scholarly journals Management of Diabetic Ketoacidosis in Patients with Diabetes Type I

2019 ◽  
Author(s):  
Basam Zuhaer Sindi ◽  
Naif Mishkhas Alazwari ◽  
Abdulaziz Mohammed Khateeb ◽  
Aqil Abdulmonem Alzaher ◽  
Mohammad Abdulaziz M Alkhawajah ◽  
...  
Keyword(s):  
Diabetic Ketoacidosis ◽  
Fluid Replacement ◽  
Diabetic Patients ◽  
Type I ◽  
Care Providers ◽  
Patients With Diabetes ◽  
Type One Diabetes ◽  
Diabetes Type I ◽  
Comprehensive Search ◽  
Health Complications

Background: DKA is the leading cause of mortality among pediatric age and young adults with T1D, responsible for almost 50% of all fatalities in diabetic patients younger than 24 years of age. Goals of DKA management include optimization of volume status, hyperglycemia and ketoacidosis, electrolyte abnormalities, and potential precipitating factors. Methodology: we conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1987, through February 2017. The following search terms were used: ketoacidosis, management of diabetic ketoacidosis, type I diabetic patients’ emergency complication, fluid replacement in DKA, insulin therapy approach. Aim: in this review, we aim at evaluating the various ways of approaching patients who suffer from type-one diabetes during ketoacidosis and keto-acidotic coma. We will try to understand the triggers and pathophysiology behind this condition, and explore ways to prevent them. Conclusion: prompt diagnoses, aggressive treatment, and education of patient and their care providers about prevention strategies must be implemented. Also, more studies are required in the area of preventing health complications due to these types of diseases to effectively manage DKA in the future.

scholarly journals Management of Diabetic Ketoacidosis in Patients with Diabetes Type I

2019 ◽  
Author(s):  
Basam Zuhaer Sindi ◽  
Naif Mishkhas Alazwari ◽  
Abdulaziz Mohammed Khateeb ◽  
Aqil Abdulmonem Alzaher ◽  
Mohammad Abdulaziz M Alkhawajah ◽  
...  
Keyword(s):  
Diabetic Ketoacidosis ◽  
Fluid Replacement ◽  
Diabetic Patients ◽  
Type I ◽  
Care Providers ◽  
Patients With Diabetes ◽  
Type One Diabetes ◽  
Diabetes Type I ◽  
Comprehensive Search ◽  
Health Complications

Background: DKA is the leading cause of mortality among pediatric age and young adults with T1D, responsible for almost 50% of all fatalities in diabetic patients younger than 24 years of age. Goals of DKA management include optimization of volume status, hyperglycemia and ketoacidosis, electrolyte abnormalities, and potential precipitating factors. Methodology: we conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1987, through February 2017. The following search terms were used: ketoacidosis, management of diabetic ketoacidosis, type I diabetic patients’ emergency complication, fluid replacement in DKA, insulin therapy approach. Aim: in this review, we aim at evaluating the various ways of approaching patients who suffer from type-one diabetes during ketoacidosis and keto-acidotic coma. We will try to understand the triggers and pathophysiology behind this condition, and explore ways to prevent them. Conclusion: prompt diagnoses, aggressive treatment, and education of patient and their care providers about prevention strategies must be implemented. Also, more studies are required in the area of preventing health complications due to these types of diseases to effectively manage DKA in the future.

scholarly journals Management of Diabetic Ketoacidosis in Patients with Diabetes Type I

2017 ◽  
Vol 69 (4) ◽  
pp. 2278-2285
Author(s):  
Basam Zuhaer Sindi ◽  
Naif Mishkhas Alazwari ◽  
Abdulaziz Mohammed Khateeb
Keyword(s):  
Diabetic Ketoacidosis ◽  
Diabetes Type ◽  
Type I ◽  
Patients With Diabetes ◽  
Diabetes Type I

scholarly journals Bilateral Diabetic Knee Neuroarthropathy in a Forty-Year-Old Patient

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Patrick Goetti ◽  
Nicolas Gallusser ◽  
Olivier Borens
Keyword(s):  
Joint Destruction ◽  
Young Patients ◽  
Joint Disease ◽  
Diabetic Patients ◽  
Type I ◽  
Bilateral Involvement ◽  
Satisfactory Outcome ◽  
History Of ◽  
Diabetes Type I ◽  
Low Incidence

Diabetic osteoarthropathy is a rare cause of neuropathic joint disease of the knee; bilateral involvement is even more exceptional. Diagnosis is often made late due to its unspecific symptoms and appropriate surgical management still needs to be defined, due to lack of evidence because of the disease’s low incidence. We report the case of a forty-year-old woman with history of diabetes type I who developed bilateral destructive Charcot knee arthropathy. Bilateral total knee arthroplasty was performed in order to achieve maximal functional outcome. Follow-up was marked by bilateral tibial periprosthetic fractures treated by osteosynthesis with a satisfactory outcome. The diagnosis of Charcot arthropathy should always be in mind when dealing with atraumatic joint destruction in diabetic patients. Arthroplasty should be considered as an alternative to arthrodesis in bilateral involvement in young patients.

scholarly journals Modulation of Insulin Gene Expression with CRISPR/Cas9-based Transcription Factors

2021 ◽  
Vol 9 (A) ◽  
pp. 876-881
Author(s):  
Bakhytzhan Alzhanuly ◽  
Zhussipbek Y. Mukhatayev ◽  
Dauren M. Botbayev ◽  
Yeldar Ashirbekov ◽  
Nurlybek D. Katkenov ◽  
...  
Keyword(s):  
Embryonic Stem ◽  
Cell Types ◽  
Diabetic Patients ◽  
Type I ◽  
Transcription Activator ◽  
New Approach ◽  
Donor Cells ◽  
Diabetes Type I ◽  
Promising Solution ◽  
Insulin Gene Expression

Background: The discovery and use of CRISPR/Cas9 technology have enabled researchers throughout the globe to continuously edit genomes for the benefit of science and medicine. Diabetes type I is one field of medicine where CRISPR/Cas9 has a strong potential for cell therapy development. The long-lasting paucity of healthy cells for clinical transplantation into diabetic patients has led to the search of new methods for producing β-cells from other human cell types. Embryonic stem cells are being studied worldwide as one most promising solution of this need. Aim: The aim of the study is to to check the feasibility of modulating human insulin transcription using CRISPR/Cas9-based synthetic transcription regulation factors. Results: A new approach for creating potential therapeutic donor cells with enhanced and suppressed insulin production based on one of the latest achievements of human genome editing was developed. Both synthetic transcription activator (VP64) and transcription repressor (KRAB) proteins were shown to function adequately well as a part of the whole CRISPR/Cas9-based system. We claim that our results have a lot to offer and can bring light to many studies where numerous labs are struggling on to treat this disease.

Adenosine deaminase activity and zinc levels in the serum of patients with diabetes mellitus

2016 ◽  
Vol 41 (6) ◽  
Author(s):  
Rana Turkal ◽  
Göksel Bahadır ◽  
Yasemin Erdoğan Döventaş ◽  
Goncagül Haklar ◽  
Önder Şirikçi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Adenosine Deaminase ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type I ◽  
Adenosine Deaminase Activity ◽  
Patients With Diabetes ◽  
Patient Groups ◽  
Zinc Levels ◽  
Two Parameters

AbstractObjective:Adenosine deaminase (ADA) specifically catalyzes the deamination of adenosine which has been proved to play an important role in modulation of insulin action on glucose metabolism. Zinc is an essential micronutrient that is directly involved in the physiology of insulin and may be an important agent to activate the ADA. We aimed to evaluate serum ADA activity, zinc levels and the relationship between these two parameters in diabetes mellitus.Methods:We investigated serum ADA activity and zinc levels in type I (n = 100) and type II diabetes mellitus patients (n = 151).Results:ADA activities of diabetic patients were significantly elevated, whereas zinc levels were significantly lower than those of healthy controls (p < 0.001). Compared with the well-controlled diabetic patient groups (HbAConclusion:Elevated ADA activity in diabetic patients with poor glycemic control may be a useful marker for therapy modulation.

Preoperative Assessment of the Patient with Diabetes Mellitus

2019 ◽  
Author(s):  
Sean A. Josephs ◽  
Gretchen A. Lemmink
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Ketoacidosis ◽  
Preoperative Assessment ◽  
Major Surgery ◽  
Key Words Diabetes Mellitus ◽  
Diabetic Patients ◽  
Key Words Diabetes ◽  
Hyperglycemic Hyperosmolar State ◽  
Patients With Diabetes

Diabetes mellitus is a major cause of morbidity and mortality.  Nearly 30 million Americans have diabetes, more than 25% of which are undiagnosed. Patients with diabetes have multiple problems that should be addressed prior to surgery. They often have uncontrolled glucose levels that should be treated preoperatively. Current studies suggest that outcomes may be improved if perioperative glycemic control is optimized. Patients with diabetes develop end-organ dysfunction that can complicate perioperative management. Preoperative assessment of cardiac, neurologic, vascular, and renal function is necessary for all patients with diabetes that undergo major surgery. Optimization of cardiac disease in particular can reduce major adverse cardiac events for patients with risk factors such as diabetes. Diabetic patients can occasionally present for major surgery with hyperglycemic emergencies such as diabetic ketoacidosis and hyperglycemic hyperosmolar state. These conditions require urgent treatment to prevent mortality regardless of the need for surgery. This article reviews the preoperative assessment and management of these issues. This review contains 1 figure, 4 tables, and 37 references. Key Words: diabetes mellitus (DM), end-organ damage, hyperglycemia, polyuria, polydipsia, polyphagia, perioperative glycemic management, diabetic ketoacidosis (DKA), hyperglycemic hyperosmolar state (HHS), perioperative cardiac risk factors

scholarly journals Impact of Diabetic Ketoacidosis on Thyroid Function in Patients with Diabetes Mellitus

2021 ◽  
Vol 2021 ◽  
pp. 1-26
Author(s):  
Yuling Xing ◽  
Jinhu Chen ◽  
Guangyao Song ◽  
Liying Zhao ◽  
Huijuan Ma
Keyword(s):  
Diabetic Ketoacidosis ◽  
Thyroid Function ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Cochrane Library ◽  
Diabetic Patients ◽  
Academic Journal ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
Diabetes Patients

Background. Changes in thyroid function in diabetes patients who developed diabetic ketoacidosis (DKA) still need to be fully elucidated. The aim of this study was to systematically review available data on the relationship between thyroid function and DKA in diabetes patients who developed DKA. Methods. Electronic databases (PubMed, EMBASE, Cochrane Library, and China Academic Journal Full-text Database (CNKI)) were searched systematically to search relevant literature before December 2020. The mean ± standard deviation and 95% confidence interval (95% CI) were used for evaluation, and sensitivity analysis was performed. Publication bias was estimated by funnel plot, Egger’s test, and Begger’s test. Results. 29 studies were included in the meta-analysis, and the indicators (T4, T3, FT3, FT4, TSH, T3RU, and rT3) of patients with DKA were compared and analyzed. The results of this study showed that the levels of T4, T3, FT3, FT4, and TSH were decreased and the level of rT3 was increased in patients with DKA. Compared with after treatment, the levels of T4, T3, FT3, and FT4 in patients with DKA were decreased before treatment, while the levels of rT3 were increased, and there was no significant difference in changes of TSH. With the aggravation of DKA, the levels of T4, T3, FT3, and FT4 will further decrease, while the changes of TSH have no statistical difference. Conclusion. Thyroid function changed in diabetic patients with DKA. It changed with the severity of DKA. This condition may be transient, preceding further recovery of DKA.

The effect of insulin withdrawal on intermediary metabolism in patients with diabetes secondary to chronic pancreatitis

1991 ◽  
Vol 124 (5) ◽  
pp. 510-515 ◽  
Author(s):  
Steen Larsen ◽  
Jannik Hilsted ◽  
Else K. Philipsen ◽  
Bente Tronier ◽  
Meta Damkjær Nielsen ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Cell Function ◽  
Blood Glucose Concentration ◽  
Insulin Dependent Diabetes ◽  
Diabetic Patients ◽  
Type I ◽  
Secondary Diabetes ◽  
Patients With Diabetes ◽  
Insulin Dependent ◽  
Beta Hydroxybutyrate

Abstract. Insulin was withdrawn from 7 patients with Type I (insulin-dependent) diabetes and 4 patients with insulin-dependent diabetes secondary to chronic pancreatitis, both groups without residual beta-cell function. Median plasma glucagon concentrations rose slightly, but significantly after withdrawal of insulin in Type I diabetic patients (from 14 (range: 11-16) to 19 (14-25) pmol/l by 6 h), but not in the patients with secondary diabetes. This was accompanied by a significantly higher increase in blood glucose concentration from 5.1 (4.9-5.7) to 15.2 (12.9-18.1) mmol/1 by 6 h in Type I diabetic patients compared with patients with secondary diabetes (from 4.9 (4.3-6.7) to 13.1 (10.9-13.5) mmol/l) (p<0.01). Beta-hydroxybutyrate increased to a similar extent in the two groups, whereas no significant increases were found in glycerol and lactate in any of the groups. Increased secretion of glucagon is not essential for the development of hyperglycemia and ketonemia in patients with diabetes secondary to chronic pancreatitis, but may augment the degree of hyperglycemia in Type I diabetic patients compared with patients having secondary diabetes.

scholarly journals RELATION OF ISLET CELLS ANTIBODIES AND RESIDUAL FUNCTION OF PANCREAS IN PATIENTS WITH DIABETES TYPE I

2014 ◽  
Vol 7 (1) ◽  
pp. 41
Author(s):  
T. A. Tihomirova ◽  
S. V. Lapin ◽  
N. F. Tolkacheva ◽  
Areg A. Totolian
Keyword(s):  
Islet Cells ◽  
Diabetes Type ◽  
Type I ◽  
Residual Function ◽  
Patients With Diabetes ◽  
Diabetes Type I

Health group education as a strategy to improve quality of life for diabetics

2010 ◽  
Vol 4 (3) ◽  
pp. 1426
Author(s):  
Susane Flores Cosentino ◽  
Lilian Zielke Hesler ◽  
Darleia König Küster ◽  
Ângela Cristina Duarte Lunkes ◽  
Maria da Graça Soler Rodrigues ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Health Education ◽  
Type I ◽  
Calidad De Vida ◽  
Health Group ◽  
Patients With Diabetes ◽  
Prevention And Health Promotion ◽  
Diabetes Type I

ABSTRACT Objective: to assess the profile of patients with diabetes type I and II belonging to the Friends Diabetic Association of Palmeira das Missões County/ RS, as well as through educational practices promoting health and improving the quality of life. Method: this is an participatory research with a qualitative approach performed with a group of diabetic people belonging to an association of diabetics. Results: it was possible to list the topics of greatest interest to the participants, highlighting issues related to food and the complications of diabetes. A planning of educational activities was held in the form of workshops, aimed at promoting health and improving the quality of life. Conclusion: it is noteworthy that the intervention groups in health education is key to disease prevention and health promotion, helping to improve the quality of life, being this action relevant to the knowledge and learning of future nurses. Descriptors: diabetes mellitus; health education; quality of life.RESUMO Objetivo: conhecer o perfil dos portadores de diabetes tipo I e II pertencentes à Associação Amigos Diabéticos do município de Palmeira das Missões/RS, assim como realizar práticas educativas promovendo a saúde e a melhoria da qualidade de vida. Método: trata-se de uma pesquisa participante, com abordagem qualitativa realizada com um grupo de pessoas diabéticas pertencentes a uma associação de diabéticos. Resultados: foi possível elencar os temas de maior interesse dos participantes, destacando-se questões relacionadas à alimentação e as complicações do diabetes. Realizou-se um planejamento de ações educativas em forma de oficinas, voltadas à promoção da saúde e melhoria da qualidade de vida. Conclusão: ressalta-se que a intervenção em grupos de educação em saúde é fundamental para prevenção de doenças e promoção da saúde, contribuindo para a melhoria da qualidade de vida, sendo esta ação relevante para o conhecimento e aprendizado de futuros enfermeiros. Descritores: diabetes mellitus; educação em saúde; qualidade de vida.RESUMENObjetivo: conocer al perfil de los portadores de la diabetes tipo I y II pertenecientes a la Asociación Amigos Diabéticos del municipio de Palmeira das Missões/RS, además de realizar practicas educativas promoviendo la salud y la mejora de la calidad de la vida. Método: es una investigación a los participantes, con abordaje cualitativo realizado con un grupo de personas diabéticas pertenecientes a una asociación de diabéticos. Resultados: fue posible seleccionar los temas de mayor interés de los participantes, destacándose cuestiones relacionadas a la alimentación y a las complicaciones de la diabetes. Se realizó un planeamiento de acciones educativas en forma de oficinas, destinadas a la promoción de la salud y mejora de la calidad de la vida. Conclusión: se resalta que la intervención en grupos de educación en salud es fundamental para la prevención de enfermedades y la promoción de la salud, contribuyendo para la mejora de la calidad de la vida, siendo esta acción relevante para el conocimiento y aprendizaje de futuros enfermeros. Descriptores: diabetes mellitus; educación en salud; calidad de vida. 

Sign in / Sign up

Export Citation Format

Share Document