Basal laminar drusen and soft drusen have similar glycan composition

2010 ◽  
Vol 45 (3) ◽  
pp. 297-299 ◽  
Author(s):  
Yvonne B. D’souza ◽  
Carolyn J.P. Jones ◽  
Colin D. Short ◽  
Richard E. Bonshek
Keyword(s):  
Soft Drusen ◽  
Basal Laminar Drusen

scholarly journals Clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Young Ho Kim ◽  
Boram Lee ◽  
Edward Kang ◽  
Jaeryung Oh
Keyword(s):  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Soft Drusen ◽  
Pachychoroid Neovasculopathy ◽  
The Common ◽  
Common Pathogenesis ◽  
Clustering Pattern ◽  
Normal Controls

AbstractChoroidal changes have been suggested to be involved in the pathophysiology of both age-related macular degeneration (AMD) and pachychoroid spectrum diseases (PSD). To find out the choroidal characteristics of each disease groups, various groups of AMD and PSD were classified into several clusters according to choroidal profiles based on subfoveal choroidal thickness (CT), peripapillary CT, the ratio of subfoveal CT to peripapillary CT and age. We retrospectively analyzed 661 eyes, including 190 normal controls and 471 with AMD or PSDs. In the AMD groups, eyes with soft drusen or reticular pseudodrusen were belonged to the same cluster as those with classic exudative AMD (all p < 0.001). However, eyes with pachydrusen were not clustered with eyes from other AMD groups; instead, they were classified in the same cluster as eyes from the PSD group (all p < 0.001). In the PSD group, eyes with pachychoroid neovasculopathy were grouped in the same cluster of those with polypoidal choroidal vasculopathy (p < 0.001). The cluster analysis based on the CT profiles, including subfoveal CT, peripapillary CT, and their ratio, revealed a clustering pattern of eyes with AMD and PSDs. These findings support the suggestion that pachydrusen has the common pathogenesis as PSD.

Origins of Ghost Drusen: A follow-up Analysis

2017 ◽  
Vol 1 (1) ◽  
pp. oapoc.0000011
Author(s):  
Caroline Bottin ◽  
Olivia Zambrowski ◽  
Giuseppe Querques ◽  
Salomon Yves Cohen ◽  
Mayer Srour ◽  
...  
Keyword(s):  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Geographic Atrophy ◽  
Primary Lesion ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Soft Drusen ◽  
Initial Lesions ◽  
Sd Oct

Purpose Ghost drusen (GD) are pyramidal or dome-shaped retinal pigment epithelium elevations observed in some geographic atrophy (GA) areas in the context of age-related macular degeneration (AMD). The purpose was to investigate the first morphologic features preceding GD on spectral-domain optical coherence tomography (SD-OCT) on patients with GA associated with AMD. Methods A retrospective observational study was performed on a series of patients with GA that had at least 3 years of follow-up. Using the follow-up tool of SD-OCT, we tracked the initial lesions that could lead to GD. Results Among 442 patients with GA, 37 had well defined GD (8%). We included the 17/37 patients (31 eyes) with at least 3 years of follow-up for analysis, which led to a total of 582 counted GD. Most GD were already present at the first visit, and remained stable. However, on 13 of the 582 analyzed GD (2.2%), soft drusen were shown as the initial lesion, which progressively turned into GD. Conclusions GD were observed in less than 10% of eyes with GA. None of the ghost drusen turned into another shaped lesion, suggesting that GD is a possible final stage of evolution. In a few cases, large drusen were shown as the primary lesion that progressed into GD.

Colour contrast sensitivity in patients with soft drusen, an early stage of ARM

1995 ◽  
Vol 90 (4) ◽  
pp. 377-386 ◽  
Author(s):  
Christina Frennesson ◽  
Ulla L. Nilsson ◽  
Sven Erik G. Nilsson
Keyword(s):  
Contrast Sensitivity ◽  
Early Stage ◽  
Colour Contrast ◽  
Soft Drusen

Serum levels of antioxidant agents in patients with hard and soft drusen

1992 ◽  
Vol 55 ◽  
pp. 253
Author(s):  
G. Staurenghi ◽  
F. Bottoni ◽  
M. Aschero ◽  
C. Lonati ◽  
W. Schuep ◽  
...  
Keyword(s):  
Serum Levels ◽  
Antioxidant Agents ◽  
Soft Drusen

Prevalence of age-related macular degeneration associated genetic risk factors and 4-year progression data in the Irish population

2018 ◽  
Vol 102 (12) ◽  
pp. 1691-1695 ◽  
Author(s):  
Emma Connolly ◽  
Maedbh Rhatigan ◽  
Aisling M O’Halloran ◽  
Katherine Alyson Muldrew ◽  
Usha Chakravarthy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Macular Degeneration ◽  
Disease Progression ◽  
Genetic Risk ◽  
Risk Allele ◽  
Genetic Risk Factors ◽  
Age Related Macular Degeneration ◽  
Complement Factor ◽  
Age Related ◽  
Soft Drusen

Background/aimsAge-related macular degeneration (AMD) is estimated to affect 196 million people >50 years old globally. Prevalence of AMD-associated genetic risk factors and rate of disease progression are unknown in Ireland.MethodsPrevalence of AMD-associated genetic risk variants, complement factor H (CFH) rs1061170, age-related maculopathy susceptibility 2 (ARMS2) rs10490924, component 3 (C3) rs2230199, complement factor B (CFB) rs641153 and superkiller viralicidic activity 2-like (SKIV2L) rs429608 and 4-year progression data in a population-representative cohort (The Irish Longitudinal study on Ageing (TILDA)) were assessed. 4473 participants ≥50 years were assessed. 4173 had no disease n=1843; 44% male and n=2330; 56% female, mean age 60±9.0, 300 had AMD n=136; 45% male and n=164; 55% female, mean age 64±9.0. A 4-year follow-up was undertaken with 66% of AMD cases attending. Progression and regression from early to late AMD were measured. Genetic association as indicators of disease and as predictors of progression were assessed by multinomial logistic regression.ResultsOlder age and the presence of CFH and ARMS2 risk alleles are two main risk factors associated with the prevalence of AMD in the TILDA cohort. 23% progressed to a higher grade of AMD. Carriers of CFH risk allele showed a strong association for disease progression. Heterozygosity for ARMS2 risk allele predicted progression to late AMD. 75% of those who progressed from early to late disease had soft drusen and hyperpigmentation at baseline.ConclusionsThe prevalence of risk-associated genes and 4-year progression rates of AMD in this Ireland cohort are comparable with other Caucasian populations. CFH Y402H is associated with disease progression, with soft drusen and hyperpigmentation as high-risk features.

Abundance and multimodal visibility of soft drusen in early age-related macular degeneration

Retina ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ling Chen ◽  
Jeffrey D. Messinger ◽  
Kenneth R. Sloan ◽  
Jessica Wong ◽  
Austin Roorda ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Early Age ◽  
Age Related ◽  
Soft Drusen

scholarly journals Visual function and course of basal laminar drusen combined with vitelliform macular detachment.

1994 ◽  
Vol 78 (6) ◽  
pp. 437-440 ◽  
Author(s):  
S Y Cohen ◽  
I Meunier ◽  
G Soubrane ◽  
A Glacet-Bernard ◽  
G J Coscas
Keyword(s):  
Visual Function ◽  
Macular Detachment ◽  
Basal Laminar Drusen

LASER PHOTOCOAGULATION FOR MACULAR SOFT DRUSEN

Retina ◽  
1997 ◽  
Vol 17 (5) ◽  
pp. 378-384 ◽  
Author(s):  
MARTA S. FIGUEROA ◽  
ANGEL REGUERAS ◽  
JOSEFINA BERTRAND ◽  
MARIA JESUS APARICIO ◽  
MAR G. MANRIQUE
Keyword(s):  
Laser Photocoagulation ◽  
Soft Drusen
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