scholarly journals Effect of ethanolic extract of Reissantia indica on the human breast cancer cell line (MCF-7)

2018 ◽  
Vol 7 (1) ◽  
pp. 10-12
Author(s):  
Gayathri P ◽  
◽  
Dhana Sekar V ◽  
Sudhakar K ◽  
Sangeetha M ◽  
...  

Reissantia indica belongs to the family Celastraceae, is a native shrub to Maharashtra and Bengal, India. Its distinct plant parts are said to possess different activities, natives of Maharashtra and Bengal are using the plant parts for various purposes. In this experiment, the effect of ethanolic extract to destroy the cancer cells was studied. Study was carried on with human breast cancer cell line (MCF-7). Preparation of cell line was done using the reagents under standard protocol. Effect of plant extract on the cancer cells were recorded at two different timings (24 & 48 Hrs) respectively. Various doses of plant extract and standard were taken and introduced into cell line. Using 96 well plates the cells were seeded and studied for the viability. From the tabulated records, it clearly shows us the dose dependent response for the inhibition of cells. The maximum concentration of the plant extract 100µg/ml was found to be effective

2002 ◽  
Vol 129 (1-2) ◽  
pp. 55-63 ◽  
Author(s):  
Christel M Olsen ◽  
Elise T.M Meussen-Elholm ◽  
Jørn A Holme ◽  
Jan K Hongslo

2021 ◽  
Vol 66 (1) ◽  
pp. 65-71
Author(s):  
Hung Nguyen Phi ◽  
Toan Tran Quoc ◽  
Tuan Nguyen Anh ◽  
Vy Trinh Ngoc Thao ◽  
Yen Ngo Thi Ngoc ◽  
...  

Three alkaloids (named rutaecarpine (1), evodiamine (2), schinifoline (3) and one phenylpropanoid, integrifoliodiol (4)) have been isolated from the EtOAc extract of the fruits of Tetradium ruticarpum (A. Juss.) T. G. Hartley collected in Lang Son province. Their structures have been identified by using 1D and 2D NMR spectroscopies. All four compounds were tested for their cytotoxicity against the human breast cancer cell line (MCF-7) and tamoxifen-resistant breast cancer cell line (MCF\TAMR). The results showed that rutaecarpine (1) inhibited the growth of MCF7 and MCF\TAMR with its IC50 values of 41.2 and 64.6 µM, respectively. In addition, compounds 1, 2, and 4 showed moderate activity toward MCF-7 cell line.


2003 ◽  
Vol 32 (8) ◽  
pp. 1595-1603 ◽  
Author(s):  
J. Vassy ◽  
S. Portet ◽  
M. Beil ◽  
G. Millot ◽  
F. Fauvel-Lafève ◽  
...  

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