Vitreopapillary traction: Cost-effective diagnosis by optical coherence tomography

2006 ◽  
Vol 41 (6) ◽  
pp. 763-765 ◽  
Author(s):  
Shannon Cabrera ◽  
Allen Katz ◽  
Eyal Margalit
Keyword(s):  
Optical Coherence Tomography ◽  
Cost Effective ◽  
Optical Coherence ◽  
Effective Diagnosis

scholarly journals Expert-level Automated Biomarker Identification in Optical Coherence Tomography Scans

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Thomas Kurmann ◽  
Siqing Yu ◽  
Pablo Márquez-Neila ◽  
Andreas Ebneter ◽  
Martin Zinkernagel ◽  
...  
Keyword(s):  
Machine Learning ◽  
Optical Coherence Tomography ◽  
Critical Role ◽  
Cost Effective ◽  
Automated Analysis ◽  
Machine Learning Algorithms ◽  
Three Dimensions ◽  
Optical Coherence ◽  
Clinical Routine ◽  
Wide Range

Abstract In ophthalmology, retinal biological markers, or biomarkers, play a critical role in the management of chronic eye conditions and in the development of new therapeutics. While many imaging technologies used today can visualize these, Optical Coherence Tomography (OCT) is often the tool of choice due to its ability to image retinal structures in three dimensions at micrometer resolution. But with widespread use in clinical routine, and growing prevalence in chronic retinal conditions, the quantity of scans acquired worldwide is surpassing the capacity of retinal specialists to inspect these in meaningful ways. Instead, automated analysis of scans using machine learning algorithms provide a cost effective and reliable alternative to assist ophthalmologists in clinical routine and research. We present a machine learning method capable of consistently identifying a wide range of common retinal biomarkers from OCT scans. Our approach avoids the need for costly segmentation annotations and allows scans to be characterized by biomarker distributions. These can then be used to classify scans based on their underlying pathology in a device-independent way.

scholarly journals Fiber optically integrated cost-effective spectrometer for optical coherence tomography

2014 ◽  
Author(s):  
Stefan Remund ◽  
Anke Bossen ◽  
Xianfeng Chen ◽  
Ling Wang ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cost Effective ◽  
Optical Coherence ◽  
Integrated Cost

scholarly journals Cost-effective optical coherence tomography spectrometer based on a tilted fiber Bragg grating

2014 ◽  
Author(s):  
Stefan Remund ◽  
Anke Bossen ◽  
Xianfeng Chen ◽  
Ling Wang ◽  
Adedotun Adebayo ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fiber Bragg Grating ◽  
Cost Effective ◽  
Bragg Grating ◽  
Optical Coherence

scholarly journals Complete Removal of Arbitrarily Strong and Arbitrarily Located Auto Correlation Artifacts in Spectral Domain Optical Coherence Tomography: Demonstration of an Efficient and Cost Effective Technique

2020 ◽  
Author(s):  
Hari Nandakumar ◽  
SatyaPrasanna Mallick ◽  
Shailesh Srivastava
Keyword(s):  
Optical Coherence Tomography ◽  
Cost Effective ◽  
Complete Removal ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Effective Technique ◽  
Spectral Domain Oct ◽  
Auto Correlation ◽  
Cost Effective Technique ◽  
Sd Oct

The proof-of-principle demonstration of a simple, yet effective method of autocorrelation artifact removal for optical coherence tomography (OCT) is presented using a custom-designed parallel spectral-domain OCT (SD-OCT) instrument. Our real-time method is based on time-averaged sampling of a sinusoidal phase modulation in the reference arm. Unlike other existing methods, our technique can completely eliminate arbitrarily located, arbitrarily strong autocorrelation artifacts.

Cost effective all-fiber autocorrelator for optical coherence tomography imaging

2005 ◽  
Author(s):  
Jeff Bush ◽  
Felix Feldchtein ◽  
Grigory Gelikonov ◽  
Valentin Gelikonov ◽  
Sergey Piyevsky
Keyword(s):  
Optical Coherence Tomography ◽  
Cost Effective ◽  
Optical Coherence ◽  
Tomography Imaging ◽  
Optical Coherence Tomography Imaging

scholarly journals Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation

2014 ◽  
Vol 18 (69) ◽  
pp. 1-254 ◽  
Author(s):  
Graham Mowatt ◽  
Rodolfo Hernández ◽  
Mayret Castillo ◽  
Noemi Lois ◽  
Andrew Elders ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diagnostic Accuracy ◽  
Macular Degeneration ◽  
High Sensitivity ◽  
Cost Effective ◽  
Health Technology ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Age Related ◽  
Sd Oct

BackgroundAge-related macular degeneration is the most common cause of sight impairment in the UK. In neovascular age-related macular degeneration (nAMD), vision worsens rapidly (over weeks) due to abnormal blood vessels developing that leak fluid and blood at the macula.ObjectivesTo determine the optimal role of optical coherence tomography (OCT) in diagnosing people newly presenting with suspected nAMD and monitoring those previously diagnosed with the disease.Data sourcesDatabases searched: MEDLINE (1946 to March 2013), MEDLINE In-Process & Other Non-Indexed Citations (March 2013), EMBASE (1988 to March 2013), Biosciences Information Service (1995 to March 2013), Science Citation Index (1995 to March 2013), The Cochrane Library (Issue 2 2013), Database of Abstracts of Reviews of Effects (inception to March 2013), Medion (inception to March 2013), Health Technology Assessment database (inception to March 2013).Review methodsTypes of studies: direct/indirect studies reporting diagnostic outcomes. Index test: time domain optical coherence tomography (TD-OCT) or spectral domain optical coherence tomography (SD-OCT). Comparators: clinical evaluation, visual acuity, Amsler grid, colour fundus photographs, infrared reflectance, red-free images/blue reflectance, fundus autofluorescence imaging, indocyanine green angiography, preferential hyperacuity perimetry, microperimetry. Reference standard: fundus fluorescein angiography (FFA). Risk of bias was assessed using quality assessment of diagnostic accuracy studies, version 2. Meta-analysis models were fitted using hierarchical summary receiver operating characteristic curves. A Markov model was developed (65-year-old cohort, nAMD prevalence 70%), with nine strategies for diagnosis and/or monitoring, and cost–utility analysis conducted. NHS and Personal Social Services perspective was adopted. Costs (2011/12 prices) and quality-adjusted life-years (QALYs) were discounted (3.5%). Deterministic and probabilistic sensitivity analyses were performed.ResultsIn pooled estimates of diagnostic studies (all TD-OCT), sensitivity and specificity [95% confidence interval (CI)] was 88% (46% to 98%) and 78% (64% to 88%) respectively. For monitoring, the pooled sensitivity and specificity (95% CI) was 85% (72% to 93%) and 48% (30% to 67%) respectively. The FFA for diagnosis and nurse-technician-led monitoring strategy had the lowest cost (£39,769; QALYs 10.473) and dominated all others except FFA for diagnosis and ophthalmologist-led monitoring (£44,649; QALYs 10.575; incremental cost-effectiveness ratio £47,768). The least costly strategy had a 46.4% probability of being cost-effective at £30,000 willingness-to-pay threshold.LimitationsVery few studies provided sufficient information for inclusion in meta-analyses. Only a few studies reported other tests; for some tests no studies were identified. The modelling was hampered by a lack of data on the diagnostic accuracy of strategies involving several tests.ConclusionsBased on a small body of evidence of variable quality, OCT had high sensitivity and moderate specificity for diagnosis, and relatively high sensitivity but low specificity for monitoring. Strategies involving OCT alone for diagnosis and/or monitoring were unlikely to be cost-effective. Further research is required on (i) the performance of SD-OCT compared with FFA, especially for monitoring but also for diagnosis; (ii) the performance of strategies involving combinations/sequences of tests, for diagnosis and monitoring; (iii) the likelihood of active and inactive nAMD becoming inactive or active respectively; and (iv) assessment of treatment-associated utility weights (e.g. decrements), through a preference-based study.Study registrationThis study is registered as PROSPERO CRD42012001930.FundingThe National Institute for Health Research Health Technology Assessment programme.

1086: Cystoscopic Optical Coherence Tomography in Diagnosis and Management of Clinical Bladder Tumors

2007 ◽  
Vol 177 (4S) ◽  
pp. 358-359 ◽  
Author(s):  
Christopher S. Lee ◽  
Alek Mishail ◽  
Jason M. Kim ◽  
Alexander Kirshenbaum ◽  
Howard L. Adler ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Bladder Tumors ◽  
Diagnosis And Management

1227: Optical Coherence Tomography-Guided Surgery of Bladder Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 395-395
Author(s):  
Nancy J. Tresser ◽  
Elena V. Zagaynova ◽  
Olga S. Streltsova ◽  
Natalia D. Gladkova ◽  
Vladislav A. Kamensky ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Guided Surgery

258: Diagnosis and Intraoperative Staging of Bladder Disease by in-vivo Optical Coherence Tomography (OCT)

2004 ◽  
Vol 171 (4S) ◽  
pp. 68-68 ◽  
Author(s):  
Markus D. Sachs ◽  
Dmitry Daniltchenko ◽  
Eva Lankenau ◽  
Frank Koenig ◽  
Gerion Huettmann ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Bladder Disease
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