Carbonic anhydrase inhibitors: purification and inhibition studies of pigeon (Columba livia var. domestica) red blood cell carbonic anhydrase with sulfonamides

2011 ◽  
Vol 26 (5) ◽  
pp. 749-753 ◽  
Author(s):  
Özen Özensoy ◽  
Mikail Arslan ◽  
Claudiu T. Supuran
Keyword(s):  
Carbonic Anhydrase ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Columba Livia ◽  
Carbonic Anhydrase Inhibitors ◽  
Inhibition Studies

scholarly journals Changes in the red blood cell enzyme, carbonic anhydrase, following blood transfusion.

1981 ◽  
Vol 27 (6) ◽  
pp. 541-545
Author(s):  
Kenji Taki ◽  
Koji Murakami ◽  
Takae Kawamura ◽  
Mieko Takamura ◽  
Reiji Wakusawa
Keyword(s):  
Blood Transfusion ◽  
Carbonic Anhydrase ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Enzyme

Plasma volume conservation in pigeons: effects of air temperature during dehydration

1994 ◽  
Vol 267 (6) ◽  
pp. R1449-R1453 ◽  
Author(s):  
N. Carmi ◽  
B. Pinshow ◽  
M. Horowitz
Keyword(s):  
Blood Cell ◽  
Air Temperature ◽  
Plasma Volume ◽  
Red Blood Cell ◽  
Total Body Water ◽  
Ambient Air ◽  
Columba Livia ◽  
Ambient Conditions ◽  
Air Temperatures ◽  
Total Body

We assessed the effects of the ambient air temperature prevailing during dehydration, which included complete water and food deprivation, on plasma volume (PV) conservation in pigeons (Columba livia) exposed to air temperatures of 25 degrees C (n = 7), 36 degrees C (n = 12), and 40 degrees C (n = 24). The pigeons were dehydrated for 65.4, 32.3, and 27.7 h, on average, at 25, 36, and 40 degrees C, respectively. Dehydration rates averaged 5, 10, and 15.2% of initial total body water (TBW) per day at the three air temperatures, in ascending order. Birds exposed to 25 and 36 degrees C maintained PV despite the fact that they lost, on average, 14 and 17.3% of their TBW, respectively. In contrast, PV in pigeons exposed to 40 degrees C decreased by 8.9%, even though the reduction in TBW (17.7%) was similar to that incurred at 36 degrees C. Mean plasma osmolalities reached 347.7, 345.6, and 374.8 mosmol/kgH2O at 25, 36, and 40 degrees C, respectively. No significant changes occurred in hematocrit (Hct) and hemoglobin concentrations (Hb) during dehydration at 25 and 36 degrees C. However, at 40 degrees C Hb increased by 8.2% with no change in Hct, indicating a decrease in red blood cell volume (RBCV). The results of this study suggest that maintenance of PV and RBCV is affected not only by the dehydration level attained but also by the ambient conditions under which dehydration is induced and the rate at which dehydration takes place.

Carbonic Anhydrase Inhibitors. DNA Cloning, Characterization, and Inhibition Studies of the Human Secretory Isoform VI, a New Target for Sulfonamide and Sulfamate Inhibitors

2007 ◽  
Vol 50 (2) ◽  
pp. 381-388 ◽  
Author(s):  
Isao Nishimori ◽  
Tomoko Minakuchi ◽  
Saburo Onishi ◽  
Daniela Vullo ◽  
Andrea Scozzafava ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Inhibitors ◽  
Dna Cloning ◽  
Inhibition Studies

Methazolamide-Associated Temporary Leukopenia and Thrombocytopenia

DICP ◽  
1989 ◽  
Vol 23 (1) ◽  
pp. 58-59 ◽  
Author(s):  
Amos M. Cohen ◽  
Michael Prialnik ◽  
David S. Ben-Nissan ◽  
Hanna Savir
Keyword(s):  
Carbonic Anhydrase ◽  
Blood Cell ◽  
White Blood Cell ◽  
Blood Count ◽  
Open Angle Glaucoma ◽  
Complete Recovery ◽  
Open Angle ◽  
Carbonic Anhydrase Inhibitors ◽  
Platelet Counts ◽  
Chronic Open Angle Glaucoma

A three-week course of methazolamide therapy for chronic open-angle glaucoma resulted in marked leukopenia and thrombocytopenia. Prompt discontinuation of therapy resulted in complete recovery of white blood cell and platelet counts within five days. The recommendations for patients receiving carbonic anhydrase inhibitors for blood count control at six-month intervals are discussed.

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