Stem cells: a source for neuron repair in retinal disease

2007 ◽  
Vol 42 (3) ◽  
pp. 442-446 ◽  
Author(s):  
Valerie A. Wallace
Keyword(s):  
Stem Cells ◽  
Retinal Disease

Pluripotent human stem cells for the treatment of retinal disease

2011 ◽  
Vol 227 (2) ◽  
pp. 457-466 ◽  
Author(s):  
Teisha J. Rowland ◽  
David E. Buchholz ◽  
Dennis O. Clegg
Keyword(s):  
Stem Cells ◽  
Retinal Disease ◽  
Human Stem Cells

Applications of Stem Cells in Cancer Therapy: A Literature Based Studies

2020 ◽  
Vol 6 (2) ◽  
pp. 30
Author(s):  
Sara Javed ◽  
Fatima Ali ◽  
Nadia Wajid
Keyword(s):  
Stem Cells ◽  
Cancer Therapy ◽  
Cancer Progression ◽  
Cell Biology ◽  
Retinal Disease ◽  
Age Related Macular Degeneration ◽  
Stem Cell Biology ◽  
Asymmetric Cell Divisions ◽  
Lineage Differentiation ◽  
Age Related

Stem cells, are extraordinary kind of cells having unique ability of self-renewal, lineage differentiation and regeneration of damaged organ or parts of body. Stem cells experience asymmetric cell divisions, bringing forth two cells from each cell, one cell is alike to SCs in stemnessess whereas, other is differentiated into various lineage. These cells have been known for decades for their highest regenerative potential but their clinical applications remain delayed due to several unknown mechanisms of their actions. With the discovery of Cancer Stem Cells, it was described that understanding the stem cell biology is important for a proper way of cancer cure. Stem cells are successfully being transplanted in several clinical trials to treat the retinal disease, visual disorders including retinitis pigmentosa, Stargardt's disease, wound healing, skin regeneration and age related macular degeneration. Their role in cancer progression is the hot debate of research by cell biologists as understanding their role will help to remove the hurdles in cancer therapy.

scholarly journals Stem cells for investigation and treatment of inherited retinal disease

2014 ◽  
Vol 23 (R1) ◽  
pp. R9-R16 ◽  
Author(s):  
B. A. Tucker ◽  
R. F. Mullins ◽  
E. M. Stone
Keyword(s):  
Stem Cells ◽  
Retinal Disease ◽  
Inherited Retinal Disease

scholarly journals Optic Vesicle-like Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment

Stem Cells ◽  
2011 ◽  
Vol 29 (8) ◽  
pp. 1206-1218 ◽  
Author(s):  
Jason S. Meyer ◽  
Sara E. Howden ◽  
Kyle A. Wallace ◽  
Amelia D. Verhoeven ◽  
Lynda S. Wright ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Retinal Disease ◽  
Human Pluripotent Stem Cells ◽  
Optic Vesicle ◽  
Disease Treatment

scholarly journals Using human induced pluripotent stem cells to treat retinal disease

2013 ◽  
Vol 37 ◽  
pp. 163-181 ◽  
Author(s):  
S. Borooah ◽  
M.J. Phillips ◽  
B. Bilican ◽  
A.F. Wright ◽  
I. Wilmut ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Retinal Disease ◽  
Induced Pluripotent

scholarly journals Interaction Between Mesenchymal Stem Cells and Retinal Degenerative Microenvironment

2021 ◽  
Vol 14 ◽  
Author(s):  
Yu Lin ◽  
Xiang Ren ◽  
Yongjiang Chen ◽  
Danian Chen
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Vision Loss ◽  
Therapeutic Potential ◽  
Clinical Stage ◽  
Retinal Disease ◽  
Tumor Formation ◽  
Cell Based Therapy ◽  
Retinal Degenerative Diseases ◽  
Stromal Stem Cells

Retinal degenerative diseases (RDDs) are a group of diseases contributing to irreversible vision loss with yet limited therapies. Stem cell-based therapy is a promising novel therapeutic approach in RDD treatment. Mesenchymal stromal/stem cells (MSCs) have emerged as a leading cell source due to their neurotrophic and immunomodulatory capabilities, limited ethical concerns, and low risk of tumor formation. Several pre-clinical studies have shown that MSCs have the potential to delay retinal degeneration, and recent clinical trials have demonstrated promising safety profiles for the application of MSCs in retinal disease. However, some of the clinical-stage MSC therapies have been unable to meet primary efficacy end points, and severe side effects were reported in some retinal “stem cell” clinics. In this review, we provide an update of the interaction between MSCs and the RDD microenvironment and discuss how to balance the therapeutic potential and safety concerns of MSCs' ocular application.

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