3H-Naloxone Binding in Brain Regions of Normotensive Wistar, Spontaneously Hypertensive and Renal Hypertensive Rats

1994 ◽  
Vol 3 (3) ◽  
pp. 202-205
Author(s):  
Ewa Widy-Tyszkiewicz ◽  
Jacek Kotapski ◽  
Andrzej Czlonkowski
Keyword(s):  
Brain Regions ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Renal Hypertensive Rats

scholarly journals Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats

1979 ◽  
Vol 75 (2) ◽  
pp. 99-106 ◽  
Author(s):  
Masanori SATO ◽  
Sakae MURATA ◽  
Hiroshi NARITA ◽  
Midori TOMITA ◽  
Keiko YAMASHITA ◽  
...  
Keyword(s):  
Diltiazem Hydrochloride ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Renal Hypertensive Rats

Pain sensitivity, thermal capability, and brain monoamine turnover in hypertensive rats

1987 ◽  
Vol 253 (6) ◽  
pp. R910-R916 ◽  
Author(s):  
C. F. Tsai ◽  
M. T. Lin
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Pain Sensitivity ◽  
Brain Regions ◽  
Spontaneous Pain ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Ambient Temperatures ◽  
Monoamine Turnover ◽  
Morphine Administration ◽  
Brain Monoamine

This study compared the pain sensitivity, thermal capability, and brain monoamine turnover in normotensive and hypertensive rats. Either the spontaneously hypertensive rats, the experimentally (renal or deoxycorticosterone acetate) hypertensive rats, or their normotensive controls were tested for pain sensitivity by the hot-plate procedure, with the plate maintained at 55 degrees C. The spontaneously hypertensive rats, but not the experimentally hypertensive rats, showed an elevated level of spontaneous pain threshold compared with their appropriate controls. However, both the spontaneously and the experimentally hypertensive rats displayed a reduced sensitivity of analgesic responses to morphine administration. In addition the thermal responses to external stresses in these groups of animals were assessed. It was found that, over an ambient temperature range of 8-30 degrees C, either spontaneously or experimentally hypertensive rats maintained their rectal temperature within a normal limit displayed by their appropriate controls. However, the metabolic rate levels of both spontaneously and experimentally hypertensive rats were elevated at ambient temperatures less than 22 degrees C. Furthermore, compared with their appropriate controls, these hypertensive rats also showed a greater degree of hypothermic responses to chlorpromazine injection. Biochemical examination revealed that either the spontaneously or the experimentally hypertensive rats had a lower serotonin, but a higher catecholamine, turnover in both the hypothalamus and the brain stem compared with their appropriate normotensive controls. The data indicate that, in a hypertensive state, changes in the monoamine turnover of different brain regions may be correlated with the above-mentioned alterations in pain sensitivity and in thermal capability.

Excitatory and inhibitory amino acid changes in ischemic brain regions in spontaneously hypertensive rats

1991 ◽  
Vol 16 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Hiroaki Ooboshi ◽  
Hiroshi Yao ◽  
Takashi Matsumoto ◽  
Makoto Hirano ◽  
Hideyuki Uchimura ◽  
...  
Keyword(s):  
Amino Acid ◽  
Spontaneously Hypertensive Rats ◽  
Brain Regions ◽  
Hypertensive Rats ◽  
Ischemic Brain ◽  
Spontaneously Hypertensive
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