scholarly journals 3D Printing Technology: The Impetus Concept in the Drug Delivery

2019 ◽  
Vol Volume-3 (Issue-4) ◽  
pp. 870-873
Author(s):  
Hardeep Singh Bambra ◽  
Mohd Mazhar ◽  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Printing Technology ◽  
3D Printing Technology

3D Printing Technology in Drug Delivery: Recent Progress and Application

2019 ◽  
Vol 24 (42) ◽  
pp. 5039-5048 ◽  
Author(s):  
Sabna Kotta ◽  
Anroop Nair ◽  
Nimer Alsabeelah
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Pharmaceutical Manufacturing ◽  
Layer By Layer ◽  
Printing Technology ◽  
Drug Dosing ◽  
3D Printing Technology ◽  
3D Printed

Background: 3D printing technology is a new chapter in pharmaceutical manufacturing and has gained vast interest in the recent past as it offers significant advantages over traditional pharmaceutical processes. Advances in technologies can lead to the design of suitable 3D printing device capable of producing formulations with intended drug release. Methods: This review summarizes the applications of 3D printing technology in various drug delivery systems. The applications are well arranged in different sections like uses in personalized drug dosing, complex drugrelease profiles, personalized topical treatment devices, novel dosage forms and drug delivery devices and 3D printed polypills. Results: This niche technology seems to be a transformative tool with more flexibility in pharmaceutical manufacturing. Typically, 3D printing is a layer-by-layer process having the ability to fabricate 3D formulations by depositing the product components by digital control. This additive manufacturing process can provide tailored and individualized dosing for treatment of patients different backgrounds with varied customs and metabolism pattern. In addition, this printing technology has the capacity for dispensing low volumes with accuracy along with accurate spatial control for customized drug delivery. After the FDA approval of first 3D printed tablet Spritam, the 3D printing technology is extensively explored in the arena of drug delivery. Conclusion: There is enormous scope for this promising technology in designing various delivery systems and provides customized patient-compatible formulations with polypills. The future of this technology will rely on its prospective to provide 3D printing systems capable of manufacturing personalized doses. In nutshell, the 3D approach is likely to revolutionize drug delivery systems to a new level, though need time to evolve.

Pharmaceutical Product Development Exploiting 3D Printing Technology: Conventional to Novel Drug Delivery System

2019 ◽  
Vol 24 (42) ◽  
pp. 5029-5038 ◽  
Author(s):  
Md. Shoaib Alam ◽  
Ayesha Akhtar ◽  
Iftikhar Ahsan ◽  
Sheikh Shafiq-un-Nabi
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Personalized Medicine ◽  
Drug Delivery System ◽  
Delivery System ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed ◽  
Novel Drug Delivery System ◽  
Novel Drug

Background: 3D printed pharmaceutical products are revolutionizing the pharmaceutical industry as a prospective mean to achieve a personalized method of treatments acquired to the specially designed need of each patient. It will depend upon age, weight, concomitants, pharmacogenetics and pharmacokinetic profile of the patient and thus transforming the current pharmaceutical market as a potential alternative to conventional medicine. 3D printing technology is getting more consideration in new medicine formulation development as a modern and better alternative to control many challenges associated with conventional medicinal products. There are many advantages of 3D printed medicines which create tremendous opportunities for improving the acceptance, accuracy and effectiveness of these medicines. In 2015, United State Food and Drug Administration has approved the first 3D printed tablet (Spritam®) and had shown the emerging importance of this technology. Methods: This review article summarizes as how in-depth knowledge of drugs and their manufacturing processes can assist to manage different strategies for various 3D printing methods. The principal goal of this review is to provide a brief introduction about the present techniques employed in tech -medicine evolution from conventional to a novel drug delivery system. Results: It is evidenced that through its unparalleled advantages of high-throughput, versatility, automation, precise spatial control and fabrication of hierarchical structures, the implementation of 3D printing for the expansion and delivery of controlled drugs acts as a pivotal role. Conclusion: 3D printing technology has an extraordinary ability to provide elasticity in the manufacturing and designing of composite products that can be utilized in programmable and personalized medicine. Personalized medicine helps in improving drug safety and minimizes side effects such as toxicity to individual human being which is associated with unsuitable drug dose.

Potential Advanced Drug Delivery Systems Based on Hydrogels in 3D Printing Technology for Cancer Treatment

2021 ◽  
pp. 323-348
Author(s):  
Agnieszka M. Jankowska ◽  
Magdalena B. Łabowska ◽  
Izabela Michalak ◽  
Patrycja Szymczyk-Ziółkowska ◽  
Julita Kulbacka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Printing Technology ◽  
3D Printing Technology

Two-photon polymerization microfabrication of hydrogels: an advanced 3D printing technology for tissue engineering and drug delivery

2015 ◽  
Vol 44 (15) ◽  
pp. 5031-5039 ◽  
Author(s):  
Jin-Feng Xing ◽  
Mei-Ling Zheng ◽  
Xuan-Ming Duan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
High Resolution ◽  
3D Printing ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Two Photon ◽  
Nano Scale ◽  
Two Photon Polymerization

Arbitrary and ultraprecise 3D hydrogels with high resolution on micro/nano scale can be produced by two-photon polymerization microfabrication as an advanced 3D printing technology.

3D Printing in Personalized Drug Delivery

2019 ◽  
Vol 24 (42) ◽  
pp. 5062-5071 ◽  
Author(s):  
Afsana ◽  
Vineet Jain ◽  
Nafis Haider ◽  
Keerti Jain
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Personalized Medicine ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Forms ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Fused Deposition ◽  
Personalized Medicines

Background: Personalized medicines are becoming more popular as they enable the use of patient’s genomics and hence help in better drug design with fewer side effects. In fact, several doses can be combined into one dosage form which suits the patient’s demography. 3 Dimensional (3D) printing technology for personalized medicine is a modern day treatment method based on genomics of patient. Methods: 3D printing technology uses digitally controlled devices for formulating API and excipients in a layer by layer pattern for developing a suitable personalized drug delivery system as per the need of patient. It includes various techniques like inkjet printing, fused deposition modelling which can further be classified into continuous inkjet system and drop on demand. In order to formulate such dosage forms, scientists have used various polymers to enhance their acceptance as well as therapeutic efficacy. Polymers like polyvinyl alcohol, poly (lactic acid) (PLA), poly (caprolactone) (PCL) etc can be used during manufacturing. Results: Varying number of dosage forms can be produced using 3D printing technology including immediate release tablets, pulsatile release tablets, and transdermal dosage forms etc. The 3D printing technology can be explored successfully to develop personalized medicines which could play a vital role in the treatment of lifethreatening diseases. Particularly, for patients taking multiple medicines, 3D printing method could be explored to design a single dosage in which various drugs can be incorporated. Further 3D printing based personalized drug delivery system could also be investigated in chemotherapy of cancer patients with the added advantage of the reduction in adverse effects. Conclusion: In this article, we have reviewed 3D printing technology and its uses in personalized medicine. Further, we also discussed the different techniques and materials used in drug delivery based on 3D printing along with various applications of the technology.

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