scholarly journals Efficacy of single dose of 800μg of misoprostol in first trimester abortion

2012 ◽  
Vol 1 (2) ◽  
pp. 11-13
Author(s):  
Shanti Subedi

Objective: To assess the efficacy, safety and cost effectiveness of Misoprostol (Prostaglandin E1 analogue) as a single dose of 800?g in first trimester abortion Methods: A descriptive study was conducted in Nobel Medical College and Teaching Hospital from June 2010-June 2011 where 110 patients were enrolled for first trimester abortions including incomplete, missed, blighted ovum. Each woman received a single dose of 800?g of Misoprostol intravaginally and the the process of abortion was monitored to assess the outcome measures. Results: Successful abortion was seen in 102 patients (92.7%) with induction to delivery interval of < 24 hours and the remaining 8 (7.2%) of them had to undergo surgical evacuation. Side effects noted were lower abdominal pain, fever, nausea, vomiting, and diarrhoea. Mean hospital stay of the patients was 48 hours. Conclusion: Misoprostol is a safe, cost effective and efficacious drug for first trimester abortion even as a single dosage.DOI: http://dx.doi.org/10.3126/jonmc.v1i2.7293 Journal of Nobel Medical College (2012), Vol.1 No.2 p.11-13

2016 ◽  
Vol 10 (2) ◽  
Author(s):  
Javed Iqbal ◽  
Fouzia Nausheen ◽  
Arif Tajammal Khan ◽  
Shahida Sheikh

Aims and Objectives of Study: To compare the diagnostic accuracy of clinical and ultrasound evaluation in first trimester abortions and assess the impact of ultrasound on patient management. Study Design: Non-interventional comparative study conducted o n 100 patients, selected o n simple random basis from Gynae Outpatient Department. Study place: Department of Obstetrics & Gynaecology, Allama Iqbal Medical College and Jinnah Hospital, Lahore Materials and Methods: All the patients with symptoms of first trimester abortion were evaluated clinically and by ultrasound to formulate a diagnostic and management plan. Main Outcome Measures: Both Modalities were compared for diagnostic accuracy, positive and negative correlation in different types of abortions. Results: 34% of the patients were at l0 weeks of gestation, 28% were unsure of dates, 17% were at 11 weeks of gestation, 13% of the patients were at 9 weeks of gestation, 5% were at 6 weeks while 3% were at 7 weeks of gestation. Clinical diagnosis was made in 42% of cases; in 39% definite diagnosis was possible with combined clinical and ultrasound evaluation while in 19% no diagnosis was established with either modality In 89% of the cases the diagnosis was made on single ultrasound scan, while 11% required a repeat scan. Correlation between two modalities was present in 81% of the cases. Positive correlation was obtained in 59% and negative correlation was seen in 22% . The correlation was not possible in 19% of cases. Conclusion: Ultrasonography is an essential tool in diagnosis of early pregnancy failures especially where clinical evaluation is inconclusive.


2009 ◽  
Vol 16 (02) ◽  
pp. 285-288
Author(s):  
HAJI KHAN KHOHARO ◽  
IRSHAD ALI ALVI ◽  
ISRAR AHMED AKHUND ◽  
Fatima Qureshi,

(SUMMARY) Objective: The study was conducted to determine the HBV vaccination status in health care workers of Muhammad Medical College Mirpurkhas. Study design, Setting & Duration of Study: This was a descriptive study carried out at Muhammad Medical College Mirpurkhas, from December 2007 to February 2008. Subjects & Methods: Total 480 health care workers were included; both male and female. Vaccination status & other data were filled on preformed Questionnaire proforma, if vaccinated or not. And if vaccinated either complete or incomplete. Results: Total 480 health care workers were studied, including 300 (62.5%) male and 180 (37.5%) females. The mean age was 34±8.7 and 36 ± 9.3 years in vaccinated and non-vaccinated subjects respectively. A total of 255 (53.15%) were vaccinated, including 215 males and 40 females. A 225 (44.875%) patients were non-vaccinated including 85 males and 140 females. The prevaccination HBsAg status was checked and found negative in all the subjects. The frequency of vaccination was highest among house officer 55 (91.66%) and lowest in the sanitary workers 3 (11.5%). The most common reason of not being vaccinated was non-affordability (high cost of vaccine). C o n c l u s i o n s : We conclude that a substantial number of health care workers are not vaccinated. So it demands a need for a more aggressive approach to be vaccinated and vaccine must be cost effective.


Author(s):  
Munjal J. Pandya ◽  
Neha V. Ninama ◽  
Chirag V. Thummar ◽  
Meet K. Patel

Background: Ectopic pregnancy is an acute emergency in obstetric if not timely diagnosed and timely treated. Ectopic pregnancy is leading cause of death in first trimester. Ectopic pregnancy can be managed surgically or medically. Medical management with Methotrexate administration avoids anesthesia in surgery, is cost effective and also offers success rate comparable to surgical management. Aim and objectives were to study the role of methotrexate in ectopic pregnancyMethods: This will be a retrospective observational study conducted in Obstetrics and Gynecology department of AMC MET medical college. Study group constitutes of 30 females with ectopic pregnancy. Preliminary blood investigations, ultrasonography and beta-human chorionic gonadotropin (b-hcg) level will be tested. Patients will be treated with single dose of methotrexate 50 mg/M2. Follow up b-hcg level will be done after 48 hours. Response and tolerance to methotrexate will be monitored.Results: The success rate of methotrexate therapy in our study was 83.33% (n=25) and 16.66% (n=5) required surgical intervention with tubal ruptured and abdominal pain.Conclusions: Methotrexate treatment of ectopic pregnancies is safe and effective with no major side effects. It has the advantage of tubal conservation and saves patients from surgical intervention.


2016 ◽  
Vol 12 (2) ◽  
pp. 40-41
Author(s):  
Nazmussaba Ansari ◽  
CR Das ◽  
Miraj Alam Ansari

Introduction: Caesarean section is one of the most rewarding surgeries when performed in time and indication. The number of C/S has been growing rapidly in the developing as well as developed world.Aims & Objectives: Evaluation of prophylactic antibiotic in caesarean section.Methodology: This study was conducted in Nepalgunj Medical College Teaching Hospital, Kohalpur from June 2014 to September 2014. Group A consisted of 100 patient who were randomly allocated & injection ceftriaxone 1gm. I/V stat was given at the time of induction of anesthesia (30 mins. before incision). Group B also consisted of 100 patients who were given 5 days antibiotics.Results: In post operative evaluation the infection rate were compared in both groups, group A wound infection 2% and group B 3% , Endometritis - group A 1% and group B 2%, UTI- group A 3% and group B 4%, Fever - group A 6% and group B 4%.Conclusion: Single dose prophylactic antibiotic is comparable to multi dose antibiotic in this study. Since the single dose antibiotic is as efficacious as multi dose regime, it is advocated that single dose prophylactic antibiotic can be given in caesarean section as it is cost effective and as efficient as multi dose regimen.JNGMC Vol. 12 No. 2 December 2014, Page: 40-41


2013 ◽  
Vol 2 (16) ◽  
pp. 2669-2673
Author(s):  
Gopal Narasimaiah ◽  
Ravindra Pukale ◽  
Shilpa Shivanna B ◽  
Neha Sharma

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