Risk factors in elderly taking psychotropic drugs: Significance of genetic polymorphism in drug oxidation

1993 ◽  
Vol 47 (sup28) ◽  
pp. 85-89 ◽  
Author(s):  
Lars F. Gram ◽  
Kim Brøsen ◽  
Søren H. Sindrup ◽  
Erik Skjelbo
Keyword(s):  
Risk Factors ◽  
Genetic Polymorphism ◽  
Psychotropic Drugs ◽  
Drug Oxidation

Interleukin-6 G-174C gene polymorphism and serum resistin levels in North Indian women: Potential risk of metabolic syndrome

2010 ◽  
Vol 30 (10) ◽  
pp. 1445-1453 ◽  
Author(s):  
A Gupta ◽  
V Gupta ◽  
AK Singh ◽  
S Tiwari ◽  
S Agrawal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Genetic Polymorphism ◽  
Interleukin 6 ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Obese Women ◽  
Resistin Level ◽  
Indian Women ◽  
Mutant Genotype

The present investigations were aimed to identify the possible association between genetic polymorphism in interleukin-6 (IL-6) G-174C gene, which confers susceptibility to metabolic syndrome, and serum level of resistin in North Indian women. The study population comprised 370 unrelated Indian women (192 having abdominal obesity and 178 controls). Polymorphism in genotype (CC+GC) of IL-6 G-174C gene was determined using a combination of polymerase chain reaction (PCR) and sequence-specific primer with restriction fragment length polymorphism (RFLP) technology. Insulin resistance (IR) and serum resistin level were also analyzed along with metabolic risk factors. Of 192 abdominal obese women, 147 (76.56%) were found to have mutant CC+GC ( p = 0.001) genotype and allele frequency ( p = 0.001), which was significantly higher 45 (23.44%) than non-obese and their respective wild type. The mutant genotype (CC+GC) of IL-6 gene was found to be associated significantly with high triglyceride ( p = 0.025) and resistin level ( p < 0.001), when compared with respective wild genotype (GG) in obese women. Non-obese women with no signs of metabolic risk factors were found to have significantly low level of serum resistin and IR in comparison to obese women having genetic polymorphism for IL-6 G-174C gene. Study suggests that IL-6 G-174C gene is one among the susceptibility loci for metabolic syndrome in North Indian women. Genotype for this polymorphism may prove informative for prediction of genetic risk for metabolic syndrome. Further, high level of serum resistin molecules may be targeted to correlate with metabolic syndrome risk factors and could be used as early prediction marker.

Haemostatic Genetic Risk Factors in Arterial Thrombosis

2001 ◽  
Vol 86 (07) ◽  
pp. 374-385 ◽  
Author(s):  
Rachel Simmonds ◽  
José Hermida ◽  
Suely Rezende ◽  
David Lane
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Genetic Polymorphism ◽  
Genetic Risk ◽  
Arterial Thrombosis ◽  
Membrane Glycoprotein ◽  
Thrombotic Disease ◽  
Integral Role ◽  
Technical Simplicity ◽  
Digital Nature

SummaryHaemostasis plays an integral role in arterial thrombotic disease. However, establishing which of the factors are risk factors has proven surprisingly difficult. Because of its technical simplicity and digital nature, the study of haemostatic polymorphisms as risk factors has grown in popularity. Once established as a risk factor, a genetic polymorphism has the potential to aid selective prophylaxis and therapy of disease. Numerous reports have now been published on polymorphisms of coagulation and fibrinolytic factors, of coagulation and fibrinolytic inhibitory proteins, and of platelet membrane glycoprotein receptors. This article describes the polymorphisms and evaluates the results of these studies using the premises of consistency of within-report genotype/phenotype/disease relationships and consistency of outcome between studies. Many studies have been only of association between polymorphisms and disease, a type of study that is prone to error. Furthermore, the collective outcome of these studies has primarily been inconsistent. It is concluded that despite the early promise of polymorphisms as risk factors, fresh approaches differing in scale and design are now required to clarify their possible importance.

scholarly journals Cutaneous adverse drug reactions to psychotropic drugs and their risk factors – a case-control study

2019 ◽  
Vol 29 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Waldemar Greil ◽  
Xueqiong Zhang ◽  
Hans Stassen ◽  
Renate Grohmann ◽  
René Bridler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adverse Drug Reactions ◽  
Psychotropic Drugs ◽  
Case Control Study ◽  
Case Control ◽  
Drug Reactions ◽  
Control Study

NEUROLEPTIC-INDUCED ACUTE DYSTONIC REACTIONS: PREVALENCE, RISK FACTORS AND RELATIONSHIP TO DEFECTIVE DRUG OXIDATION

1992 ◽  
Vol 15 ◽  
pp. 269B
Author(s):  
E. Spina ◽  
V. Sturiale ◽  
M. Ancione ◽  
A. E. Di Rosa ◽  
M. Meduri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Drug Oxidation

scholarly journals Toxoplasmic retinochoroiditis: The influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0211627 ◽  
Author(s):  
Ana Luisa Quintella do Couto Aleixo ◽  
Raquel Vasconcelos C. de Oliveira ◽  
Maíra Cavalcanti Albuquerque ◽  
Ana Luiza Biancardi ◽  
André Luiz Land Curi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Survival Analysis ◽  
Genetic Polymorphism ◽  
Toxoplasmic Retinochoroiditis ◽  
Risk Factors For Recurrence ◽  
Ifn Γ

ABCB1 and ABCC2 genetic polymorphism as risk factors for neutropenia in esophageal cancer patients treated with docetaxel, cisplatin, and 5-fluorouracil chemotherapy

2020 ◽  
Vol 86 (2) ◽  
pp. 315-324 ◽  
Author(s):  
Hisanaga Nomura ◽  
Daiki Tsuji ◽  
Ken Demachi ◽  
Nobuo Mochizuki ◽  
Haruki Matsuzawa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Genetic Polymorphism ◽  
Cancer Patients

scholarly journals Risk factors for the development of pneumonia in acute psychotropic drugs poisoning

2005 ◽  
Vol 62 (10) ◽  
pp. 715-723
Author(s):  
Slavica Vucinic
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Central Venous Catheter ◽  
Psychotropic Drugs ◽  
Univariate Analysis ◽  
Venous Catheter ◽  
Central Venous ◽  
Drug Poisoning ◽  
H2 Blockers ◽  
Underlying Diseases

Background/Aim. Pneumonia is the most frequent complication in acute psychotropic drugs poisoning, which results in substantial morbidity and mortality, but which also increases the costs of treatment. Risk factors for pneumonia are numerous: age, sex, place of the appearance of pneumonia, severity of underlying disease, airway instrumentation (intubation, reintubation, etc). The incidence of pneumonia varies in poisoning caused by the various groups of drugs. The aim of this study was to determine the incidence and risk factors for pneumonia in the patients with acute psychotropic drugs poisoning. Methods. A group of 782 patients, out of which 614 (78.5%) with psychotropic and 168 (21.5%) nonpsychotropic drug poisoning were analyzed prospectively during a two-year period. The diagnosis of pneumonia was made according to: clinical presentation, new and persistent pulmonary infiltrates on chest radiography, positive nonspecific parameters of inflammation, and the microbiological confirmation of causative microorganisms. To analyze predisposing risk factors for pneumonia, the following variables were recorded: sex, age, underlying diseases, endotracheal intubation, coma, severity of poisoning with different drugs, histamine H2 blockers, corticosteroids, mechanical ventilation, central venous catheter. The univariate analysis for pneumonia risk factors in all patients, and for each group separately was done. The multivariate analysis was performed using the logistic regression technique. Results. Pneumonia was found in 94 (12.02%) of the patients, 86 of which (91.5%) in psychotropic and 8 (8.5%) in nonpsychotropic drug poisoning. In the psychotropic drug group, pneumonia was the most frequent in antidepressant (47%), and the rarest in benzodiazepine poisoning (3.8%). A statistically significant incidence of pneumonia was found in the patients with acute antidpressant poisoning (p < 0.001). Univariate analysis showed statistical significance for the following parameters: sex (p < 0.05), chronic alcohol intake (p < 0.05), underlying diseases (p < 0.01), central venous catheter (p < 0.05) vasopressors (p < 0.05), coma (p < 0.001), H2 blockers (p < 0.001) and corticosteroids (p < 0.001). The multivariate analysis retained endotracheal intubation and antidepressant drug poisoning as an independent risk factor for pneumonia. Conclusion. Using univariate and multivariate analysis, risk factors for developing pneumonia were disclosed. Some of these factors may be modified by simple medical procedures, thus the incidence and mortality rate of pneumonia in drug poisoning might be substantially reduced.

scholarly journals The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Danchen Wang ◽  
Yutong Zou ◽  
Songlin Yu ◽  
Songbai Lin ◽  
Honglei Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Big Data ◽  
Cardiovascular Risk ◽  
Genetic Polymorphism ◽  
Cardiovascular Risk Factors ◽  
Gene Mutation ◽  
Chinese Population ◽  
Epidemiological Studies ◽  
College Hospital ◽  
Significant Difference

Abstract Background The ALDH2 rs671 genetic polymorphism has been linked with cardiovascular diseases (CVDs), but comprehensive epidemiological studies are lacking. An observational, retrospective big data study was carried out to evaluate the associations between this polymorphism and clustering cardiovascular risk factors (CRFs) in a Chinese population. Methods A total of 13,101 individuals (8431 males and 4670 females) were enrolled. Genetic polymorphism was assessed using gene mutation detection kits, coupled with an automatic fluorescent analyzer. Other data were obtained from the records of the Department of Health Care at Peking Union Medical College Hospital. Results Comparing the concentrations of common biochemical analytes, including BMI, SBP, DBP, ALT, AST, γ-GT, TBil, Cr, Glu, TC, TG, and HDL-C among individuals with the GG, GA, and AA genotypes of ALDH2 rs671, we found significant differences in males (all p < 0.001), but not in females. For males, the frequencies of hypertension, diabetes, and obesity were significantly higher for GG than for GA or AA (all p < 0.05). However, there was no significant difference for dyslipidemia, and no significant associations were observed for all frequencies in females. The prevalence of individuals with 1–4 CRFs was significantly higher among GG males than those carrying GA or AA, and fewer GG males had non-CRFs (all p < 0.05). Conclusion Polymorphisms of ALDH2 rs671 are associated with clustering CRFs, especially hypertension and diabetes in males, but not in females. These associations are likely mediated by alcohol intake, which is also associated with this gene.

Sign in / Sign up

Export Citation Format

Share Document