scholarly journals Study on Correlation between Serum Prostate Specific Antigen and Various Prostatic Pathology

2018 ◽  
Vol 1 (2) ◽  
pp. 70-73
Author(s):  
Nirajan Mainali ◽  
Niraj Nepal ◽  
Prabesh Kumar Chaudhary ◽  
Jit Shrestha
Keyword(s):  
Histopathological Examination ◽  
Specific Antigen ◽  
Outlet Obstruction ◽  
Blood Stream ◽  
Study Patient ◽  
Antigen Level ◽  
Prostatic Specific Antigen ◽  
Medical College ◽  
Common Diagnosis ◽  
Organ Specific

Introduction: Prostatic enlargement that may due to any cause may give rise to bladder outlet obstruction. Prostatic specific antigen is the enzyme that is responsible for liquefaction of semen within a few minutes after it has clotted. Prostatic specific antigen is a widely used tumor marker for prostatic cancer. Prostatic specific antigen levels in the blood go up if the barrier between the lining epithelium and the blood stream is damaged. This study was done to determine the correlation between serum Prostatic specific antigen level and histological diagnosis in prostatic biopsy.Material and Methods: This is a one year prospective study carried out in the Department of Pathology, Nobel Medical College from August 16, 2016 to August 15 2017. A total of 175 cases were included in the study. Patient Prostatic specific antigen level were noted and biopsy specimen was collected after operation. Histopathological examination was done and correlation between HPE diagnosis and serum Prostatic specific antigen level was done.Results: Benign Prostatic Hyperplasia was the most common diagnosis that was encountered. Majority of the cases had a serum Prostatic specific antigen level less than 10 ng/ml. Serum Prostatic specific antigen level of more than 30 ng/ml was seen only in prostatic carcinoma.Conclusions: Serum Prostatic specific antigen is organ specific but not a disease for prostate. It can be used to monitor the carcinoma of the prostate rather than the diagnosis of the carcinoma.

scholarly journals MULTI NODULAR GOITER

2010 ◽  
Vol 17 (01) ◽  
pp. 40-43
Author(s):  
SYED ALI AKBAR ◽  
Mohammad Qasim ◽  
NAZIR AHMED ◽  
Zar Khan ◽  
JOHAR ALI ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Cervical Lymphadenopathy ◽  
Nodular Goiter ◽  
Follicular Carcinoma ◽  
Study Patient ◽  
Surgical Department ◽  
Medical College ◽  
Risk Of Malignancy ◽  
Azad Kashmir ◽  
A Prospective Study

Objective: I. To determine the frequency of malignancy in multi nodular goiter. II. To determine the histopathological types.Design: This is a prospective study. Setting: Surgical department of Foundation Hospital Rawalpindi and associated Teaching Hospital ofFrontier Medical College Abbottabad. Period: Aug. 2002 to Aug. 2007. Patients and Methods. One hundred patients with Multi nodular wereincluded in this study. Patient with diffuse goiter, solitary nodules, patient operated somewhere else and suspected cases of malignancy wereexcluded from the study. Tissue were sent to Armed Force Institute for histopathological examination. Patients were followed for 2 weeks aftersurgery with histopathological report, all the preoperative and postoperative findings were recorded in detail. Data was analyzed byusingSPSS 14. Results. Majority of patients studied, belonged to Azad Kashmir and Gilgit which are among the known endemic regions for goitrein Pakistan and other from Chakwal and Jhelum. Histopathology revealed 96 (96%) patients with multi nodular goiter, 3 (3%) papillary carcinomaand 1 (1 %) Follicular carcinoma. Conclusions: Multinodularity of the goitre should not be considered as low risk of malignancy and delay forsurgical intervention. Changes in the size of gland, the appearance of new and hard nodules or cervical lymphadenopathy may indicatemalignant change and prompt indication for surgery.

scholarly journals Relation of Age and Serum Prostatic-Specific Antigen level with Histopathological diagnosis in Transurethral Resection of Prostate specimen, an Experience from Eastern Tertiary Hospital

2019 ◽  
Vol 17 (2) ◽  
pp. 62-65
Author(s):  
Ram Sagar Shah ◽  
Dipesh Raj Pandey
Keyword(s):  
Transurethral Resection ◽  
Specific Antigen ◽  
Tertiary Hospital ◽  
Interquartile Range ◽  
Transurethral Resection Of Prostate ◽  
Histopathological Diagnosis ◽  
Prostatic Specific Antigen ◽  
Carcinoma Prostate ◽  
Common Diagnosis ◽  
Prostate Diseases

Background: Prostatic Specific Antigen (PSA) is a protease secreted by epithelial cells of prostate. Serum PSA level is increased when the normal structure of gland is destroyed by benign or malignant tumor or inflammation. Though there is established relation between PSA plasma level and age among the two most common prostate diseases (Benign prostatic hyperplasia and Carcinoma Prostate) in the literature, relation has not been explored in our part of the world, therefore, this study was done to see the relation between age and PSA amount with Prostate diseases. Material and Methods: This was a Cross-sectional study conducted in a tertiary hospital, Nobel Medical College Teaching Hospital from January 2017 to December 2018. Ethical clearance was obtained from Institutional Review Committee (IRC). All the cases of prostate diseases presenting to urology department undergoing transurethral resection of the prostate (TURP) were included. Histopathology report of TURP specimen were collected from department of pathology and the relationship between diagnosis, PSA level and age were established. Results: BPH was the most common diagnosis (72.41%). Age of BPH patients ranged from 48-78 years and mean age with SD was 60.56±7.32. Median age with interquartile range was 61.00. Similarly, in the BPH group, PSA value ranged between 0.80-15.40 ng/ml with mean PSA value along with SD being 5.64±4.16 ng/ml. Similarly, Median PSA value with interquartile range was 4.20ng/ml. Carcinoma Prostate (27.59%) was the second most common diagnosis. Histological type of all cases diagnosed as cancer was adenocarcinoma. Their age ranged between 54-83. Their mean age with SD was 67.67±7.68. Similarly, Median age with interquartile range was 68.00. PSA value in this group ranged between 8.50-147.30 ng/ml. Again, the mean PSA value with SD is 55.72±33.40 ng/ml. Similarly, Median PSA value with interquartile range is 54.30 ng/ml. Conclusion: PSA level in the blood of men over 40years is highly correlated with a Age, irrespective of diagnosis. In above 40 age group, with advancing age, Carcinoma Prostate becomes more and more common diagnosis than BPH. Similarly, average PSA level is higher in Carcinoma Prostate than BPH.

scholarly journals Pleural biopsy in the diagnosis of lymphocytic exudative pleural effusion

2016 ◽  
Vol 11 (4) ◽  
Author(s):  
Javed Asghar Magsi ◽  
Saulat Ullah Khan ◽  
Shamshad Rasul Awan
Keyword(s):  
Pleural Effusion ◽  
Histopathological Examination ◽  
Granulomatous Inflammation ◽  
Clinical Problem ◽  
Pleural Biopsy ◽  
Medical College ◽  
Fluid Analysis ◽  
Common Diagnosis ◽  
Common Causes ◽  
Exudative Pleural Effusion

Pleural effusion is a common clinical problem in developed as well as developing countries. Tuberculosis and malignancy are common causes of exudative pleural effusion with lymphocytic predominance`. It is very difficult to diagnose the underlying cause by clinical, radiological or even pleural fluid analysis. These cases usually require pleural biopsy for definitive diagnosis2. Pleural biopsy is a safe ad reliable procedure ad is recomended to perform in all cases of exudative pleural effusion. Objective of this study was to list the frequency of patients with lymphocytic exudative pleural effusion diagnosed on pleural biopsy. This study was conducted at the Institute of Chest Medicine Mayo Hospital Lahore. A total of 50 patients, who fulfilled the criteria, were included in this study and underwent closed pleural biopsy. These were then investigated by histopathology. Histopathological examination of pleural biopsy was performed by department of pathology King Edwerd Medical College Lahore. A total of 5 0 patients underwent; closed pleural biopsy. Adequate pleural tissue was obtained in 30 patients (60% of cases) the most common diagnosis made was granulomatous inflammation most likely tuberculosis. Histopathological evaluation of pleural biopsy specimens can lead to diagnosis in 46% of patients with exudative lymphocytic pleural effusion.

scholarly journals Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

2019 ◽  
Vol 9 (1) ◽  
pp. 1485-1489
Author(s):  
Sujata Pudasaini ◽  
Neeraj Subedi ◽  
Nagesh Mani Shrestha
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostate Specific Antigen ◽  
Histopathological Examination ◽  
Specific Antigen ◽  
Prostatic Hyperplasia ◽  
Prostate Specific Antigen Level ◽  
Antigen Level ◽  
Histopathological Findings ◽  
Prostatic Disease ◽  
Carcinoma Prostate

Background: Prostate specific antigen is a tumor marker though is expressed by both normal and neoplastic prostate tissue. The absolute value of Prostate specific antigen is useful for determining the extent of prostate cancer and its treatment. Prostate specific antigen also increases in cases like Benign Prostatic Hyperplasia and prostatitis. The availability of Prostate specific antigen as a marker has encouraged its use to diagnose both cancer and cancer recurrences. Materials and methods: This is a cross sectional study conducted in a tertiary hospital over a period of two years. Cases of prostatic disease undergoing surgery during the study period were taken. Prostate specific antigen level of all these cases were correlated with clinical and histopathological findings.  Results:  A total of 51 cases of prostatic disease underwent surgery during the study period with the mean age of 66.57 ± 10.68 years. On histopathological examination, 70.6% had benign prostatic hyperplasia and 17.6% had prostatic adenocarcinoma. Prostate specific antigen level was <4 ng/ml in 45.1% cases and >20.1ng/ml in 15.7%. In case of carcinoma prostate, 88.9% had prostate specific antigen level > 20.1ng/ml and 11.1% had prostate specific antigen level in a range of 10.1- 20 ng/ml. In case of chronic prostatitis, 66.7% had prostate specific antigen level in a range of 4.1-10 ng/ml. However, in case of high grade prostatic intraepithelial neoplasia (HGPIN), 66.7% had PSA level <4 ng/ml. Conclusions: Strong correlation of prostate specific antigen levels of > 20.1 ng/ml with carcinoma prostate was seen.

scholarly journals Evaluation of prostate specific antigen level in different age group of Patients in Eastern part of Nepal

2016 ◽  
Vol 5 (1) ◽  
pp. 14-19
Author(s):  
Rupesh Kumar Shreewastav ◽  
Chandra Prakash Gaire ◽  
Ashima Ghimire ◽  
Prashant Kumar Shah ◽  
Arambam Giridhari Singh
Keyword(s):  
Prostate Specific Antigen ◽  
Clinical Laboratory ◽  
Specific Antigen ◽  
College Teaching ◽  
Mean Value ◽  
Prostate Specific Antigen Level ◽  
Age Group ◽  
Antigen Level ◽  
Medical College ◽  
Normal Individuals

Background A study was conducted to evaluate Prostate specific antigen (PSA) level in different age group of patients in Nobel Medical College Teaching Hospital (NMCTH), Biratnagar, Eastern Nepal.Material and Methods A total of 1870 male patients (age 51-88), attending OPD in different departments of NMCTH, were sent to Clinical Laboratory Services for estimation of Prostate specific antigen from 1st January 2013 to 30thJune 2014 and recruited for this study after Institutional ethical approval. Blood serum of these patients was tested for Prostate specific antigen level by Chemiluminescence Immunoassay (CLIA). Mean value and standard deviation were calculated using Student’s two–tailed t–test. Analysis of data was performed using one– way ANOVA. Results are considered statistically significant if p ≤0.05.Results Out of 1870 patients, 178 patients showed significantly higher level of PSA in their serum when compared to normal individuals. Out of this 178, 37 were from age group of 51-60, 51 were from age group of 61-70, 42 were from age group of 71-80 and 48 were from age group of 81-88. The remaining 1692 patients were having PSA within normal limit. PSA was found to be elevated up to a maximum of 34.5 ng/ml in patient. PSA level of <4 ng/ml was considered normal for this study.Conclusion This study, thus determines the diagnostic level of PSA, in different age group of patients comparing with normal individuals in eastern Part of Nepal that can help in diagnosis, prognosis and management of prostate cancer.Journal of Nobel Medical College Volume 5, Number 1, Issue 8, January-July 2016, 14-19 

Sign in / Sign up

Export Citation Format

Share Document