
Xiaotao Wu ◽  
Xiaojian Cao
Keyword(s):  
Adverse Effects ◽  
Mitomycin C ◽  
Quantitative Evaluation ◽  
Saline Group ◽  
Physical Symptoms ◽  
Grading System ◽  
Epidural Fibrosis ◽  
Significant Difference ◽  
Microendoscopic Discectomy

Object The authors conducted a study to evaluate the effects and the safety of locally applied mitomycin C (MMC) on epidural fibrosis after microendoscopic discectomy (MED). Methods Seventy-five patients undergoing single-level unilateral MED for lumbar disc herniation were randomly assigned to receive cotton wool impregnated with either 0.5 mg/ml MMC or saline applied at the site of discectomy for 5 minutes. Outcome measures included degrees of pain severity, functional disability, physical symptoms, and quantitative evaluation of postoperative epidural fibrosis shown on follow-up lumbar contrast-enhanced MRI. Results Sixty-two patients completed the follow-up. Neither serious drug adverse effects nor clinically significant laboratory adverse effects were observed. Patients in both groups showed similar clinical recoveries postoperatively. A statistically significant difference (p < 0.05) between the 2 treatments was shown in a quantitative evaluation of postoperative MRI-documented epidural fibrosis in the MMC group and the saline group using a modified grading system. The mean cross-sectional areas of epidural fibrosis were 7.32–70.06 mm2 in the MMC group and 22.94–90.48 mm2 in the saline group. The epidural fibrosis index ranged from 0.0296 to 0.3267 in the MMC group and from 0.1191 to 0.3483 in the saline group. A significant difference was also observed using the Ross grading system to evaluate postoperative MR images. Conclusions Although no benefit was observed clinically, the authors observed a notable reduction of epidural fibrosis after MED radiologically, with 0.5 mg/ml MMC locally applied and no clinical side effects. Clinical trial registration no.: ChiCTR-TRC-10001079 (http://www.chictr.org/cn/proj/show.aspx?proj=326).

Implantation of the First IMT Macular Lens in Age-Related Macular Degeneration (Literature Review)

2019 ◽  
Vol 4 (4) ◽  
pp. 56-60
Author(s):  
M. M. Bikbov ◽  
O. I. Orenburkina ◽  
A. E. Babushkin
Keyword(s):  
Visual Field ◽  
Macular Degeneration ◽  
Peripheral Vision ◽  
Age Related Macular Degeneration ◽  
Central Vision ◽  
Central Visual Field ◽  
Visual Rehabilitation ◽  
Age Related ◽  
Terminal Form ◽  
Special Programs

This review presents the characteristics and results of clinical studies of patients with age-related macular degeneration implanted with the developed for this purpose first macular IOL – intraocular macular telescope (IMT). This lens was designed specifically for patients with the most severe or terminal form of age-related macular degeneration and is designed for monocular implantation to provide central vision while maintaining peripheral vision of the paired eye, which is important for maintaining the balance and orientation of patients. This device allows patients to see both in dynamic and static situations in the near, intermediate and far ranges. The disadvantages of this lens are a decrease in the visual field and depth of focus (which excludes its bilateral implantation), the need for a large (10–12 mm) incision for implantation, which can cause an increase in corneal astigmatism and the risk of complications, in particular, the pupillary block with an increase in intraocular pressure. There are also difficulties in the study of the fundus after its implantation to assess the small changes in the macula or to identify possible postoperative complications after cataract surgery (macular oedema, etc.). Also after the implantation of this lens, there is need for special programs of visual rehabilitation. The patient’s commitment to the rehabilitation measures for the adaptation of the central visual field of the operated eye with the peripheral vision of the second eye is crucial for success of the IMT macular telescope implantation procedure.

Efficacy of the Amsler Grid Test in Evaluating Glaucomatous Central Visual Field Defects

Ophthalmology ◽  
2016 ◽  
Vol 123 (4) ◽  
pp. 737-743 ◽  
Author(s):  
Daniel Su ◽  
Andrew Greenberg ◽  
Joseph L. Simonson ◽  
Christopher C. Teng ◽  
Jeffrey M. Liebmann ◽  
...  
Keyword(s):  
Visual Field ◽  
Visual Field Defects ◽  
Central Visual Field ◽  
Amsler Grid ◽  
Field Defects ◽  
Grid Test

scholarly journals Effectiveness of measuring the central field with the Berkeley field test

2014 ◽  
Vol 6 (2) ◽  
pp. 170-176
Author(s):  
Sanjeeb K Mishra ◽  
Gauri S Shrestha ◽  
Hiral Korani
Keyword(s):  
Visual Field ◽  
Field Test ◽  
Predictive Value ◽  
Scoring System ◽  
Central Field ◽  
Central Visual Field ◽  
Near Vision ◽  
Amsler Grid ◽  
Sensitivity Specificity ◽  
Grid Test

Introduction: There are several limitations of the Amsler chart as a screening tool due to its low sensitivity and high false-negative results. The Berkeley central visual field test (BCFT), which is a simple power-point presentation of a 50-point scoring system for the central 10-degree of the visual field, was devised as an alternative to the Amsler chart.Objectives: To compare the efficacy of measuring the central visual field using the Berkeley central field test (BCFT) and the Amsler grid test.Materials and methods: In a comparative and validity study, 30 subjects with maculopathy and 35 controls were recruited. The maculopathy subjects with the best corrected visual acuity of 20/200 or better and 2.5M for distant and near vision respectively, were included. All the subjects under went a complete eye examination where visual assessment was done using the distant and near vision Log MAR Chart. The subjects were assessed with the Amsler chart-II at a distance of 30 cm. The BCFT was used as a 50- point scoring system. The effectiveness of BCFT was compared with that of the Amsler grid regarding the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV).  Results: Out of 65 subjects, 30 subjects had maculopathy and 35 were normal. The mean age of the 65 subjects was 49.8±9.1 years. Of the 30 subjects with maculopathy, the majority (54%) had age- related macular degeneration. The sensitivity, specificity, PPV and NPV of the Amsler grid test were found to be 80%, 100%, 100% and 87%, respectively, whereas those of the BCFT were 71%, 99%, 98% and 82% (p=0.37). Conclusion: The BCFT test was as good as the Amsler grid test at detecting the presence of maculopathy.DOI: http://dx.doi.org/10.3126/nepjoph.v6i2.11701Nepal J Ophthalmol 2014; 6 (12): 170-176 

057 Age-related changes in sleep impact learning-related functional connectivity in the cortico-striatal-hippocampal system

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A24-A24
Author(s):  
Dylan Smith ◽  
Zhuo Fang ◽  
Julie Carrier ◽  
Julien Doyon ◽  
Stuart Fogel
Keyword(s):  
Opposite Effect ◽  
Brain Activity ◽  
Functional Communication ◽  
Older Individuals ◽  
Younger Adults ◽  
Age Related ◽  
Motor Network ◽  
Significant Difference ◽  
Older Subjects

Abstract Introduction Older adults do not consolidate newly learned motor sequences with the same efficiency compared to younger adults, and there is evidence that enhanced consolidation by sleep is also impaired with age. It is known that brain activity in the hippocampal-cortical-striatal network is important for off-line consolidation of motor-sequences, however, the intricacies of how communication within this network is altered by sleep in order to facilitate consolidation is not known. Methods In this study, 37 young and 49 older individuals underwent resting state MRI before training on a MSL task, as well as after training, and then once again, after either a nap or a period of awake rest. Results Preliminary analysis showed a significant difference in functional communication (FC) in the hippocampal-cortical-striatal network, with younger subjects showing increased FC compared to younger individuals. Follow-up analyses revealed this effect was driven by younger subjects who showed an increase in FC between striatum and motor cortices, as well as older subjects who showed decreased FC between hippocampus, striatum, and precuneus. Therefore, an opposite effect of sleep was observed in younger vs. older participants, where young participants primarily showed increased communication in the striatal-motor network and older participants showed decrease in key nodes of the default mode network. Conclusion This shows that changes to sleeps’ ability to optimize functional communication may disrupt sleep-enhanced MSL consolidation in old age. Support (if any) Canadian Institutes of Health Research

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