scholarly journals Sensitive Soul: The Unseen Role of Emotion in Extraordinary States by Michael A. Jawer

2021 ◽  
Vol 35 (2) ◽  
pp. 415-416
Author(s):  
Robert Bobrow
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Emotional Sensitivity ◽  
The Core ◽  
Wide Range ◽  
Post Traumatic ◽  
The Moment

Strong emotions underlie many telepathic events. Brain waves, the basis for electroencephalography, were discovered by Dr. Hans Berger after he suffered a serious accident and his sister, hundreds of miles away, who could not have known about this sent a telegram to ask if he was okay. Attempting to figure out how this could have happened, Dr. Berger ultimately recorded the first brain electrical activity, from his son. Similarly, a wife bolts upright from a deep sleep the moment her husband is killed in battle, on another continent. A murder victim’s life is later remembered by a child, unrelated and totally removed from the event. A lecturer suddenly experiences a pain in his knee so severe that he cannot continue his talk; simultaneously, it turns out, his twin brother has been hit in the leg by a car.             Emotions are instinctive and form the core of human nature. Michael A. Jawer, the author of Sensitive Soul, sees them as a “fundamental binding source” that connects humanity and makes the world turn. He applies this thesis to a wide range of medical and paranormal topics. Post-traumatic stress disorder is seen as an emotional sensitivity rather than a pathology. Migraines can be precipitated by emotions. Autism is seen as an engulfing and terrifying bombardment of the senses. Emotional stress may modify genes, via epigenetics, allowing transmission of fear across generations.

scholarly journals Genes and hormones of the hypothalamic–pituitary–adrenal axis in post-traumatic stress disorder. What is their role in symptom expression and treatment response?

2021 ◽  
Author(s):  
Susanne Fischer ◽  
Tabea Schumacher ◽  
Christine Knaevelsrud ◽  
Ulrike Ehlert ◽  
Sarah Schumacher
Keyword(s):  
Hpa Axis ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Ptsd Symptoms ◽  
Post Traumatic Stress ◽  
Alternative Treatments ◽  
Hypothalamic Pituitary Adrenal ◽  
Post Traumatic

Abstract Background Less than half of all individuals with post-traumatic stress disorder (PTSD) remit spontaneously and a large proportion of those seeking treatment do not respond sufficiently. This suggests that there may be subgroups of individuals who are in need of augmentative or alternative treatments. One of the most frequent pathophysiological findings in PTSD is alterations in the hypothalamic–pituitary–adrenal (HPA) axis, including enhanced negative feedback sensitivity and attenuated peripheral cortisol. Given the role of the HPA axis in cognition, this pattern may contribute to PTSD symptoms and interfere with key processes of standard first-line treatments, such as trauma-focused cognitive behavioural therapy (TF-CBT). Methods This review provides a comprehensive summary of the current state of research regarding the role of HPA axis functioning in PTSD symptoms and treatment. Results Overall, there is preliminary evidence that hypocortisolaemia contributes to symptom manifestation in PTSD; that it predicts non-responses to TF-CBT; and that it is subject to change in parallel with positive treatment trajectories. Moreover, there is evidence that genetic and epigenetic alterations within the genes NR3C1 and FKBP5 are associated with this hypocortisolaemic pattern and that some of these alterations change as symptoms improve over the course of treatment. Conclusions Future research priorities include investigations into the role of the HPA axis in day-to-day symptom variation, the time scale in which biological changes in response to treatment occur, and the effects of sex. Furthermore, before conceiving augmentative or alternative treatments that target the described mechanisms, multilevel studies are warranted.

scholarly journals The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Z. Ardi ◽  
A. Richter-Levin ◽  
L. Xu ◽  
X. Cao ◽  
H. Volkmer ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Ventral Hippocampus ◽  
Post Traumatic Stress ◽  
Adult Rats ◽  
Plus Maze ◽  
Post Traumatic ◽  
Exposure To Trauma

Abstract Pre-pubertal stress increases post-traumatic stress disorder (PTSD) susceptibility. We have previously demonstrated that enriched environment (EE) intervention immediately after pre-pubertal stress protects from the effects of trauma in adulthood. Here, we examined whether exposure to EE would also be beneficial if applied after exposure to trauma in adulthood. We have recently shown that exposure to juvenile stress and under-water trauma (UWT) is associated with increased expression of GABAA receptor subunit α1 in the ventral hippocampus. However, differentiating between affected and unaffected individuals, this increased expression was confined to stress-exposed, behaviorally unaffected individuals, suggesting upregulation of α1 expression as a potential mechanism of resilience. We now examined whether EE-induced resilience renders increased expression of α1 in the ventral hippocampus redundant when facing a trauma later in life. Adult rats were exposed to UWT, with pre-exposure to juvenile stress, and tested in the open field and elevated plus maze paradigms four weeks later. EE exposure during juvenility prevented pre-pubertal stress-induced vulnerability, but not if performed following UWT in adulthood. Furthermore, juvenile EE exposure prevented the trauma-associated increase in α1 expression levels. Our findings emphasize the importance of early interventions in order to reduce the likelihood of developing psychopathologies in adulthood.

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