Utilization of Genomic Signatures for Personalized Treatment of Breast Cancer

2020 ◽  
pp. 117-132
Keyword(s):  
Breast Cancer ◽  
Personalized Treatment ◽  
Genomic Signatures

Utilization of Genomic Signatures for Personalized Treatment of Breast Cancer

2020 ◽  
pp. 107-122
Author(s):  
P. Kelly Marcom ◽  
Carey K. Anders ◽  
Geoffrey S. Ginsburg ◽  
Anil Potti ◽  
Joseph R. Nevins
Keyword(s):  
Breast Cancer ◽  
Personalized Treatment ◽  
Genomic Signatures

scholarly journals G-quadruplexes: a promising target for cancer therapy

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Nils Kosiol ◽  
Stefan Juranek ◽  
Peter Brossart ◽  
Annkristin Heine ◽  
Katrin Paeschke
Keyword(s):  
Breast Cancer ◽  
Structure Formation ◽  
Genome Instability ◽  
Treatment Options ◽  
Personalized Treatment ◽  
Cancer Development ◽  
Intratumor Heterogeneity ◽  
Dna And Rna ◽  
New Strategy ◽  
The Stability

AbstractDNA and RNA can fold into a variety of alternative conformations. In recent years, a particular nucleic acid structure was discussed to play a role in malignant transformation and cancer development. This structure is called a G-quadruplex (G4). G4 structure formation can drive genome instability by creating mutations, deletions and stimulating recombination events. The importance of G4 structures in the characterization of malignant cells was currently demonstrated in breast cancer samples. In this analysis a correlation between G4 structure formation and an increased intratumor heterogeneity was identified. This suggests that G4 structures might allow breast cancer stratification and supports the identification of new personalized treatment options. Because of the stability of G4 structures and their presence within most human oncogenic promoters and at telomeres, G4 structures are currently tested as a therapeutic target to downregulate transcription or to block telomere elongation in cancer cells. To date, different chemical molecules (G4 ligands) have been developed that aim to target G4 structures. In this review we discuss and compare G4 function and relevance for therapeutic approaches and their impact on cancer development for three cancer entities, which differ significantly in their amount and type of mutations: pancreatic cancer, leukemia and malignant melanoma. G4 structures might present a promising new strategy to individually target tumor cells and could support personalized treatment approaches in the future.

scholarly journals Identification of genomic signatures in circulating tumor cells from breast cancer

2015 ◽  
Vol 137 (2) ◽  
pp. 332-344 ◽  
Author(s):  
Nisha Kanwar ◽  
Pingzhao Hu ◽  
Philippe Bedard ◽  
Mark Clemons ◽  
David McCready ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Genomic Signatures

scholarly journals Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning

2015 ◽  
Vol 10 (1) ◽  
pp. 85-100 ◽  
Author(s):  
Stephanie N. Dorman ◽  
Katherina Baranova ◽  
Joan H.M. Knoll ◽  
Brad L. Urquhart ◽  
Gabriella Mariani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Machine Learning ◽  
Gemcitabine Resistance ◽  
Genomic Signatures

Abstract PD6-2: Identifying genomic signatures in circulating tumour cells from breast cancer

2013 ◽  
Author(s):  
N Kanwar ◽  
P Hu ◽  
P Bedard ◽  
M Clemons ◽  
D McCready ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Genomic Signatures

Abstract 811: Identifying genomic signatures within circulating breast cancer cells.

2013 ◽  
Author(s):  
Nisha Kanwar ◽  
Pingzhao Hu ◽  
Mark Clemons ◽  
Philippe Bedard ◽  
David McCready ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Genomic Signatures

scholarly journals Heterogeneity of Genomic Signatures in Breast Cancer Core Biopsy

2013 ◽  
Vol 24 ◽  
pp. iii25
Author(s):  
M. Jarzab ◽  
W. Bal ◽  
M. Kowalska ◽  
M. Kowal ◽  
J. Rembak-Szynkiewicz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Core Biopsy ◽  
Genomic Signatures
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